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Table 1 Prevalence and density of P. falciparum at baseline and endpoint

From: Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study

 

Baseline

Endpoint

p value

OR/GMR (95%CI)

Parasite prevalence

 By microscopy

22/811 (3%)a

34/740 (5%)b

0.056

1.73 (0.97–3.13)

 By PCR

49/811 (6%)

42/740 (6%)

0.829

0.94 (0.60–1.46)

 By either test

52/811 (6%)

50/740 (7%)

0.838

1.06 (0.69–1.61)

 Median parasitaemia/µL (IQR) (microscopy)

440 (80–1800)

860 (92–2690)

0.351

 

 Median 18S copies/µL (IQR) (qPCR) (n baseline = 33, endpoint = 29)

59.4 (7.8–1475.0)

713.5 (7.6–899.1)

0.095

 

Gametocyte prevalence

 By microscopy

11/811 (1.4%)

15/740 (2.0%)

0.328

1.50 (0.64–3.65)

 By pfs25

19/803 (2%)

23/729 (3%)

0.353

1.34 (0.69–2.63)

 By either test

19/803 (2%)

23/729 (3%)

0.353

1.34 (0.69–2.63)

Gametocyte density (per μL)

 By microscopy (median) (IQR)

80 (48–280)

460 (80–860)

0.085

 

 By pfs25 (geometric mean) (95%CI)

132.5 (30.2–580.5)

210.9 (56.8–782.7)

0.625

0.6 (0.1–4.2)

  1. OR odds ratio, GMR geometric mean ratio
  2. aThree and beight subjects were not confirmed by PCR during baseline and endpoint, respectively. This is presumably due to degraded DNA and possible LM false positive given 10 of 11 (90%) showed negative microscopy during cross check