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Table 5 Sensitivity and specificity for P. vivax and P. falciparum detection

From: Multicopy targets for Plasmodium vivax and Plasmodium falciparum detection by colorimetric LAMP

  Mini Spin Column Boil & Spin
PvCOX1-LAMP & Pfr364-LAMP PvCOX1-LAMP & PfEMP1-LAMP PvCOX1-LAMP & Pfr364-LAMP PvCOX1-LAMP & PfEMP1-LAMP
P. vivax and P. falciparum infection detected by microscopy & PCR 100.0% 95 CI 85–100% 100.0% 95 CI 85–100% 85.7% 95 CI 66.4–95.3% 85.7% 95 CI 66.4–95.3%
n = 28 n = 28 n = 28 n = 24 n = 24
P. vivax and P. falciparum submicroscopic infection detected only by PCR 80.2% 95 CI 70.8–87.2% 84.2% 95 CI 75.3–90.4% 36.6% 95 CI 27.4–46.86% 34.7% 95 CI 25.64–44.9%
n = 101 n = 81 n = 85 n = 37 n = 35
Non P. vivax and P. falciparum infection detected by Microscopy & PCR 97.3% 95 CI 93.4–99% 96.7% 95 CI 92.7–98.7% 100.0% 95 CI 97.4–100% 100.0% 95 CI 97.4–100%
n = 183 n = 178 n = 177 n = 183 n = 183
Sensitivitya 84.5% 95 CI 78.3–90.7% 87.6% 95 CI 81.9–93.3% 47.3% 95 CI 38.7–55.9% 45.7% 95 CI 37.1–54.3%
Specificitya 97.3% 95CI 94.9–99.6% 96.7% 95 CI 94.1–99.3% 100.0% 95CI 100–100% 100.0% 95CI 100–100%
Agreement Cohen’s Kappaa 0.832 0.769–0.895 0.853 0.794- 0.912 0.513 0.423–0.602 0.497 0.407–0.587
  1. aReference method: real-time PCR described by Mangold et al.[40]