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Table 3 In vitro growth selection coefficients for PfMDR1 variants (NY vs. YY) co-cultured in the presence of anti-malarials

From: Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum

Drug exposure s P s Pd
No drug − 0.02 0.20 -
Chloroquine    
 80 nM, 25% IC50 − 0.04 0.0006 0.67
 160 nM, 50% IC50 − 0.08 0.001 0.03
Lumefantrine    
 0.5 nM, 25% IC50 0.49 0.003 < 0.0001
 1 nM, 50% IC50 0.43 0.0008 < 0.0001
Piperaquine    
 9 nM, 25% IC50 − 0.05 0.08 0.63
  1. Analysis was as described for Table 1. Ps, P value for comparison of s to 0. Pd, P value for comparison of s for assays performed in the presence or absence of anti-malarials. Ps was determined using one-way ANOVA. Pd was determined using two-way ANOVA with Tukey’s post-hoc test