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Table 1 Ugandan stakeholders’ hopes and concerns for gene drive mosquitoes for malaria control

From: Ugandan stakeholder hopes and concerns about gene drive mosquitoes for malaria control: new directions for gene drive risk governance

Hope sub-themes Themes Concern sub-themes
Effective at reducing malaria
Another possible tool in the fight against malaria
Ability of gene drive mosquitoes to address malaria Lack of public and political support hinders development and deployment
Technological intervention is ineffective
Ecological impacts
Less environmental impact than chemical pesticides
Socio-economic impacts
Increase in productivity and cost-savings
Impacts of gene drive testing and deployment Ecological impacts
Decrease in non-target organisms and/or species diversity as the elimination of the mosquito species reverberates through ecosystem
Gene drive construct spreads to, and negatively impacts, non-target organisms through vertical or horizontal gene transfer
Human health impacts
Emergence of new diseases and/or increase in the prevalence of existing diseases
Negative impacts on human health
Socio-economic impacts
Negative impacts on the economy and society
Costs and benefits unfairly distributed
  Governance of gene drive mosquitoes Novelty and irreversibility
High risk of irreversibility, uncertainty and lack of experiences create governance challenge
Excitement and hype crowd out alternative approaches to malaria reduction
Inter-state relations
Political conflict between neighbouring African nations
Institutional uncertainty
Unclear regulatory pathway and lack of regulatory capacity
Lack of transparency and independence
Lack of clarity on liability and responsibility