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Table 2 Univariable and multivariable analysis of admission features and their association with severe metabolic acidosis

From: Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial

Variable Sample size: 5425 Univariable analysis Multivariable analysis
N (%) Severe Metabolic Acidosis N (%) Odds ratio 95% CI P-Value Odds ratio 95% CI P Value
Gender: female (reference) and male 2611 (48.1) 1143 (51.3)       
  2815 (51.9) 1153 (48.9) 0.91 0.81–1.02 0.11 0.92 0.19–4.55 0.92
Age 5426   0.78 0.76–0.81  < 0.001 0.79 0.76–0.83  < 0.001
Coma (BCS <  = 2) 1823 (33.6) 776 (50.6) 1.03 0.91–1.16 0.646 1.72 1.17–2.51 0.005
Prostration 2974 (54.8) 1299 (52.3) 1.21 1.07–1.36 0.002 1.88 1.35–2.59  < 0.001
Convulsions (> 30 min) 169 2(31.2) 623 (43.4) 0.68 0.60–0.77  < 0.001 0.7 0.53–0.93 0.012
Decompensated shock: systolic BP < 70mhg 178 (3.3) 110 (71.9) 2.62 1.84–3.75  < 0.001 1.46 0.66–3.32 0.352
Respiratory distress 867 (15.9) 498 (67.8) 2.39 2.03–2.83  < 0.001 1.46 1.02–2.1 0.039
Deep breathing 938 (17.3) 731 (86.3) 8.74 7.11 –10.74  < 0.001 3.94 2.51–6.2  < 0.001
Black water fever (haemoglobinuria) 237 (4.4) 73 (40.6) 0.67 0.49–0.91 0.009 1.28 0.78–2.11 0.34
Symptomatic anaemia 114 (2.1) 55 (56.12) 1.28 0.86–1.92 0.23    
Anuria / Oliguria 7 (0.1) 7 (100) 1 * *    
Hyperparasitaemia 100 (1.8) 40 (42.6) 0.73 0.48–1.11 0.14    
Mild anaemia (< 10—5) 2705 (55.0) 1139 (45.3) 1.21 1.02–1.43 0.027 0.73 0.54–0.98 0.04
Severe anaemia (< 5) 1431 (29.1) 841 (64.2) 2.6 2.16–3.13  < 0.001 0.79 0.55–1.12 0.19
Uraemia (BUN > 20) 1110 (24.3) 800 (73.4) 3.55 3.05-–4.13  < 0.001    
Hypoglycaemia 557 (10.3) 434 (88.4) 9.11 6.87–12.09  < 0.001 5.16 2.74–9.75  < 0.001
  1. Respiratory distress = costal in drawing/ recession / respiratory insufficiency; Hyperparasitaemia =  > 500 Parasites per high power field