From: Liposomes for malaria management: the evolution from 1980 to 2020
Drugs | Lipid composition | Ratioa | Ligands | References |
---|---|---|---|---|
– | DMPC: cholesterol: dicetylphosphate PC: sphingomyelin: cholestrol: dicetylphosphate | 1:0.7:0.11 0.8:0.2:0.75:0.11 | Glycolipids | [163] |
– | EPC: cholesterol: gangliosides | 20:20:4 | Anti-rat erythrocyte F(ab’)2 | [165] |
– | EPC: cholesterol | 1:1 | Tuftsin derivatives | [166] |
Chloroquine | EPC: cholesterol: gangliosides | 20:20:4 | Anti-mouse erythrocyte F(ab’)2 | [167] |
Chloroquine | PC: PS: cholesterol PC: PS: cholesterol: MPB-PE | 9.5:1:10 9.5:1:10:0.5 | Anti-mouse erythrocyte F(ab’)2 | |
Chloroquine | EPC: cholesterol: gangliosides | 20:20:4 | Anti-mouse erythrocyte F(ab’)2 | [171] |
Chloroquine | EPC: cholesterol: gangliosides | 20:20:4 | MAbF10 MAbD2 | [140] |
– | Lipid  di22: 1-PC(1,2-dieucoyl-sn-3-PC), Lipid-PEG-conjugate  di22: 1-PE-PEG5000(1,2-dierucoyl-sn-3-(PEG5000)-PE, Lipid-PEG-peptide-conjugate  di22: 1-AP-PEG3400-peptide(1,2-dierucoyl-sn-3-(PEG3400-succinyl-peptide)-aminopropane, Fluorescent lipid  di22: 1-AP-Bodipy-TR-X(1,2-dierucoyl-sn-3-(Bodipy-TR-X)-aminopropane) | 82:10:4:4b 87:7:2:4 91:4:1:4 86:10:4:0 | 19-Aminopeptide from the CSP of P. berghei | |
Chloroquine Fluorescent probe pyranine 655 ITK® carboxyl quantum dots | DOPC: cholesterol DOPC: cholesterol: MPB-PE | 80:20 77.5:20:2.5 80:20 | BM1234 | [175] |
Chloroquine Fosmidomycin | DOPC: cholesterol DOPC: cholesterol: MPB-PE | 80:20 77.5:20:2.5 | BM1234 | [176] |
Chloroquine | DOPC: cholesterol DSPC: cholesterol DOPC: cholesterol: DSPE-PEG-Mal DSPC: cholesterol: DSPE-PEG-Mal DOPC: cholesterol: MPB-PE | 80:20 90:10 75:20:5 85:10:5 65:20:15 | Anti-MAHRP121-40 Anti-HRP2 Anti-GPA | [177] |
– | DSP: cholesterol: DSPE-mPEG | 2:1:0.1 | PSP | [24] |
Lumefantrine | DSPC: cholesterol: DSPE-mPEG2000 | 85:10:5 | NTS-DBL1α N-terminal domain of a rosetting PfEMP1 | [178] |
Chloroquine, 7c, 7d (4-aminoquinoline compounds) Primaquine Quinine, BCN-01, BCN-02 (aminoalcohol compounds) Tafenoquine | DSPC: cholesterol: DSPE-PEG2000-Mal DOPC: cholesterol: DSPE-PEG2000-Mal | 85:10:5 | Mouse monoclonal IgG2b anti-human GPA (SM3141P) Rat monoclonal IgG2b anti-mouse TER-119 (AM31858PU-N) | [179] |
Primaquine | DOPC: PE: cholesterol: DOTAP | 46:30:20:4 | Heparin | [180] |
Pyronaridine + Atovaquone | DOPC: cholesterol: DSPE-PEG2000 POPC: cholesterol: DSPE-PEG2000 DSPC: cholesterol: DSPE-PEG2000 | 75:20:5 | Anti-GPA | [181] |
Poupartone B | DOPC: cholesterol: DOTAP | 76:20:4 | Heparin | [182] |