Fig. 1
From: The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations
SNPs within protein–protein interacting regions of BSG, Rh5, CyRPA and Ripr. The interacting crystal structures of BSG (grey), Rh5 (yellow), CyRPA (green) and Ripr alpha helix (black) showing SNPs that fall within protein–protein interacting regions. In red, are the polymorphic residues identified in codon C203Y of Rh5 and codon D302E and F292V of CYPRA. Of the SNPs identified in the Rh5-CyRPA structure only the high frequency Rh5 codon 203 falls in the region that interacts with BSG. The singleton SNPs in codon F292V and D302E denoted by a hash#, lie within the region that interacts with Ripr. Apart from the short α-helical structure, the Ripr structure was not available on Protein Data Bank