Skip to main content

Table 3 Univariate sensitivity analysis: changes in selected parameters to account for uncertainty

From: Cost and cost-effectiveness of indoor residual spraying with pirimiphos-methyl in a high malaria transmission district of Mozambique with high access to standard insecticide-treated nets

Parameter

Lower value

Upper value

Reference

Parameters changed for the cohort of children under five years of age (U5)

 IRS-arm malaria incidence: children U5

30% reduction

IRR = 0.82

Assumption, [22]

 Malaria mortality rate (children U5)

20% reduction

20% increase

Assumption

Parameters changed for both cohorts (children U5 and individuals of all ages)

 Malaria prevalence (instead of incidence)

ORall = 0.70 and ORchildrenU5 = 0.54

[22]

 IRS-arm malaria incidence: all ages

10% reduction

10% increase

Assumption

 IRS cost per person protected

US$7.06

50% increase

[36], assumption

 Malaria mortality rate (all ages)

6.134/10,000

10% increase

[24], assumption

% severe malaria over all malaria cases

20% reduction

0.0122

Assumption, [37]

 Discount rate

0%

5%

Assumption

 Health system cost—uncomplicated case

US$3.54

US$5.12

[26]

  1. Changes on the average health system costs associated with malaria are based on: (1) assuming no cost of screening fever (US$3.53) and higher commodity costs (US$5.12). Malaria prevalence rates from cross-sectional studies were used as alternative to health facility-based malaria incidence rates in the main analysis
  2. IRR malaria incidence risk ratio, IRS  indoor residual spraying, OR odd ratio (malaria prevalence rates calculated from both study arms)