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Table 3 The association between CYP2D6 genotypes and the relapse of vivax malaria

From: The association of CYP2D6 gene polymorphisms in the full-length coding region with higher recurrence rate of vivax malaria in Yunnan Province, China

Alleles Total
No (n1 = 238, F/%)
Case groups x2 P
SR group
No. (n1 = 88, F/%)
NR group
No. (n1 = 150, F/%)
a. Alleles
*1 47 (19.7) 10 (11.4) 37 (24.7) 6.193 0.013b (S)
*2 17 (7.1) 14 (15.9) 3 (2.0) 16.177 0.000b (S)
*4 3 (1.3) 3 (3.4) 0 2.802 0.094b (NS)
*10 108 (45.4) 34 (38.6) 74 (49.3) 2.560 0.110b (NS)
*39 28 (11.8) 15 (17.0) 13 (8.7) 3.751 0.053b (NS)
*sa 20 (8.4) 5 (5.7) 15 (10.0) 1.344 0.246b (NS)
Othera 15 (6.3) 7 (8.0) 8 (5.3) 1.766 0.184b (NS)
Genotypes Case groups ORc 95%CI P
SR group
No. (n2 = 44, F/%)
NR group
No. (n2 = 75, F/%)
Upper limit Low limit
b. Genotypes
*1/*1 1 (2.3) 11 (14.7) 0.135 0.017 1.087 0.064b (NS)
*2/*2 4 (9.1) 1 (1.3) 7.400 0.800 68.463 0.118b (NS)
*1/*2 4 (9.1) 1 (1.3) 7.400 0.800 68.463 0.118b (NS)
*1/*10 2 (4.5) 12 (16.0) 0.250 0.050 1.174 0.115b (NS)
*10/*10 12 (27.3) 24 (32.0) 0.797 0.350 1.873 0.588b (NS)
*10/*sa 1 (2.3) 1 (1.3) 1.721 0.105 28.220 1.000b (NS)
*10/*39 5 (11.4) 3 (4.0) 3.077 0.698 13.563 0.242b (NS)
*39/*39 2 (4.5) 1 (1.3) 3.524 0.310 40.032 0.636b (NS)
*39/*sa 2 (4.5) 7 (9.3) 0.463 0.092 2.332 0.552b (NS)
  1. n1 number of chromosomes, n2 number of cases, F Frequency
  2. Other: *m, *n, *o, *p, *q,*r,*t, *u, *v, *w and *x; a They could not meet the allele inclusion criteria provided by the Allele Nomenclature Committee [32]; bChi-square test; NS: not significant (P > 0.05); cThe OR value of genotypes were calculated by comparing to the relapse rate of P. vivax; S: significant (P < 0.05); NS: not significant (P > 0.05)