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Fig. 6 | Malaria Journal

Fig. 6

From: Mechanistic within-host models of the asexual Plasmodium falciparum infection: a review and analytical assessment

Fig. 6

Example of asexual parasite densities, immune responses, and multiplication rates in single simulations from different models. Each panel shows, from top to bottom, 1. the log10 asexual density and variant specific asexual parasite density, with the horizontal dashed black line indicates the threshold of positive density (10 PBRC/μl); 2. The stacked magnitude (as the \(|{\mathrm{log}}_{2}\left({\mathrm{R}}_{\mathrm{t}}+1\right)|\) with \({\mathrm{R}}_{\mathrm{t}}\) the effect of each immune response) of the innate (orange), variant specific (red), and general adaptive (yellow) immune responses, with 1 representing maximum effect and 0 no effect for each immune response type; and 3. The overall (across variants, see Methods) multiplication rate, with the horizontal dashed line representing a multiplication rate of 16. The x-axis represents days of infection. Results are shown for a Molineaux et al., b. Johnston et al., c Challenger et al., d Gatton and Cheng, and e Eckhoff

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