Table 2 In vivo efficacy studies in Guinea

Chloroquine

 Turaman-1992 [6]

10 mg/kg on day0 and day1 and 5 mg/kg on day2

1991

Kouroussa

 < 14 years

44

Day1 PPR: 100%

Day2 PPR: 100%

Day7 PPR: 27% (12/44)

32 (73%) showed a good response (RI); 12 (27%) with RI/RII resistance on day 7

 WHO-2005 [25] (the report summarizes data from 8 in vivo studies)

–

1996–2001

–

–

–

–

Median failure rate of 15.6% [range: 7.7–28.3%]

 Loua-2017 [26]

10 mg/kg on day0 and day1 and 5 mg/kg on day2

2007

Dubreka

5–15 years

24

^a

Only 4/21 (19%) patients achieved parasite clearance by day28

Artesunate-amodiaquine

 Bonnet-2007 [18]

AQ dose: 30 mg/kg over 3 days

AS dose: 12 mg/kg AS over 3 days

2004

Dabola

6–59 months

110

–

Day28 PCR corrected efficacy: 99.5% [95% CI: 94.7–99.8]

 WANECAM-2018 [28]

25:67.5 mg tablet: (≥ 5 to < 9 kg 1 tablet); 50:135 mg tablet:(≥ 9 to < 18 kg 1 tablet); 100:270 mg tablet: (> 18 to < 36 kg 1 tablet; ≥ 36 kg 2 tablets)

2011–2016

Mafèrinyah

 ≥ 6 months

311

–

Day28 efficacy: 100%^b

Day42 efficacy: > 99%^b

 Beavogui-2020 [5]

–

2016

Mafèrinyah

6–59 months

107

Day2 PPR: 10.5%

Day3 PPR: 1%

100% (day28 K-M estimates)

 Beavogui-2020 [5]

–

2016

Labé

6–59 months

104

Day2 PPR: 4.8%

day3 PPR: 0%

day28 efficacy: 99% [95% CI: 97.2–100] (K-M estimates)

Artesunate-SP

 Bonnet-2007 [18]

–

2004

Dabola

6–59 months

110

–

Day28 efficacy: 99.0% [95% CI: 94.5–99.8]

(PCR corrected)

Artemether-lumefantrine

 Beavogui-2020 [5]

–

2016

Mafèrinyah

6–59 months

104

Day2 PPR: 11.9%

Day3 PPR: 0%

Day28 efficacy: 100% (K–M estimates)

 Beavogui-2020 [5]

–

2016

Labé

6–59 months

105

Day2 PPR: 9.7%

Day3 PPR: 0%

Day28 efficacy: 99.0% [95% CI: 97.1–100] (K–M estimates)

Pyronaridine Artesunate

 WANECAM-2018 [28]

60:20 mg sachet: (5 to < 8 kg 1 sachet; 8 to < 15 kg 2 sachets; 15 to < 20 kg 3 sachets); 180:60 mg sachet: (20 to < 24 kg 1 sachet; 24 to < 45 kg 2 sachets; 45 to < 65 kg 3 sachets; ≥ 65 kg 4 sachets)

2011–2016

Mafèrinyah

 ≥ 6 months

235

–

Day28 efficacy: 100%^b

Day42 efficacy: 99%^b

Dihydroartemisinin piperaquine

 WANECAM-2018 [28]

20:160 mg tablet (5 to < 7 kg 1/2 tablet; 7 to < 13 kg 1 tablet); 40:320 mg tablet (13 to < 24 kg 1 tablet; 24 to < 36 kg 2 tablets; 36 to < 75 kg 3 tablets)

2011–2016

Mafèrinyah

 ≥ 6 months

309

–

Day28 efficacy: 99.8%^b

Day42 efficacy: 99.5%^b