Skip to main content

Table 1 Effects of P. berghei K173 infection on some haematological parameters in infected mice on 5 dpi

From: Analysis of spleen histopathology, splenocyte composition and haematological parameters in four strains of mice infected with Plasmodium berghei K173

Haematological parameters C57BL/6 BALB/c ICR KM
uninfected Infected uninfected Infected uninfected Infected uninfected Infected
PLT (109/L) 1278.83 ± 89.60 285.00 ± 34.88↓*** 1310.50 ± 57.76 312.33 ± 19.59↓*** 1635.67 ± 68.14 296.00 ± 33.80↓*** 1476.17 ± 99.99 341.33 ± 31.87↓***
RBC (1012/L) 10.01 ± 0.25 7.75 ± 0.62↓*** 7.93 ± 1.01 6.62 ± 0.37↓* 8.16 ± 0.16 3.39 ± 0.35↓*** 8.64 ± 0.29 4.44 ± 0.34↓***
HGB (g/L) 149.67 ± 2.66 113.83 ± 8.45↓*** 132.33 ± 12.07 101.50 ± 4.42↓* 137.17 ± 4.26 60.00 ± 6.96↓*** 129.67 ± 5.98 68.83 ± 4.92↓***
HCT (%) 47.23 ± 0.96 37.78 ± 3.03↓*** 40.40 ± 3.28 32.58 ± 1.33↓* 42.48 ± 1.10 21.27 ± 2.19↓*** 42.67 ± 2.02 24.77 ± 1.86↓***
MCV (fL) 46.52 ± 0.43 48.40 ± 0.71↑*** 45.02 ± 0.67 49.22 ± 1.48↑* 51.77 ± 1.33 62.72 ± 3.15↑*** 48.75 ± 0.83 56.26 ± 1.12↑***
MCH (pg) 14.71 ± 0.07 14.56 ± 0.24 14.73 ± 0.15 15.46 ± 0.63↑* 16.86 ± 0.35 17.55 ± 0.76 15.18 ± 0.35 15.75 ± 0.12↑*
MCHC (g/L) 316.83 ± 2.04 301.17 ± 2.14↓*** 327.17 ± 4.35 310.50 ± 5.17↓*** 321.67 ± 3.26 283.83 ± 5.49↓*** 310.67 ± 3.38 279.00 ± 5.66↓***
RDW-CV (%) 17.35 ± .26 16.20 ± 0.83↓* 19.03 ± 0.99 16.72 ± 0.92↓* 15.85 ± 0.32 19.97 ± 1.21↓* 16.75 ± 0.57 15.83 ± 1.64
RDW-SD (fL) 22.80 ± 0.59 24.50 ± 1.16↑* 25.82 ± 2.22 26.87 ± 1.49 26.70 ± 0.84 41.11 ± 4.13↑*** 27.27 ± 0.74 31.98 ± 1.85↑***
WBC (109/L) 2.74 ± 0.39 5.84 ± 2.16↑* 4.37 ± 0.93 8.64 ± 1.95↑* 2.52 ± 0.35 5.63 ± 1.64↑* 1.65 ± 0.30 3.45 ± 0.43↑***
NEUT (%) 10.13 ± 0.4 88.33 ± 5.83↑*** 32.68 ± 9.50 76.53 ± 10.66↑*** 16.50 ± 1.07 91.65 ± 2.59↑*** 14.78 ± 1.31 94.77 ± 1.04↑***
LYMPH (%) 82.80 ± 2.78 5.71 ± 3.13↓*** 52.68 ± 9.16 --- 73.98 ± 1.77 --- 74.57 ± 2.09 ---
MONO (%) 6.35 ± 1.55 5.68 ± 2.45 2.10 ± 0.38 7.00 ± 2.46↑* 4.66 ± 0.85 2.71 ± 0.85↓* 4.85 ± 1.01 3.11 ± 0.46↓*
EO (%) 1.47 ± 0.67 0.47 ± 0.38↓* 2.13 ± 0.59 1.33 ± 0.68 4.06 ± 0.53 3.98 ± 2.73 4.60 ± 1.66 0.71 ± 0.24↓*
BASO (%) 0.32 ± 0.23 0.63 ± 0.23 0.16 ± 0.05 0.38 ± 0.04↑* 0.25 ± 0.20 0.45 ± 0.08 0.51 ± 0.17 0.58 ± 0.20
  1. Values are given as mean ± SD (n = 6). * and *** indicate p < 0.05 and p < 0.001 compared with the uninfected group, respectively. “---” indicates that the blood analyser did not obtain the haematological parameters
  2. PLT platelet, RBC red blood cell, HGB haemoglobin, HCT haematocrit, MCV mean corpuscular volume, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, RDW-CV RBC distribution width coefficient of variation, RDW-SD RBC distribution width standard deviation, WBC white blood cell, NEUT neutrophil, LYMPH lymphocyte, MONO monocyte, EO eosinophil, BASO basophil