Assumptions on innate immune response
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Dependent on total parasite density at a given time
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Dependent on density of each parasites expressing variants for which there is no antibody response, and on the rupturing of iRBCs
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Dependent on total parasite density at a given time and is capped by a maximum efficacy term
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Dependent on iRBC density
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Dependent on cumulative asexual parasite density
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Assumptions on variant specific immune response
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Dependent on the variant specific parasite density, and lasting in time with a decaying intensity
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Dependent on the total parasite within a time frame preceding the time of response, and on time after infection start
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Triggered by a variant specific parasite density threshold, dependent on the time after infection start, and the magnitude increases if the antibody has been produced previously
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Dependent on the variant specific parasite density
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Dependent on the variant specific parasite density, a maximum growth and decay rate, and is restricted by total number of immune cells available
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Not explicit, but adaptive immune response includes random falls due to implicit variant switching
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–
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Assumptions on general adaptive immune response
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Depends on cumulative total parasite density
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Dependent on the time after the start of the infection
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Modelled as immune response against merozoite antigens, increase every 2 days, dependent on parasite density
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Dependent on cumulative number or days the total parasite population is above 107
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Dependent on iRBC density and combined innate and adaptive effector pool
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Dependent on cumulative asexual parasite density, does not decay in time
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Includes cross-reactivity
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No
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Not explicitly
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Yes, the variant specific response approximately kills 5% of all other variants
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Yes, response to variants randomly assigned to 5 subgroups
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Yes, response to variants randomly assigned to subgroups
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No
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Yes, immune response to one genotype can be activated by the presence of another genotype
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Other comments
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Innate and adaptive immune response include patient specific parameters
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Parameters differ with different parasite strains
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Immune memory is included in the model
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Detailed sensitivity analysis resulted in significant impact on the model’s outcome of small changes in parameter values, highlighting the challenged face by within host models
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