Genetic variation at the Cyp6m2 putative insecticide resistance locus in Anopheles gambiae and Anopheles coluzzii

Table 1 Allele frequencies of non-synonymous variants in Cyp6m2 coding region

Variants			Population allele frequency (%)
Position^a		Ag^b	All	AOcol^c	GHcol	BFcol	CIcol	GNcol	GW	GM	CMgam	GHgam	BFgam	GNgam	GAgam	UGgam	GQgam	FRgam	KE
6928945	G > A	A13T	2.8	39.7	0	0.7	0	0	0	0	0	0	0	0	0	0	0	0	0
6929047	G > C	G47R	0.6	9	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
6929050	T > A	S48T	2.8	9	0.9	4	2.1	0	3.3	2.3	3.2	4.2	2.7	2.5	0	2.2	0	0	0
6929102	A > C	D65A	6.0	0	0	0	0	0	0.5	0	1.9	4.2	2.7	3.8	42.8	2.7	0	0	52.1
6929375	A > T	K156I	0.4	0	0	0	0	0	0	0	0	0	0	0	1.4	0	44.4	0	0
6929506	A > G	N200D	0.4	0	0	0	0	0	0	0	0	0	0	0	1.4	0	44.4	0	0
6929770	T > A	S288T	1.1	0	5.5	0.7	0.7	0	0	0	0.8	4.2	2.7	1.3	0.7	1.3	0	0	0
6929881	G > A	E325K	1.2	0	7.3	3.3	2.1	0	3.8	2.3	0	0	0.5	0	0	0	0	0	0
6929890	G > C	E328Q	2.9	0.6	13.6	7.3	7	12.5	9.9	6.2	0.3	0	0	0	0	0	0	0	0
6929948	A > T	Y347F	2.4	0	0	0	0	0	0	0	0.2	0	0	0	0	1.8	0	0	52.1
6929983	A > G	I359V	16.0	0	4.5	0	7	37.5	16.5	20	19.4	25	17.4	16.3	48.6	19.6	0	0	0
6930206	C > T	P407L	0.7	0	2.7	0.7	7	0	0	0	0.2	0	0	0	0	0	0	0	0
6930242	A > T	E419V	0.4	5.1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
6930269	A > G	K428R	2.0	0	0	0.7	0	0	0.5	0.8	3.5	0	2.7	2.5	0.7	6.3	0	0	0
6930388	G > T	A468S	2.6	0	0	0	0	0	0	0	0.3	0	0	0	42	0	0	0	0

^aPosition relative to the AgamP4 reference sequence, chromosome 3R
^bCodon numbering according to Anopheles gambiae AGAP008212-RA transcript in geneset AgamP4.12
^cAOcol, Angola An. coluzzii; GHcol, Ghana An. coluzzii; BFcol, Burkina Faso coluzzii; CIcol, Côte d'Ivoire An. coluzzii; GNcol, Guinea An. coluzzii; GW, Guinea Bissau; GM,The Gambia; CMgam, Cameroon; GHgam, Ghana An. gambiae; BFgam, Burkina Faso An. gambiae; GNgam, Guinea An. gambiae; GAgam, Gabon An. gambiae; UGgam, Uganda An. gambiae; GQgam, Equatorial Guinea An. gambiae; FRgam, Mayotte An. gambiae; KE, Kenya

ISSN: 1475-2875