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Table 3 Univariate sensitivity analysis: changes in selected parameters to account for uncertainty

From: Cost and cost-effectiveness of indoor residual spraying with pirimiphos-methyl in a high malaria transmission district of Mozambique with high access to standard insecticide-treated nets

Parameter Lower value Upper value Reference
Parameters changed for the cohort of children under five years of age (U5)
 IRS-arm malaria incidence: children U5 30% reduction IRR = 0.82 Assumption, [22]
 Malaria mortality rate (children U5) 20% reduction 20% increase Assumption
Parameters changed for both cohorts (children U5 and individuals of all ages)
 Malaria prevalence (instead of incidence) ORall = 0.70 and ORchildrenU5 = 0.54 [22]
 IRS-arm malaria incidence: all ages 10% reduction 10% increase Assumption
 IRS cost per person protected US$7.06 50% increase [36], assumption
 Malaria mortality rate (all ages) 6.134/10,000 10% increase [24], assumption
% severe malaria over all malaria cases 20% reduction 0.0122 Assumption, [37]
 Discount rate 0% 5% Assumption
 Health system cost—uncomplicated case US$3.54 US$5.12 [26]
  1. Changes on the average health system costs associated with malaria are based on: (1) assuming no cost of screening fever (US$3.53) and higher commodity costs (US$5.12). Malaria prevalence rates from cross-sectional studies were used as alternative to health facility-based malaria incidence rates in the main analysis
  2. IRR malaria incidence risk ratio, IRS  indoor residual spraying, OR odd ratio (malaria prevalence rates calculated from both study arms)