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Table 4 The frequency of variants in the Rh5 complex genes identified by CS and WGS

From: The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations

Gene Position S/NS/Indel Frequency Gene Position S/NS/Indel Frequency
CS WGS CS WGS
Rh5 Rh5_42 NS 2.3# 0 CyRPA CyRPA_101 S 0 4.1
Rh5_147* NS 20.5 22.6 CyRPA_160* NS 0 0.7#
Rh5_148* NS 20.5 22.6 CyRPA_165* NS 2.2 0.7#
Rh5_203* NS 13.6 10.3 CyRPA_229 NS 0 1.4#
Rh5_365* NS 0 0.7# CyRPA_235* NS 0 0.7
Rh5_371* NS 0 4.1 CyRPA_236 NS 0 3.4#
Rh5_389* NS 0 0.7# CyRPA_270* NS 0 2.8
Rh5_407* NS 0 0.7# CyRPA_271* NS 2.3 0
Rh5_410* NS 4.6 3.4 CyRPA_292* NS 1.2# 0
Rh5_429* NS 29.6 34.9 CyRPA_302* NS 1.2# 2.1
Rh5_439*# NS 0 1.4 CyRPA_17* NS 0 0.7#
P113 p113_5* NS 0 1.4 CyRPA_19* NS 0 0.7#
p113_7* S 0 5.1# Ripr RIPR_3 NS 0 1.4
p113_234* NS 1.1 1.4 RIPR_66* NS 0 0.7#
p113_267* NS 4.4 7.5 RIPR_119 NS 0 0.7#
p113_275_3N Indel 2.2 0 RIPR_190* NS 7.6 10.3
p113_275_6N Indel 72.5 0 RIPR_215* NS 0 2.7
p113_275_7N Indel 1.1 0 RIPR_220 NS 1.5 0
p113_275_8N Indel 23.1 0 RIPR_226* NS 3.0 0
p113_275_9N Indel 1.1 0 RIPR_228* S 0 0.7#
p113_310 NS 3.3 3.4 RIPR_255 NS 1.5 2.8
p113_330* NS 1.1# 0 RIPR_259* NS 27.3 23.6
p113_345* S 0 1.4# RIPR_327* NS 4.6 3.4
p113_381* S 0 0.7# RIPR_429 NS 0 0.7#
p113_421* NS 1.1# 0 RIPR_436* NS 0 0.7#
p113_453* S 0 1.4# RIPR_438* NS 0 0.7#
p113_478 NS 0 0.7# RIPR_524* NS 12.1 0.7#
p113_485* NS 0 1.4# RIPR_564 NS 1.5# 0
p113_620 NS 3.3 0 RIPR_587 NS 1.5 0
p113_713* NS 2.2 0 RIPR_744* S 0 0.7#
p113_716 NS 2.2# 0 RIPR_843 NS 0 1.4
p113_750 S 0 0.7# RIPR_858* NS 0 0.7#
p113_758* NS 1.1 2.1 RIPR_883* NS 0 0.7#
p113_849 NS 1.1# 0 RIPR_985* NS 12 8.9
p113_859_2E Indel 3.3 0 RIPR_995* NS 0 1.4#
p113_859_3E Indel 96.7 0 RIPR_1003* NS 15.4 10.3
p113_912* NS 0 1.4# RIPR_1039* NS 12 2.7
p113_935* NS 0 0.7#      
  1. CyRPA: 12 SNPs, p113: 27 SNPs, Ripr: 25 SNPs and Rh5: 11 SNPs. SNPs that were identified by either CS or WGS and present in the global MalariaGEN dataset are indicated by an asterix* and singleton SNPs are indicated by a hash #