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Table 1 In vitro antiplasmodial activity of African medicinal plants

From: Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature

Plant species Plant family Source Country of study Part of plant used Extraction solvent Antiplasmodial Activity IC50 or ED50 or LD50 Strain of Plasmodium Tested Toxicity (value; assay)
Dicoma anomala subsp. Gerrardii Compositae [19] South Africa Whole plant Methanol, Water, Hexane, Dichloromethane Very gooda 1.865 µM IC50 Plasmodium falciparum 3D7, D10 Nd
Abutilon grandiflorum Malvaceae [20] Tanzania Roots Ethyl Acetate Moderate 10 µg/ml IC50 Plasmodium falciparum K1 Nd
Acacia mellifera Fabaceae [21] Kenya Inner Barks Methanol Very Good 4.48 µg/ml IC50 Plasmodium falciparum D6 No
Acacia nilotica Fabaceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 13 µg/ml IC50 Plasmodium falciparum D10 Nd
[23] Sudan Seeds Methanol Very Good 0.9–4.1 µg/ml IC50 Plasmodium falciparum 3D7, Dd2 No
Acacia polyacantha Fabaceae [20] Tanzania Root Barkss Ethyl Acetate Moderate 13 µg/ml IC50 Plasmodium falciparum K1 Nd
Acacia tortilis Fabaceae [24] Kenya Stem Barks Methanol Moderate 13.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[22] South Africa Whole Plant Dichloromethane/Methanol Very Good 4.8 µg/ml IC50 Plasmodium falciparum D10 Nd
Acacia xanthoploea Fabaceae [25] South Africa Stem Barks Acetone Moderate 10.1 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) Nd
[24] Kenya Stem Barks Methanol Moderate 17.3 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Acacia mellifera Fabaceae [24] Kenya Stem Barks Methanol Moderate 12.3 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Amorpha fruticosa Euphorbiaceae [26] Kenya Leaves Methanol Moderate 13.8 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Acampe pachyglossa Orchidaceae [20] Kenya Leaves Ethyl Acetate Moderate 11 µg/ml IC50 Plasmodium falciparum K1 Nd
Acanthospermum hispidum DC Compositae [27] Burkina Faso Stems, Leaves Crude Alkaloid Good 4–10 µg/ml IC50 Plasmodium falciparum W2 Nd
[28] Ivory Coast Stems and Leaves Ethanol Moderate 13.7 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain Nd
[29] Republic of Congo Leaves Methanolic, Ethanol Very Good 2.8 µg/ml IC50 Plasmodium falciparum No
Achyranthes aspera Amaranthaceae [22] South Africa Whole plant Dichloromethane/Methanol Good 9.9 µg/ml IC50 Plasmodium falciparum D10 Nd
Acmella caulirhiza Compositae [30] Kenya Whole plant Dichloromethane Good 5.201–9.939 µg/ml IC50 Plasmodium falciparum W2, D6 Nd
Acridocarpus chloropterus Malpighiaceae [31] Tanzania Roots Dichloromethane Good 5.06 µg/ml IC50 Plasmodium falciparum K1 No
Achyranthes aspera Amaranthaceae [20] Tanzania Root barks Ethyl Acetate Very Good 3 µg/ml IC50 Plasmodium falciparum K1 Nd
Adansonia digitata Malvaceae [20] Kenya Stem barks Ethyl Acetate Good 8.2 µg/ml IC50 Plasmodium falciparum K1 Nd
Adenia cissampeloides Passifloraceae [32] Ghana Whole plant Ethanol Good 8.521 µg/ml IC50 Plasmodium falciparum 3D7 Nd
Adhatoda latibracteata Acanthaceae [33] Gabon Stems Dichloromethane Very Good 0.7–1.6 µg/ml IC50 Plasmodium falciparum Fcbm W2 No
Aerva javanica Amaranthaceae [34] Sudan Whole plant Petroleum Ether/Chloroform Very Good  < 5 µg/ml IC50 Plasmodium falciparum Nd
Aerva lanata Amaranthaceae [20] Tanzania Whole plant Ethyl Acetate Good 8.6 µg/ml IC50 Plasmodium falciparum K1 Nd
