Table 3 Prevalence of Pfmdr1 polymorphisms in pre-treatment and post-treatment samples stratified by treatment arms, therapeutic efficacy monitoring, Mali, 2015–2016

Pfmdr1 point mutations

Pfmdr1 codon 86

n = 126

n = 36

n = 120

n = 27

 N86

103 (81.7)

35 (97.2)

0.1954

97 (80.8)

22 (81.5)

0.767

 86N/Y

9 (7.1)

0 (0.0)

5 (4.2)

2 (7.4)

 86Y

14 (11.1)

1 (2.8)

18 (15.0)

3 (11.1)

Pfmdr1 codon 184

n = 144

n = 36

n = 140

n = 26

 Y184

44 (30.6)

7 (19.4)

0.1029

38 (27.1)

5 (19.2)

0.464

 184Y/F

19 (13.2)

0 (0.0)

15 (10.7)

3 (11.5)

 184F

81 (56.3)

29 (80.6)

87 (62.1)

18 (69.2)

Pfmdr1 codon 1246

n = 152

n = 39

n = 146

n = 25

 D1246

149 (98.0)

39 (100.0)

1

144 (98.6)

24 (96.0)

1

 1246D/Y

0 (0.0)

0 (0.0)

0 (0.0)

1 (4.0)

 1246Y

3 (2.0)

0 (0.0)

2 (1.4)

0 (0.0)

Pfmdr1 haplotypes^†

n = 124

n = 35

n = 115

n = 24

 NFD

74 (59.7)

27 (77.1)*

0.014

71 (61.7)

17 (70.8)

1

 NYD

56 (45.2)

7 (20.0)

39 (33.9)

6 (25.0)

 YFD

20 (16.1)

1 (2.9)

19 (16.5)

4 (16.7)

 NFY

0 (0.0)

0 (0.0)

0 (0.0)

1 (4.2)

 NYY

0 (0.0)

0 (0.0)

0 (0.0)

1 (4.2)

 YYD

4 (3.2)

0 (0.0)

2 (1.7)

1 (4.2)

YFY

1 (0.8)

0 (0.0)

0 (0.0)

1 (4.2)

 YYY

2 (1.6)

0 (0.0)

2 (1.7)

1 (4.2)