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Table 3 Blood transcriptional modules enriched in overlapping differentially expressed genes

From: Early whole blood transcriptional responses to radiation-attenuated Plasmodium falciparum sporozoite vaccination in malaria naïve and malaria pre-exposed adult volunteers

N genes N BTM N shared N expected p value FDR Blood transcriptional module (BTM) name Protection associated
377 82 26 2 4.58E−21 3.01E−18 DC.M3.1_Erythrocytes  
377 145 32 4 2.55E−20 8.35E−18 LI.M4.1_cell cycle (I) *
377 335 44 9 3.53E−18 7.72E−16 LI.M4.0_cell cycle and transcription *
377 49 17 1 6.00E−15 9.84E−13 DC.M3.3_Cell Cycle *
377 77 20 2 1.31E−14 1.71E−12 DC.M4.4_Undetermined  
377 34 14 1 9.42E−14 1.03E−11 LI.M4.2_PLK1 signaling events *
377 200 29 6 1.89E−13 1.77E−11 HALLMARK_E2F_TARGETS *
377 200 27 6 7.41E−12 6.08E−10 HALLMARK_HEME_METABOLISM  
377 71 16 2 6.30E−11 4.59E−09 DC.M2.3_Erythrocytes  
377 35 11 1 1.36E−09 8.91E−08 LI.M4.5_mitotic cell cycle in stimulated CD4 T cells  
377 200 23 6 6.65E−09 3.97E−07 HALLMARK_G2M_CHECKPOINT  
377 51 10 1 1.03E−06 5.61E−05 LI.M103_cell cycle (III)  
377 32 8 1 1.79E−06 9.05E−05 LI.M6_mitotic cell division  
377 47 9 1 4.42E−06 2.07E−04 LI.M49_transcription regulation in cell development  
377 12 5 0 1.03E−05 4.53E−04 LI.M4.12_C-MYC transcriptional network  
377 20 6 1 1.16E−05 4.77E−04 DC.M6.11_Cell Cycle  
377 21 6 1 1.59E−05 6.13E−04 LI.M4.7_mitotic cell cycle  
377 14 5 0 2.50E−05 9.11E−04 LI.M4.10_cell cycle (II) *
377 97 11 3 7.04E−05 2.43E−03 DC.M5.3_Undetermined  
377 245 18 7 1.51E−04 4.97E−03 DC.M5.5_Undetermined  
377 59 8 2 1.98E−04 6.18E−03 DC.M4.14_Monocytes  
377 34 6 1 2.91E−04 8.68E−03 DC.M7.31_Undetermined  
377 14 4 0 4.53E−04 1.29E−02 LI.M173_erythrocyte differentiation  
377 26 5 1 6.26E−04 1.71E−02 DC.M8.26_Undetermined  
377 16 4 0 7.88E−04 2.07E−02 LI.M4.9_mitotic cell cycle in stimulated CD4 T cells *
377 17 4 0 1.01E−03 2.45E−02 LI.M19_T cell differentiation (Th2)  
377 17 4 0 1.01E−03 2.45E−02 LI.M136_TBA  
377 33 5 1 1.93E−03 4.52E−02 LI.M10.0_E2F1 targets (Q3)  
377 10 3 0 2.14E−03 4.85E−02 LI.M4.14_Rho GTPase cycle  
377 11 3 0 2.89E−03 5.74E−02 LI.M4.15_enriched in monocytes (I)  
377 11 3 0 2.89E−03 5.74E−02 LI.M12_CD28 costimulation  
377 11 3 0 2.89E−03 5.74E−02 LI.M33_inflammatory response  
377 11 3 0 2.89E−03 5.74E−02 LI.M171_heme biosynthesis (I)  
377 12 3 0 3.77E−03 7.28E−02 LI.M4.11_mitotic cell cycle in stimulated CD4 T cells  
377 13 3 0 4.81E−03 9.01E−02 LI.M15_Ran mediated mitosis  
  1. Hypergeometric p-values and overlap sizes for blood transcriptional modules enriched in shared IMRAS and BSPZV1 upregulated DEGs. BTMs enriched in the 14-gene protection associated subset are indicated by as asterisk (*)