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Table 3 In vitro growth selection coefficients for PfMDR1 variants (NY vs. YY) co-cultured in the presence of anti-malarials

From: Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

Drug exposure

s

P s

Pd

No drug

− 0.02

0.20

-

Chloroquine

   

 80 nM, 25% IC50

− 0.04

0.0006

0.67

 160 nM, 50% IC50

− 0.08

0.001

0.03

Lumefantrine

   

 0.5 nM, 25% IC50

0.49

0.003

< 0.0001

 1 nM, 50% IC50

0.43

0.0008

< 0.0001

Piperaquine

   

 9 nM, 25% IC50

− 0.05

0.08

0.63

  1. Analysis was as described for Table 1. Ps, P value for comparison of s to 0. Pd, P value for comparison of s for assays performed in the presence or absence of anti-malarials. Ps was determined using one-way ANOVA. Pd was determined using two-way ANOVA with Tukey’s post-hoc test
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Malaria Journal

ISSN: 1475-2875

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