Quality of care for adult in-patients with malaria in a tertiary hospital in Uganda

Kiguba, Ronald; Karamagi, Charles; Bird, Sheila M.

doi:10.1186/s12936-021-03712-3

Malaria Journal

Table 4 Missed Day 1 dosing of artesunate injection among 57 hospitalized patients who received in-hospital intravenous artesunate, Uganda, 2014

From: Quality of care for adult in-patients with malaria in a tertiary hospital in Uganda

Length of stay, days	Preadmission anti-malarial use	Admission Malaria Diagnosis	Discharge Malaria Diagnosis	AL co-prescribed	Switched to AL	AS Doses Prescribed	AS Doses Received	Day 1	Day 2	Day 3	Day 4	Day 5	Day 6	Day 8
3	No	Yes	No	No	No	3	1		1 dose
3	No	Yes	Yes	Yes	No	2	3	1 dose	2 doses
4	No	Yes	Yes	No	No	6	2	1 dose	1 dose
5	No	Yes	Yes	Yes	No	3	3	1 dose	1 dose	1 dose
2	No	Yes	Yes	Yes	No	2	1	1 dose
4	Yes	Yes	Yes	Yes	No	10	3	1 dose		1 dose	1 dose
5	No	No	No	No	No	3	2		2 doses
2	No	Yes	Yes	Yes	Yes	3	2	2 doses
4	No	Yes	No	Yes	Yes	3	2	1 dose	1 dose
5	Yes	Yes	Yes	Yes	Yes	3	1	1 dose
4	No	Yes	Yes	Yes	No	3	2	1 dose	1 dose
5	No	Yes	Yes	No	No	3	4		1 dose	2 doses	1 dose
5	No	Yes	Yes	No	No	3	3	1 dose	1 dose	1 dose
5	No	Yes	No	No	No	3	3		1 dose	1 dose	1 dose
10	Yes	Yes	No	No	No	3	2	1 dose	1 dose
3	Yes	No	No	No	No	2	3	1 dose	2 doses
5	Yes	Yes	Yes	Yes	No	2	2	1 dose	1 dose
2	No	Yes	Yes	Yes	No	3	2	1 dose	1 dose
3	No	Yes	Yes	Yes	No	2	3	2 doses	1 dose
10	No	No	No	No	No	3	4		1 dose	1 dose	2 doses
3	No	Yes	Yes	Yes	No	3	2		2 doses
5	No	No	Yes	Yes	No	2	3		1 dose	1 dose	1 dose
2	No	Yes	Yes	Yes	No	4	1	1 dose
3	Yes	Yes	Yes	Yes	No	4	3	1 dose	1 dose	1 dose
3	No	Yes	Yes	Yes	No	3	3	1 dose	2 doses
3	Yes	Yes	Yes	No	No	3	3	1 dose	1 dose	1 dose
3	Yes	Yes	Yes	Yes	No	3	2	1 dose	1 dose
5	Yes	Yes	Yes	Yes	No	3	4	1 dose	1 dose	1 dose	1 dose
4	Yes	Yes	Yes	Yes	No	3	3	1 dose	1 dose	1 dose
3	Yes	Yes	Yes	Yes	No	3	3	1 dose	1 dose	1 dose
5	Yes	Yes	Yes	Yes	No	3	3	1 dose		1 dose	1 dose
7	Yes	Yes	Yes	Yes	Yes	3	3	1 dose				1 dose	1 dose
5	No	No	No	Yes	No	3	3		1 dose	1 dose	1 dose
3	Yes	Yes	Yes	Yes	No	3	2	1 dose	1 dose
4	No	Yes	Yes	No	No	3	2	1 dose	1 dose
2	No	Yes	Yes	Yes	No	3	1	1 dose
9	No	Yes	Yes	No	No	3	2	1 dose	1 dose
6	No	Yes	Yes	No	No	3	3				1 dose	2 doses
3	Yes	No	No	Yes	No	3	1	1 dose
4	No	Yes	Yes	Yes	No	3	3		1 dose	2 doses
3	Yes	Yes	No	Yes	No	3	3	1 dose	2 doses
4	No	Yes	Yes	No	No	3	3	1 dose	1 dose	1 dose
3	Yes	No	Yes	Yes	No	3	3	1 dose	2 doses
4	Yes	Yes	Yes	Yes	No	3	3		1 dose	2 doses
9	No	Yes	Yes	Yes	Yes	4	3			1 dose	1 dose	1 dose
4	Yes	Yes	No	Yes	Yes	2	3		2 doses	1 dose
4	No	Yes	Yes	Yes	No	6	2			1 dose	1 dose
3	No	Yes	Yes	Yes	Yes	1	1	1 dose
16	Yes	Yes	No	No	No	3	3	1 dose	2 doses
4	No	Yes	Yes	No	No	3	1	1 dose
6	No	Yes	No	No	No	3	4	1 dose	1 dose	2 doses
5	No	Yes	Yes	Yes	No	3	3		2 doses	1 dose
3	No	Yes	No	No	No	1	1	1 dose
3	No	Yes	Yes	Yes	No	3	1		1 dose
4	Yes	No	No	No	No	2	2	1 dose	1 dose
15	Yes	No	Yes	No	No	3	8	1 dose	2 doses		1 dose	2 doses		2 doses
1	No	Yes	Yes	Yes	No	2	2	1 dose	1 dose
Missed-dose day, n								16	10	8	1	1
Dose-day data unavailable, n1								0	5	27	44	52
Dose-day data available, N*								57	52	30	13	5
Proportion of in-patients with missed Day 1 data, n/N ~								28%

The variation from 1 to 2 AS doses per calendar day depends on the time of day that an in-patient initiates treatment. Injectable AS is given at 0, 12, 24 h then in-patient is switched to oral AL if he/she can tolerate it. Thus, an in-patient might receive 1 to 2 AS doses per calendar-day and very rarely 3 AS doses
*N = [(The 57 artesunate users) – (Number of in-patients who did not have artesunate dose-day data)] or (57-n1); ~ 95% confidence intervals for the estimate is 28% (17–42%)

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