Table 1 Composition of liposomes used as passive targeting drug delivery systems in malaria therapy

Primaquine

EPC: PS: cholesterol

4:1:5

[110, 113,114,115,116]

Chloroquine

Fluid-state

[117,118,119,120]

 PC: PG: cholesterol

10:1:5

Gel-state

 DSPC: DPPG: cholesterol

10:1:5

10:1:10

Primaquine

Leu-primaquine

Ala-leu-primaquine

Ala-leu-ala-leu-primaquine

Fluid-state

[121]

 CHEMS: cholesterol: PL100

1:4:10

 CHEMS: cholesterol: PL90G

1:4:10

 CHEMS: cholesterol: PL100

1:2:7

 CHEMS: cholesterol: PL90G

1:2:7

 CHEMS: PL100

1:10

 CHEMS: PL90G

1:10

 CHEMS: PL100

1:7

 CHEMS: PL90G

1:7

Gel-state

 CHEMS: cholesterol: PL100H

1:4:10

 CHEMS: cholesterol: DPPC

1:4:10

 CHEMS: cholesterol: PL100H

1:2:7

 CHEMS: cholesterol: DPPC

1:2:7

 CHEMS: PL100H

1:10

 CHEMS: DPPC

1:10

 CHEMS: PL100H

1:7

 CHEMS: DPPC

1:7

Arteether

DMPC

DMPC: DPPC

DMPC: DPPC: cholesterol

EPC

EPC: cholesterol

EPC: cholesterol

DPPC

DPPC: DBPC: cholesterol

DPPC: DBPC: cholesterol

DPPC: DBPC: cholesterol

DPPC: DBPC: cholesterol

1

1:1

1:1:1

1

1:0.5

1:1

1

1:1:1

1:1:2

1:1:2

0:1:1

[122]

Arteether

DPPC: DBPC: cholesterol

1:1:2

[123]

Desferrioxamine

EPC: EPG^c

EPC: EPG: cholesterol^d

DSPC: DPPG: cholesterol^e

10:1

10:1:4

10:1:4

[124]

β-artemether

EPC: cholesterol

1:0

1:1

2:1

3:1

4:1

3:2

4:3

[125]

Artesunate

EPC: cholesterol

4:3

[126]

Chloroquine

SPC: cholesterol

10:0

10:1

8:1

5:1

4:1

3:1

[127]

Artemisinin

Artemisinin + Curcumin

PL90G: cholesterol

5:0.6

1.6:0.2

[128, 129]

PL90G: cholesterol: DSPE-mPEG2000

5:0.6:0.25

1.6:0.2:0.1

–

SPC: phophatidic acid

SPC: stearylamine

SPC: stearic acid

SPC: stearyl alcohol

SPC: myristic acid

80:20

[130]

SPC: Stearylamine: cholesterol: DSPE-mPEG2000

80:20 ^b

Curcumin

SPC

100

[131]

β-methasone hemisuccinate

HSPC: cholesterol: DSPE-PEG2000

55:40:5

[132, 133]

Monensin

Doxycycline

SPC: cholesterol

SPC: cholesterol: stearylamine

SPC: cholesterol: DSPE-mPEG2000

SPC: cholesterol: stearylamine: DSPE-mPEG2000

7:3

7:3 (± 10 mol %)

7:3 (± 0.5–5 mol %)

7:3 (± 10 mol % ± 0.5–5 mol %)

[134, 135]

Indocyanin Green

PL S75: cholesterol

PL S75: cholesterol: DSPE-mPEG2000

9:1 (w/w)

9:1:1.33 (w/w)

[136]

Platinum-chloroquine diphosphate dichloride

HSPC: cholesterol: DSPE-mPEG2000: DOTAP

55:45:5:0

50:45:5:5

45:45:5:10

40:45:5:15

35:45:5:20

[137]

Maduramicin

SPC: cholesterol (± DSPE-mPEG2000)

7:3 (± 5 mol %)

[138]

Primaquine + Chloroquine

HSPC: cholesterol: DSPE-mPEG2000

55:45:5

[139]