TY - JOUR AU - Assefa, Dawit Getachew AU - Zeleke, Eden Dagnachew AU - Bekele, Delayehu AU - Tesfahunei, Hanna Amanuel AU - Getachew, Emnet AU - Joseph, Michele AU - Manyazewal, Tsegahun PY - 2021 DA - 2021/04/01 TI - Efficacy and safety of dihydroartemisinin–piperaquine versus artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ugandan children: a systematic review and meta-analysis of randomized control trials JO - Malaria Journal SP - 174 VL - 20 IS - 1 AB - The emergence of artemisinin resistance in Southeast Asia and Plasmodium falciparum kelch13 propeller gene mutations in sub-Saharan African pose the greatest threat to global efforts to control malaria. This is a critical concern in Uganda, where artemisinin-based combination therapy (ACT) is the first-line treatment for uncomplicated falciparum. The objective of this study was to compare the efficacy and safety of dihydroartemisinin–piperaquine (DHA–PQ) and artemether–lumefantrine (AL) for the treatment of uncomplicated falciparum malaria in Ugandan children. SN - 1475-2875 UR - https://doi.org/10.1186/s12936-021-03711-4 DO - 10.1186/s12936-021-03711-4 ID - Assefa2021 ER -