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Table 1 Different sub-populations of phagocytes and their phagocytic ability in malaria

From: Factors influencing phagocytosis of malaria parasites: the story so far

Phagocyte population Surface marker expression Origin Phagocytic ability References
Parasite species Phagocytic ability
Monocytes
 Classical monocytes CD14brightCD16 Human P. falciparum IEs Intermediate/inflammatory > non-classical > classical [5, 10]
 Intermediate/inflammatory monocytes CD14brightCD16+
 Non-classical monocytes CD14dimCD16+
Macrophages
 Splenic macrophages CD11bhighCD14+F4/80+TCRβ+ Mouse P. berghei IEs Higher phagocytic potential compared to TCRβ macrophages [53]
CD11b+Tim3+ Mouse P. berghei IEs Reduced phagocytic ability due to Tim3 expression [55]
Neutrophils
 TCRβ+ neutrophils CD11b+ Ly6G+TCRβ+ Mouse P. berghei IEs Higher phagocytic potential compared to TCRβ neutrophils [79]
 Low density neutrophils CD66b+CD16+CD11b+CD15+ Human P. vivax-infected reticulocytes Comparable phagocytic potential to high density neutrophils from malaria patients, higher phagocytosis ability compared to high density neutrophils from healthy donors [76]