Skip to main content
Fig. 1 | Malaria Journal

Fig. 1

From: Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

Fig. 1

Relative fitness of parasites with varied PfMDR1 sequences. Combinations of PfMDR1 N86Y and Y184F haplotypes were co-cultured in competitive growth experiments, beginning with equal quantities of the two lines, and relative fitness was assessed based on the prevalence of each genotype over 40 days, with the percentage of wild type shown for the loci that differed between the two lines. Each line is designated based on the amino acid at positions 86 and 184. Co-culture experiments demonstrated three lines in equipoise (A, D, F), overgrowth of mutant parasites (B), overgrowth of wild-type parasites (E), and selection of wild type/mixed 86Y/Y184 parasites (C). * Indicates combinations with statistically significant selection coefficients

Back to article page