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Fig. 3 | Malaria Journal

Fig. 3

From: Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

Fig. 3

Impact of anti-malarials on fitness of parasites with varied PfMDR1 sequences. With wild-type fixed at PfMDR1 184, parasites wild-type or mutant at 86 (NY vs. YY) were co-cultured in the presence of the indicated concentrations of chloroquine (A), lumefantrine (B), or piperaquine (C) and the prevalence of each genotype was followed over 36 days. It is seen that mutant parasites are favored under chloroquine pressure, wild type parasites are favored under lumefantrine pressure, and that there is no clear impact on genotype prevalence under piperaquine pressure

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