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Table 6 Unadjusted predictors tested for early and late treatment failures

From: Predictors of treatment failures of plasmodium falciparum malaria in Vietnam: a 4-year single‐centre retrospective study

Predictors

Early treatment failure*

Late treatment failure*

Yes

(n = 19)

No

(n = 246)

P value

OR (95% CI)

Yes

(n = 51)

No

(n = 214)

P value

OR (95% CI)

Male

84.2 (16)

83.3 (205)

0.5a

 

90.2 (46)

81.8 (175)

0.1c

 

Living in or travelling to malaria endemic areas 14 days prior to the onset of disease

  

0.112b

   

0.4b

 

 Living in endemic area

36.8 (7)

45.5 (112)

  

41.2 (21)

45.8 (98)

  

 Travel to endemic area

26.3 (5)

37.4 (92)

  

35.3 (18)

36.9 (79)

  

 Not living and not traveling to endemic area

36.8 (7)

17.1 (42)

  

23.5 (12)

17.3 (37)

  

Acquiring malaria before 2017

63.2 (12)

43.1 (106)

0.09c

 

47.1 (24)

43.9 (94)

0.7c

 

Number of days of illness at the time of admission > 7 days

10.5 (2)

26.5 (65)

0.17a

 

29.4 (15)

24.3 (52)

0.5c

 

Hyperparasitaemia

0

0.4 (1)

1a

 

0

0.5 (1)

1a

 

Severe malaria

63.2 (12)

18.7 (46)

< 0.001a

7.5 (2.8–20.0)

15.7 (8)

29.9 (50)

0.044c

0.44 (0.19–0.99)

Age (years)

41.7 ± 12.5

34.8 ± 13.0

0.027d

 

32.1 ± 12.3

36.1 ± 13.2

0.054d

 

Patients with parasitaemia 72 h of treatment

    

25 (12)

13.5 (28)

0.047c

2.14 (0.99–4.61)

Patients with fever 3 days of treatment

    

14.6 (6)

15.8 (29)

0.9c

 
  1. * %(N) for categorical variables and Mean ± SD for continuous variables
  2. a Fisher’s Exact test
  3. b Chi-square for trend test
  4. c Chi-square test
  5. d Student’s t test