Table 2 Frequency of k13 propeller variants observed in this study

Wild type

–

–

–

241 (1)

–

WT

K189T

c.566A > C

AAA > ACA

1 [0.004]

240 [0.99]

–

NS

C469Y

c.1407C > G

TGC > TGG

1 [0.004]

240 [0.99]

Candidate

NS

M476I

c.1428G > T

ATG > ATT

3 [0.01]

238 [ 0.98]

Validated

NS

F483I

c.1447T > A

TTT > ATT

9 [0.04]

232 [0.96]

–

NS

S485N

c.1454G > A

AGT > AAT

7 [0.03]

234 [0.97]

–

NS

F491F

c.1473F > F

TTC > TTT

52 [0.22]

189 [0.78]

–

S

L492L

c.1476A > G

TTA > TTG

2 [0.01]

239 [0.99]

–

S

F506V

c.1516 T > G

TTT > GTT

8 [0.03]

232 [0.96]

–

NS

T508N

c.1523C > A

ACT > AAT

12 [0.05]

229 [0.95]

–

NS

S577L

c.1730S > L

TCA > TTA

13 [0.05]

228 [0.95]

–

NS