Aframomum giganteum Zingiberaceae [33] Gabon Stems Dichloromethane Moderate 8.3–13.5 µg/ml IC50 Plasmodium falciparum Fcbm W2 No
Agathosma apiculata Rutaceae [22] South Africa Whole plant Dichloromethane/Methanol Good 5.2 µg/ml IC50 Plasmodium falciparum D10 Nd
Ageratum conyzoides Compositae [24] Kenya Whole plant Methanol Moderate 11.5–12.1 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[30] Kenya Whole plant Dichloromethane Very Good 2.15–3.444 µg/ml IC50 Plasmodium falciparum W2, D6 Nd
Ajuga remota Lamiaceae [35] Kenya Ns Ns Gooda 8.2 µM IC50 Plasmodium falciparum FCA 20/GHA No
[35] Kenya Aerial parts Chloroform Good 8.2 µg/ml IC50 Plasmodium falciparum FCA 20/GHA No
Alafia barteri Apocynaceae [36] Nigeria Leaves Water Very Good 1.5 µg/ml IC50 Plasmodium falciparum Nd
Albizia coriaria Fabaceae [30] Kenya Stem barks Dichloromethane Good 6.798–10.679 µg/ml IC50 Plasmodium falciparum W2, D6 Nd
[24] Kenya Stem barks Methanol Moderate 15.2–16.8 µg/ml C50 Plasmodium falciparum D6, W2 Nd
Albizia gummifera Fabaceae [24] Kenya Stem barks Methanol Good 6.7 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[20] Tanzania Stem barks Ethyl Acetate Moderate 15 µg/ml IC50 Plasmodium falciparum K1 Nd
Albizia versicolor Welw.ex Oliv Fabaceae [37] South Africa Roots Dichloromethane Very Good 2.12 µg/ml IC50 Plasmodium falciparum NF54 Nd
Alchornea cordifolia Euphorbiaceae [38] Ivory Coast Leaves Ethanol Very Gooda 0.2–0.5 μM IC50 Plasmodium falciparum Fcm29 Cameroon And Nigerian Strain No
[39] Ivory Coast Stems, leaves Water, Ethanol, Pentane Very Good 2.43–4.56 µg/ml IC50 Plasmodium falciparum Fcm29, Fcb1, Plasmodium falciparum CQ-S (Nigerian) No
[40] D.R.Congo Leaves Water Very Good 4.84 µg/ml IC50 Plasmodium falciparum K1 No
Alepidea amatymbica Apiaceae [22] South Africa Whole plant Dichloromethane/Methanol Moderate 12.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Aloe marlothii Xanthorrhoeaceae [22] South Africa Whole plant Dichloromethane Very Good 3.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Aloe ferox Xanthorrhoeaceae [22] South Africa Whole plant Dichloromethane/Methanol Good 8 µg/ml IC50 Plasmodium falciparum D10 Nd
Aloe maculata Xanthorrhoeaceae [22] South Africa Whole plant Dichloromethane/Methanol Moderate 12.4 µg/ml IC50 Plasmodium falciparum D10 Nd
Aloe pulcherrima Xanthorrhoeaceae [41] Ethiopia Roots N-Hexane, Chloroform, Acetone Ans Methanol Moderatea 18.6 µg/ml IC50 Plasmodiumfalciparum Nd
Aloe secundiflora Xanthorrhoeaceae [24] Kenya Leaves Methanol Moderate 15.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Alstonia boonei Apocynaceae [42] Nigeria Stem barks Ethanol Nd nd Plasmodium beghei NK-65 No
[43] Ivory Coast Stem barks Ethanol Moderate 12.3 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Alstonia congensis Apocynaceae [44] D.R. Congo Leaves, Root Barks, Stem Barks Water, Methanol Very Good 2—5 µg/ml IC50 Plasmodium falciparum K1 Nd
Ampelocissus africana Vitaceae [20] Kenya Whole plant Ethyl Acetate Good 9.0 µg/ml IC50 Plasmodium falciparum K1 Nd
Andrographis peniculata Acanthaceae [45] Cambodia Whole plant Dichloromethane Moderate 12.7 µg/ml IC50 Plasmodium falciparum W2 Nd
Annickia kummeriae Annonaceae [31] Tanzania Leaves Methanol Very Good 0.12 µg/ml IC50 Plasmodium falciparum K1 No
Anisopappus chinensis Compositae [46] D.R. Congo Whole plant Methanolic and dichloromethane Good 6.53 µg/ml IC50 Plasmodium falciparum (3D7, W2), Plasmodium berghei berghei No
