Skip to main content

Table 2 Univariable and multivariable analysis of admission features and their association with severe metabolic acidosis

From: Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial

Variable

Sample size: 5425

Univariable analysis

Multivariable analysis

N (%)

Severe Metabolic Acidosis N (%)

Odds ratio

95% CI

P-Value

Odds ratio

95% CI

P Value

Gender: female (reference) and male

2611 (48.1)

1143 (51.3)

      
 

2815 (51.9)

1153 (48.9)

0.91

0.81–1.02

0.11

0.92

0.19–4.55

0.92

Age

5426

 

0.78

0.76–0.81

 < 0.001

0.79

0.76–0.83

 < 0.001

Coma (BCS <  = 2)

1823 (33.6)

776 (50.6)

1.03

0.91–1.16

0.646

1.72

1.17–2.51

0.005

Prostration

2974 (54.8)

1299 (52.3)

1.21

1.07–1.36

0.002

1.88

1.35–2.59

 < 0.001

Convulsions (> 30 min)

169 2(31.2)

623 (43.4)

0.68

0.60–0.77

 < 0.001

0.7

0.53–0.93

0.012

Decompensated shock: systolic BP < 70mhg

178 (3.3)

110 (71.9)

2.62

1.84–3.75

 < 0.001

1.46

0.66–3.32

0.352

Respiratory distress

867 (15.9)

498 (67.8)

2.39

2.03–2.83

 < 0.001

1.46

1.02–2.1

0.039

Deep breathing

938 (17.3)

731 (86.3)

8.74

7.11 –10.74

 < 0.001

3.94

2.51–6.2

 < 0.001

Black water fever (haemoglobinuria)

237 (4.4)

73 (40.6)

0.67

0.49–0.91

0.009

1.28

0.78–2.11

0.34

Symptomatic anaemia

114 (2.1)

55 (56.12)

1.28

0.86–1.92

0.23

   

Anuria / Oliguria

7 (0.1)

7 (100)

1

*

*

   

Hyperparasitaemia

100 (1.8)

40 (42.6)

0.73

0.48–1.11

0.14

   

Mild anaemia (< 10—5)

2705 (55.0)

1139 (45.3)

1.21

1.02–1.43

0.027

0.73

0.54–0.98

0.04

Severe anaemia (< 5)

1431 (29.1)

841 (64.2)

2.6

2.16–3.13

 < 0.001

0.79

0.55–1.12

0.19

Uraemia (BUN > 20)

1110 (24.3)

800 (73.4)

3.55

3.05-–4.13

 < 0.001

   

Hypoglycaemia

557 (10.3)

434 (88.4)

9.11

6.87–12.09

 < 0.001

5.16

2.74–9.75

 < 0.001

  1. Respiratory distress = costal in drawing/ recession / respiratory insufficiency; Hyperparasitaemia =  > 500 Parasites per high power field