Humoral and cellular immune response to Plasmodium vivax VIR recombinant and synthetic antigens in individuals naturally exposed to P. vivax in the Republic of Korea

Table 3 Median concentration (pg/ml) values for each cytokine and growth factor in plasma of P. vivax-infected and uninfected groups

	IL-2	IL-6	IL-10	IL-12	IFN- γ	TNF	IP-10	G-CSF
VIR25
P. vivax	10	27	34	42	14	62	10	98
Healthy control	13	19	31	46	11	56	12	102
P values	0.225	0.092	0.103	0.312	0.098	0.236	0.168	0.263
VIR-C2
P. vivax	89**	41*	102*	74*	13	112*	12	195*
Healthy control	11	20	33	42	12	64	9	112
P values	< 0.001	0.029	0.018	0.035	0.156	0.031	0.264	0.039
PvLP1
P. vivax	7	29	52	40	11	72	13	124
Healthy control	10	12	39	41	12	69	10	96
P values	0.265	0.314	0.247	0.184	0.206	0.105	0.241	0.198
PvLP2
P. vivax	32*	72*	132**	61	13	103*	13	159*
Healthy control	12	19	49	49	11	64	15	95
P values	0.045	0.013	< 0.001	0.235	0.153	0.031	0.128	0.015
PvMSP1-19
P. vivax	125^**	95**	89**	58	15	120*	49	201*
Healthy control	16	14	39	46	13	62	45	106
P values	< 0.001	< 0.001	< 0.001	0.391	0.153	0.013	0.364	0.041
GST
P. vivax	10	25	38	51	14	67	10	116
Healthy control	12	16	31	41	12	62	11	102
P values	0.125	0.312	0.186	0.216	0.234	0.163	0.113	0.265
Medium
P. vivax	10	39	35	50	13	70	10	121
Healthy control	16	15	32	45	15	68	9	110
P values	0.315	0.132	0.327	0.192	0.264	0.162	0.298	0.225

ISSN: 1475-2875