Skip to main content

Table 4 Association between clinical manifestation and allelic subfamilies

From: Allelic diversity of merozoite surface protein genes (msp1 and msp2) and clinical manifestations of Plasmodium falciparum malaria cases in Aceh, Indonesia

Clinical manifestation

Allele

Yes

No

p-value

OR

CI95%

n

%

n

%

Shock

K1

2

66.7

32

36.8

0.66

3.29

0.31–34.97

MAD20

0

0

42

48.3

0.29

1.07

0.99–1.15

RO33

0

0

1

1.1

1.00

1.03

1.00–1.08

K1 + MAD20

0

0

5

5.7

1.00

1.04

1.00–1.08

K1 + RO33

1

33.3

3

3.5

0.30

10.75

1.21–95.20

MAD20 + RO33

0

0

4

4.6

1.00

1.04

1.00–1.08

Convulsion

K1

2

100

32

36.4

0.27

0.94

0.87–1.02

MAD20

0

0

42

47.7

0.54

1.04

0.98–1.11

RO33

0

0

1

1.1

1.00

1.02

0.99–1.06

K1 + MAD20

0

0

5

5.7

1.00

1.02

0.99–1.06

K1 + RO33

0

0

4

4.6

1.00

1.02

0.99–1.06

MAD20 + RO33

0

0

4

4.6

1.00

1.02

0.99–1.06

Conscious disturbance

K1

2

50

32

37.2

1.00

1.65

0.24–11.16

MAD20

0

0

42

48.8

0,16

1.09

1.00–1.19

RO33

0

0

1

1.2

1,00

1.05

1.00–1.10

K1 + MAD20

0

0

5

5.8

1.00

1.05

1.00–1.10

K1 + RO33

1

25

3

3.5

0.42

7.17

0.94–54.51

MAD20 + RO33

1

25

3

3.5

0.42

7.17

0.94–54.51

Anaemia

K1

14

42.4

20

35.1

0.64

1.21

0.71–2.09

MAD20

17

51.5

25

43.9

0.63

1.21

0.71–2.09

RO33

1

3

0

0

0.78

2.78

2.11–3.67

K1 + MAD20

1

3.1

4

7

0.75

0.53

0.09–3.13

K1 + RO33

0

0

4

7

0.31

1.62

1.37–1.92

MAD20 + RO33

0

0

4

7

0.31

1.62

1.37–1.92

Haemoglobinuria

K1

9

50

25

34.7

0.36

1.65

0.73–3.74

MAD20

6

33.3

36

50

0.32

0.57

0.24–1.39

RO33

0

0

1

1.3

1.00

1.25

1.13–1.39

K1 + MAD20

1

5.6

4

5.6

1.00

1.00

0.16–6.07

K1 + RO33

2

11.1

2

2.8

0.37

2.69

0.92–7.87

MAD20 + RO33

0

0

4

5.6

0.70

1.26

1.13–1.41

Splenomegaly

K1

29

36.7

5

45.4

0.82

0.96

0.81–1.13

MAD20

38

48.1

4

36.4

0.68

1.06

0.91–1.23

RO33

1

1.3

0

0

1.00

1.14

1.06–1.23

K1 + MAD20

5

6.3

0

0

0.88

1.15

1.06–1.25

K1 + RO33

3

3.8

1

9.1

0.99

0.85

0.48–1.50

MAD20 + RO33

3

3.8

1

9.1

0.99

0.85

0.48–1.50

MAD20

26

45.6

16

48.5

0.90

1.06

0.76–1.49

RO33

1

1.8

0

0

1.00

1.68

1.41–1.99

K1 + MAD20

1

7

1

3

0.16

0.32

0.06–1.87

K1 + RO33

4

7

0

0

0.25

1.72

1.44–2.06

MAD20 + RO33

2

3.5

2

6.1

1.00

0.83

0.31–2.24

Dyspnea

K1

26

38.3

8

36.4

1.00

1.00

0.79–1.26

MAD20

33

48.5

9

40.9

0.88

1.05

0.83–1.31

RO33

1

1.5

0

0

1.00

1.31

1.17–1.47

K1 + MAD20

2

2.9

3

13.7

0.15

0.51

0.17–1.49

K1 + RO33

3

4.4

1

4.5

0.86

0.81

0.05–47.66

MAD20 + RO33

3

4.4

1

4.5

0.86

0.81

0.05–47.66

Abnormality in the value of kidney function

K1

32

37.2

2

50

MAD20

40

46.5

2

50

RO33

1

1.3

0

0

K1 + MAD20

5

5.8

0

0

K1 + RO33

4

4.6

0

0

MAD20 + RO33

4

4.6

0

0

Fever (≥ 39.0 °C)

K1

23

44.2

11

28.9

0.22

1.84

0.6–5.66

MAD20

17

32.7

25

65.8

RO33

1

1.9

0

0

0.22

1.84

0.6–5.66

K1 + MAD20

3

5.8

2

5.3

K1 + RO33

4

7.7

0

0

MAD20 + RO33

4

7.7

0

0

0.77

1.32

0.13–17.73