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Table 2 Summary characteristics of included studies on the efficacy and safety of artemether-lumefantrine for treatment of uncomplicated P. falciparum malaria in Ethiopia from 2004–2020 (N = 1523)

From: Efficacy and safety of artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Ethiopia: a systematic review and meta-analysis

Study [Ref. No]

Study Settings

Study design

Study duration (months)

Inclusion for age

Transmission level

Patient Enrolled (N)a

Patient available (n)b

Mean Hg

Pf-GMPD

Length of follow up (DAYS)

Super-vision

Abamecha et al. [35]

Ilu-Harar Health Centre, Chewakadistrct, Ethiopia

One arm, prospective study

September-December 2017

Above 6 months of age

Moderate

80

76

11.7

12,374.3

28

Partial

Teklemariam et al. [44]

SetitHumera, Northwest Ethiopia

Single-arm prospective study

October 28, 2014 and January 9, 2015

≥ 6 months of age

High

92

79

13.2

27,798.0

28

Partial

Deressa et al. [42]

Kola Diba Health Centre (KHC) in the Dembia district, Northwest Ethiopia

Prospective cohort study

April 2015 to February 2016

Above 6 months of age

High

80

75

n/a

8377.8

28

Partial

Nega et al. [39]

Metehara Health Centre, Eastern Ethiopia

Open-label single-arm study

October 2014 to January 2015

≥ 6 months of age

Low-moderate

91

85

12.4

11,509.6

28

Partial

Wudneh et al. [49]

Gendewuha (Metema) Health Centre, Northwest Ethiopia

One-arm open-label study

October 2014 to January 2015

Above 6 months of age

Moderate

91

81

13.7

13,441.6

28

Partial

Kancheet al. [48]

Baddessa Health Centre, Wolaita Zone, Southern Ethiopia Wolaita Zone, Southern Ethiopia

One-arm prospective study

February–March 2015

> 5 years old

Moderate

86

88

10.8

4238.8

28

Partial

Mekonnenet al. [38]

Omo Nada health centre in southwestern Ethiopia

Prospective cohort study

August–December 2011

Above 6 months of age

Moderate

88

86

11.6

8404.0

28

Partial

Ebstie et al. 2015 [47]

Bahir Dar district, Northwest Ethiopia

Prospective observational cohort study

March and July 2012

> 5 years old

Moderate

93

89

10.8

8675.3

28

Partial

Getnet et al. [40]

Enfranze Health Centre, Northwest Ethiopia

One-arm, prospective study

January and May 2013

Above 6 months of age

Moderate

134

130

12.3

7898.0

28

Partial

Mulu et al. [45]

Kemisie Health Centre, Northeast Ethiopia

One-arm prospective study

September, 2012 to May, 2013

Above 6 months of age

Moderate

80

80

NR

10,454.0

28

NR

Eshetu et al. [36]

Agaro Health Centre, Jimma Health Centre, Serbo Health Centre, and Asendabo Health Centre

Open-label, single arm study

November 2008 and January 2009 and between August and December 2009

> 1 year

Moderate

348

315

NR

9720.0

28/42

non-supervised

Kinfu et al. [43]

Tumuga health centre Alamata district, Tigrai regional state, North Ethiopia

Prospective cohort study

August–November 2009

Above 6 months of age

Moderate

66

60

N/R

20,672.0

28

Partial

Hwang et al. [37]

Bishoftu Malaria Clinic and Bulbula Health Centre, Oromia Regional State, Ethiopia

Open-label, single arm study

October and November 2009

Above 6 months of age

Moderate

73

71

12.6

16,374.0

28/42

Partial

Assefa et al. [41]

Serbo Health Centre, Kersa District, Southwest, Ethiopia

Prospective cohort study

November 2007 and January 2008

N/R

Moderate

119

112

12.2

22,660.0

28

Partial

Kefyalew et al. [46]

AlabaKulito Health Centre, Southern Ethiopia

Prospective cohort study

October–December 2007

> 1 year

Low -moderate

102

102

11.4

8264.3

28

Partial

  1. N/R, Not reported; TES, therapeutic efficacy study; Hg, Haemoglobin; Pf-GMPD, Plasmodium falciparum geometric mean parasite density of asexual parasites per microlitre of blood
  2. aP. falciparum patients enrolled in study as per manuscript
  3. bPatients available for analysis from study