Health facility-based malaria incidence | Calculated from confirmed malaria cases seeking care at public health facilities and community health workers in Mopeia, measured following an enhanced passive surveillance approach Used in the main analysis for both cohorts |
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Community-based malaria incidence | Calculated from an active cohort of children under five years of age at community level Used in the univariate sensitivity analysis for the children under five cohort |
Malaria prevalence | Calculated in individuals of all ages for both study arms from the 2018 cross-sectional survey at the peak of the transmission season (April – May) Used in the univariate sensitivity analysis for both cohorts |
Severe malaria case | Malaria case requiring hospital admission. Computed from the total number of malaria infected according to the malaria severity ratio obtained from the trial Used in the main analysis for both cohorts |
Uncomplicated malaria case | Malaria case not requiring hospital admission |
Malaria case fatality rate | Malaria-associated case fatality rate estimated by the Global Burden of Disease (GBD) for the most current estimate (2017). Different estimates were used for the children under five and all age cohort Used in the main analysis for both cohorts |
IRS with community-wide protective effect | IRS achieving high coverage (> 85%) so that the population target benefits from a “mass effect” on the vector population [33] Used in the univariate sensitivity analysis for both cohorts |