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Fig. 7 | Malaria Journal

Fig. 7

From: A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria

Fig. 7

Estimated Day 7 concentrations of artefenomel (a) and ferroquine (b) by treatment arm and region/age group. All doses of artefenomel and ferroquine are expressed as adult-equivalent doses. The boxplots show the sample medians, with the first and third quartiles. The whiskers represent the lowest/largest values no further than 1.5 times the interquartile range. Circles and triangles are individual patient values. Blue lines represent the median Cday7 in the exposure–response dataset: artefenomel 5.3 ng/mL and ferroquine 55 ng/mL. The PK Sets included all patients who received each study drug and had at least one evaluable blood sample for PK (n = 364 for artefenomel; n = 367 for ferroquine)

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