Annona reticulata Annonaceae [47] Cameroon Roots Ethanol Very good 1.90 µg/ml IC50 Plasmodium falciparum W2 No
Annona muricata Annonaceae [48] Ivory Coast Leaves Pentane Moderate 8–18 µg/ml IC50 Plasmodium falciparum FCM29, Plasmodium falciparum CQ-S (Nigerian) Nd
[49] Cameroon Leaves Hexane Very Good 2.03 µg/ml IC50 Plasmodium falciparum W2 Nd
[47] Cameroon Stem barks Ethanol Very Good 1.45 µg/ml IC50 Plasmodium falciparum W2 No
Anogeissus leiocarpus Combretaceae [50] Nigeria Ns Methanol, Water, Butanol, Ethyl Acetate Moderate 10.94–13.77 µg/ml IC50 Plasmodium falciparum 3D7, K1 Yes (SI = 121; mouse [NBMH])
[51] Ivory Coast Leaves Methylene Chloride Very Good 3.8 µg/ml IC50 Plasmodium falciparum K1 No
Anonidium mannii Annonaceae [49] Cameroon Twigs Methanol Very Good 2.04 µg/ml IC50 Plasmodium falciparum W2 Nd
Ansellia africana Orchidaceae [20] Tanzania Leaves Ethyl Acetate Moderate 10 µg/ml IC50 Plasmodium falciparum K1 Nd
Anthocleista grandiflora Gilg Gentianaceae [37] South Africa Stem barks Dichloromethane Good 8.69 µg/ml IC50 Plasmodium falciparum NF54 Nd
Anthocleista nobilis Gentianaceae [52] Burkina Faso Leaves Dichloromethane Moderate 10 µg/ml Plasmodium falciparum Nd
Anthocleista vogelii Gentianaceae [53] Nigeria Roots Petroleum Ether Good 9.50 µg/ml IC50 Plasmodium falciparum D10 Nd
Arenga engleri Arecaceae [25] South Africa Stem barks Dichloromethane Very Good 1.7 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) Yes (ID50 = 35 µg/ml; Monkey kidney cells)
Artabotrys monteiroae Annonaceae [22] South Africa Twigs Dichloromethane/Methanol Good 8.7 µg/ml IC50 Plasmodium falciparum D10 Nd
Artemisia afra Asteraceae [54] Zimbabwe Leaves Petrolether/Ethylacetate Moderate 8.9–15.3 µg/ml IC50 Plasmodium falciparum Pow, Dd2 Nd
[22] South Africa Leaves Dichloromethane Good 5 µg/ml IC50 Plasmodium falciparum D10 Nd
[24] Kenya Leaves Methanol Good 3.9–9.1 µg/ml C50 Plasmodium falciparum D6, W2 Nd
Artemisia annua L Asteraceae [24] Kenya Leaves Methanol Good 4.7–5.5 µg/ml C50 Plasmodium falciparum D6, W2 Nd
Artocarpus communis Moraceae [55] Cameroon Stems, Leaves Ethanol, Water, Dichloromethane, Methanol, Hexane Very Good 0.67–8.20 µg/ml IC50 Plasmodium falciparum W2 Nd
Asparagus virgatus Asparagaceae [22] South Africa Whole plant Dichloromethane/Methanol Good 8 µg/ml IC50 Plasmodium falciparum D10 Nd
Aspilia africana Asteraceae [56] Uganda Shoots Ethyl Acetate Moderate 9.3–11.5 µg/ml IC50 Plasmodium falciparum D10, K1 Nd
Aspilia pruliseta Compositae [24] Kenya Root BARKS Methanol Good 6.8–9.7 µg/ml C50 Plasmodium falciparum D6, W2 Nd
Asystasia gangetica Acanthaceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 16 µg/ml IC50 Plasmodium falciparum D10 Nd
Azadirachta indica Meliaceae [57] Ivory Coast Stems, leaves Water Very Good 2.35–6.8 µg/ml IC50 Plasmodium falciparum Fcb1 & F32 Nd
[45] Cambodia Barks Dichloromethane Very Good 4.7 µg/ml IC50 Plasmodium falciparum W2 Nd
[58] Sudan Leaves Methanol Very Good 1.7–5.8 µg/ml IC50 Plasmodium falciparum 3D7, Dd5 Nd
[59] Togo Leaves Ethanol Very Good 2.48–2.5 µg/ml IC50 Plasmodium falciparum W2, D6 Nd
Azanza garckeana Malvaceae [60] Malawi Leaves Dichloromethane Moderate 11·79 µg/ml IC50 Plasmodium falciparum, Vl/S Nd
Balanites aegyptiaca Zygophyllaceae [24] Kenya Root barks Methanol Good 8.9 µg/ml C50 Plasmodium falciparum D6, W2 Nd
[21] Kenya Root barks Methanol Very good 3.49 µg/ml IC50 Plasmodium falciparum D6 No
