Table 2 Polymorphisms of CDS mutation in CYP2D6 gene between different vivax malaria cases
SR group | NR group | ORc | 95%CI | P | SNP ID in Genbank | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Loci | Codon changea | Amino acid change | No (n = 88, %b1) | Loci | Codon changea | Amino acid change | No. (n = 150, %b2) | Upper limit | Low limit | ||||
c.31 | GTG > ATG | V11M | 1 (0.7) | – | – | – | – | – | – | – | – | rs769258 | |
c.100 | CCA > TCA | P34S | 47 (53.4) | c.100 | CCA > TCA | P34S | 95 (63.3) | 0.664 | 0.389 | 1.133 | 0.132d (NS) | rs1065852 | |
c.271 | CTG > ATG | L91M | 4 (4.5) | c.271 | CTG > TTG | L91L | 2 (1.3) | 3.524 | 0.632 | 19.647 | 0.272d (NS) | rs28371703 | |
c.281 | CAC > CGC | H94R | 4 (4.5) | – | – | – | – | – | – | – | – | rs28371704 | |
c.294 | ACC > ACG | T98T | 4 (4.5) | c.294 | ACC > ACG | T98T | 1 (0.7) | 7.095 | 0.780 | 64.521 | 0.122d (NS) | rs28371705 | |
c.297 | GCC > GCT | A99A | 1 (1.4) | – | – | – | – | – | – | – | – | rs200269944 | |
c.336 | TTC > TTT | F112F | 42 (47.7) | c.336 | TTC > TTT | F112F | 81 (54.0) | 0.778 | 0.459 | 1.318 | 0.350d (NS) | rs1081003 | |
c.408 | GTG > GTC | V136V | 75 (85.2) | c.408 | GTG > GTC | V136V | 114 (76.0) | 1.822 | 0.907 | 3.661 | 0.089d (NS) | rs1058164 | |
c.505 | GGT > AGT | G169S | 2 (2.3) | – | – | – | – | – | – | – | – | rs5030865 | |
– | – | – | – | c.801 | CCC > CCA | P267P | 2 (1.3) | – | – | – | – | rs28371718 | |
c.886 | CGC > TGC | R296C | 22 (23.9) | c.886 | CGC > TGC | R296C | 20 (13.3) | 2.167 | 1.104 | 4.252 | 0.023d (S) | rs16947 | |
c.1457 | AGC > ACC | S486T | 75 (85.2) | c.1457 | AGC > ACC | S486T | 108 (72.0) | 1.416 | 0.819 | 2.447 | 0.212d (NS) | rs1135840 | |