Table 4 Association between clinical manifestation and allelic subfamilies
Clinical manifestation | Allele | Yes | No | p-value | OR | CI95% | ||
|---|---|---|---|---|---|---|---|---|
n | % | n | % | |||||
Shock | K1 | 2 | 66.7 | 32 | 36.8 | 0.66 | 3.29 | 0.31–34.97 |
MAD20 | 0 | 0 | 42 | 48.3 | 0.29 | 1.07 | 0.99–1.15 | |
RO33 | 0 | 0 | 1 | 1.1 | 1.00 | 1.03 | 1.00–1.08 | |
K1 + MAD20 | 0 | 0 | 5 | 5.7 | 1.00 | 1.04 | 1.00–1.08 | |
K1 + RO33 | 1 | 33.3 | 3 | 3.5 | 0.30 | 10.75 | 1.21–95.20 | |
MAD20 + RO33 | 0 | 0 | 4 | 4.6 | 1.00 | 1.04 | 1.00–1.08 | |
Convulsion | K1 | 2 | 100 | 32 | 36.4 | 0.27 | 0.94 | 0.87–1.02 |
MAD20 | 0 | 0 | 42 | 47.7 | 0.54 | 1.04 | 0.98–1.11 | |
RO33 | 0 | 0 | 1 | 1.1 | 1.00 | 1.02 | 0.99–1.06 | |
K1 + MAD20 | 0 | 0 | 5 | 5.7 | 1.00 | 1.02 | 0.99–1.06 | |
K1 + RO33 | 0 | 0 | 4 | 4.6 | 1.00 | 1.02 | 0.99–1.06 | |
MAD20 + RO33 | 0 | 0 | 4 | 4.6 | 1.00 | 1.02 | 0.99–1.06 | |
Conscious disturbance | K1 | 2 | 50 | 32 | 37.2 | 1.00 | 1.65 | 0.24–11.16 |
MAD20 | 0 | 0 | 42 | 48.8 | 0,16 | 1.09 | 1.00–1.19 | |
RO33 | 0 | 0 | 1 | 1.2 | 1,00 | 1.05 | 1.00–1.10 | |
K1 + MAD20 | 0 | 0 | 5 | 5.8 | 1.00 | 1.05 | 1.00–1.10 | |
K1 + RO33 | 1 | 25 | 3 | 3.5 | 0.42 | 7.17 | 0.94–54.51 | |
MAD20 + RO33 | 1 | 25 | 3 | 3.5 | 0.42 | 7.17 | 0.94–54.51 | |
Anaemia | K1 | 14 | 42.4 | 20 | 35.1 | 0.64 | 1.21 | 0.71–2.09 |
MAD20 | 17 | 51.5 | 25 | 43.9 | 0.63 | 1.21 | 0.71–2.09 | |
RO33 | 1 | 3 | 0 | 0 | 0.78 | 2.78 | 2.11–3.67 | |
K1 + MAD20 | 1 | 3.1 | 4 | 7 | 0.75 | 0.53 | 0.09–3.13 | |
K1 + RO33 | 0 | 0 | 4 | 7 | 0.31 | 1.62 | 1.37–1.92 | |
MAD20 + RO33 | 0 | 0 | 4 | 7 | 0.31 | 1.62 | 1.37–1.92 | |
Haemoglobinuria | K1 | 9 | 50 | 25 | 34.7 | 0.36 | 1.65 | 0.73–3.74 |
MAD20 | 6 | 33.3 | 36 | 50 | 0.32 | 0.57 | 0.24–1.39 | |
RO33 | 0 | 0 | 1 | 1.3 | 1.00 | 1.25 | 1.13–1.39 | |
K1 + MAD20 | 1 | 5.6 | 4 | 5.6 | 1.00 | 1.00 | 0.16–6.07 | |
K1 + RO33 | 2 | 11.1 | 2 | 2.8 | 0.37 | 2.69 | 0.92–7.87 | |
MAD20 + RO33 | 0 | 0 | 4 | 5.6 | 0.70 | 1.26 | 1.13–1.41 | |
Splenomegaly | K1 | 29 | 36.7 | 5 | 45.4 | 0.82 | 0.96 | 0.81–1.13 |
MAD20 | 38 | 48.1 | 4 | 36.4 | 0.68 | 1.06 | 0.91–1.23 | |
RO33 | 1 | 1.3 | 0 | 0 | 1.00 | 1.14 | 1.06–1.23 | |
K1 + MAD20 | 5 | 6.3 | 0 | 0 | 0.88 | 1.15 | 1.06–1.25 | |
K1 + RO33 | 3 | 3.8 | 1 | 9.1 | 0.99 | 0.85 | 0.48–1.50 | |
MAD20 + RO33 | 3 | 3.8 | 1 | 9.1 | 0.99 | 0.85 | 0.48–1.50 | |
MAD20 | 26 | 45.6 | 16 | 48.5 | 0.90 | 1.06 | 0.76–1.49 | |
RO33 | 1 | 1.8 | 0 | 0 | 1.00 | 1.68 | 1.41–1.99 | |
K1 + MAD20 | 1 | 7 | 1 | 3 | 0.16 | 0.32 | 0.06–1.87 | |
K1 + RO33 | 4 | 7 | 0 | 0 | 0.25 | 1.72 | 1.44–2.06 | |
MAD20 + RO33 | 2 | 3.5 | 2 | 6.1 | 1.00 | 0.83 | 0.31–2.24 | |
Dyspnea | K1 | 26 | 38.3 | 8 | 36.4 | 1.00 | 1.00 | 0.79–1.26 |
MAD20 | 33 | 48.5 | 9 | 40.9 | 0.88 | 1.05 | 0.83–1.31 | |
RO33 | 1 | 1.5 | 0 | 0 | 1.00 | 1.31 | 1.17–1.47 | |
K1 + MAD20 | 2 | 2.9 | 3 | 13.7 | 0.15 | 0.51 | 0.17–1.49 | |
K1 + RO33 | 3 | 4.4 | 1 | 4.5 | 0.86 | 0.81 | 0.05–47.66 | |
MAD20 + RO33 | 3 | 4.4 | 1 | 4.5 | 0.86 | 0.81 | 0.05–47.66 | |
Abnormality in the value of kidney function | K1 | 32 | 37.2 | 2 | 50 | – | – | – |
MAD20 | 40 | 46.5 | 2 | 50 | – | – | – | |
RO33 | 1 | 1.3 | 0 | 0 | – | – | – | |
K1 + MAD20 | 5 | 5.8 | 0 | 0 | – | – | – | |
K1 + RO33 | 4 | 4.6 | 0 | 0 | – | – | – | |
MAD20 + RO33 | 4 | 4.6 | 0 | 0 | – | – | – | |
Fever (≥ 39.0 °C) | K1 | 23 | 44.2 | 11 | 28.9 | 0.22 | 1.84 | 0.6–5.66 |
MAD20 | 17 | 32.7 | 25 | 65.8 | – | – | – | |
RO33 | 1 | 1.9 | 0 | 0 | 0.22 | 1.84 | 0.6–5.66 | |
K1 + MAD20 | 3 | 5.8 | 2 | 5.3 | – | – | – | |
K1 + RO33 | 4 | 7.7 | 0 | 0 | – | – | – | |
MAD20 + RO33 | 4 | 7.7 | 0 | 0 | 0.77 | 1.32 | 0.13–17.73 | |