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Table 2 Metabolites that vary substantially across all datasets at all time points relative to 0 h

From: Inter-study and time-dependent variability of metabolite abundance in cultured red blood cells

Major pathway Subordinate pathway Metabolites Mean (SD)
Amino acids Glutamate metabolism Glutamate 1.74 (0.48)
Glutamate, γ-methyl ester 1.54 (0.33)
Glutathione metabolism Ophthalmate 1.96 (0.58)
5-Oxoproline 1.92 (0.54)
Carbohydrates Fructose, mannose, and galactose metabolism Mannitol/sorbitol 1.99 (0.59)
Fructose 1.69 (0.54)
Glycolysis, gluconeogenesis, and pyruvate metabolism Lactate 2.41 (1.26)
3-Phosphoglycerate 1.76 (0.40)
Phosphoenolpyruvate 1.71 (0.27)
Pentose phosphate pathway Sedoheptulose-7-phosphate 2.93 (1.16)
Cofactors and vitamins Haemoglobin and porphyrin metabolism Heme 1.83 (0.41)
Vitamin B6 metabolism Pyridoxal 2.41 (0.74)
Energy Tricarboxylic acid cycle α-Ketoglutarate 2.19 (0.87)
Lipid Endocannabinoid Oleoyl ethanolamide 2.22 (1.09)
Stearoyl ethanolamide 1.75 (0.44)
Long-chain fatty acid Erucate (22:1n9) 1.72 (0.44)
Peptide Gamma-glutamyl amino acid γ-Glutamylisoleucine 2.33 (0.72)
γ-Glutamylleucine 2.14 (0.59)
γ-Glutamylthreonine 2.10 (0.73)
  1. Metabolites that have \(\stackrel{\mathrm{-}}{\text{m}}\) greater than 1.5. Here, \(\stackrel{\mathrm{-}}{\text{m}}\) represents average value of \(\widehat{\text{m}}\) (shown in Fig. 1D). The average was taken across all datasets and time points (except 0 h). Metabolite identified based on m/z ratio alone with no external standard for validation