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Table 2 Definition of malaria-related epidemiological measures used in the model

From: Cost and cost-effectiveness of indoor residual spraying with pirimiphos-methyl in a high malaria transmission district of Mozambique with high access to standard insecticide-treated nets

Health facility-based malaria incidence Calculated from confirmed malaria cases seeking care at public health facilities and community health workers in Mopeia, measured following an enhanced passive surveillance approach
Used in the main analysis for both cohorts
Community-based malaria incidence Calculated from an active cohort of children under five years of age at community level
Used in the univariate sensitivity analysis for the children under five cohort
Malaria prevalence Calculated in individuals of all ages for both study arms from the 2018 cross-sectional survey at the peak of the transmission season (April – May)
Used in the univariate sensitivity analysis for both cohorts
Severe malaria case Malaria case requiring hospital admission. Computed from the total number of malaria infected according to the malaria severity ratio obtained from the trial
Used in the main analysis for both cohorts
Uncomplicated malaria case Malaria case not requiring hospital admission
Malaria case fatality rate Malaria-associated case fatality rate estimated by the Global Burden of Disease (GBD) for the most current estimate (2017). Different estimates were used for the children under five and all age cohort
Used in the main analysis for both cohorts
IRS with community-wide protective effect IRS achieving high coverage (> 85%) so that the population target benefits from a “mass effect” on the vector population [33]
Used in the univariate sensitivity analysis for both cohorts
  1. IRS indoor residual spraying