Balanites maughamii Zygophyllaceae [25] South Africa Stem barks Dichloromethane Very good 1.94 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) Nd
Barringtonia racemosa Lecythidaceae [22] South Africa Twigs Dichloromethane/Methanol Good 5.7 µg/ml IC50 Plasmodium falciparum D10 Nd
Berberis holstii Berberidaceae [61] Malawi Roots Dichloromethane/Methanol Very good 0.17 µg/ml IC50 Plasmodium falciparum 3D7 Nd
[24] Kenya Root barks Methanol Very Good  < 5 µg/ml C50 Plasmodium falciparum D6, W2 Nd
Bergia suffruticosa Elatinaceae [62] Burkina Faso Whole plant Dichloromethane Moderate 19.53 µg/ml IC50 Plasmodium falciparum 3D7 & W2 Nd
Berula erecta Apiaceae [22] South Africa Whole plant Dichloromethane/Methanol Good 6.6 µg/ml IC50 Plasmodium falciparum D10 Nd
[24] Kenya Leaves Methanol Good 9.9 µg/ml C50 Plasmodium falciparum D6, W2 Nd
[22] South Africa Leaves Methanol Good 5 µg/ml IC50 Plasmodium falciparum D10 Nd
Bidens engleri Compositae [63] Senegal Leaves Petroleum ether Moderate 9–18 µg/ml IC50 Plasmodium falciparum FcM29, FcB1, Plasmodium vinckei petteri Yes (IC50 = 10 µg/ml; Vero cells)
Bixa orellana Bixaceae [45] Cambodia Leaves Water Good 9.3 µg/ml IC50 Plasmodium falciparum W2 Nd
Boscia angustifolia Capparaceae [24] Kenya Stem barks Water Very good 1.4–4.7 µg/ml C50 Plasmodium falciparum D6, W2 Nd
Boscia salicifolia Capparaceae [26] Kenya Stem barks Methanol good 1.1–8.8 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Boswellia dalzielii Burseraceae [50] Nigeria Ns Methanol, Water, Butanol, Ethyl Acetate Moderate 14.59–15.1 µg/ml IC50 Plasmodium falciparum 3D7, K1 Yes (SI ≥ 101; Mouse [NBMH]
[62] Burkina Faso Leaves Methanol Moderate 18.85 µg/ml IC50 Plasmodium falciparum 3D7 & W2 Nd
Bridelia micrantha Phyllanthaceae [26] Kenya Stem Barks Methanol Moderate 14.2–19.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Bridelia mollis Hutch Phyllanthaceae [37] South Africa Roots Dichloromethane Very good 3.06 µg/ml IC50 Plasmodium falciparumNF54 Nd
Brucea javanica Simaroubaceae [45] Cambodia Roots Dichloromethane Very good 1.0 µg/ml IC50 Plasmodium falciparum W2 Nd
Bruguiera gymnorhiza Rhizophoraceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 11.7 µg/ml IC50 Plasmodium falciparum D10 Nd
Burchellia bubalina Rubiaceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 18 µg/ml IC50 Plasmodium falciparum D10 Nd
Caesalpinia bonducella Fabaceae [64] Nigeria Aerial Parts Ethyl Acetate Moderate 16 µg/ml EC50 Plasmodium falciparum Yes (SI = 0.29–0.69; mouse mammary tumour [FM3A])
Canthium setosum Rubiaceae [65] Benin Aerial Parts Methylene Chloride Very good 2.77–4.80 µg/ml IC50 Plasmodium falciparum 3D7 & K1 Nd
Capparis tomentosa Lam Capparaceae [37] South Africa Roots Dichloromethane Very good 2.19 µg/ml IC50 Plasmodium falciparum NF54 Nd
Cardiospermum halicacabum Sapindaceae [22] South Africa Whole Plant Dichloromethane/Methanol Moderate 20 µg/ml IC50 Plasmodium falciparum D10 Nd
Carica papaya Caricaceae [66] Nigeria Leaves Ethyl Acetate Very good 2.96 µg/ml IC50 Plasmodium falciparum D10, DD2 No
Carissa edulis Apocynaceae [21] Kenya Root barks Methanol Good 6.41 µg/ml IC50 Plasmodium falciparum D6 No
Carpolobia alba Polygalaceae [53] Nigeria Roots Dichloromethane Good 7.10 µg/ml IC50 Plasmodium falciparum D10 Nd
Cassia abbreviata Fabaceae [60] Malawi Roots Dichloromethane Very Good 2·88 µg/ml IC50 Plasmodium falciparum Vl/S Nd
Cassia alata Fabaceae [67] D.R.Congo Leaves Ethanol, Methanol, Petroleum Ether, Chloroform Very Good  < 0.1—5.4 µg/ml IC50 Plasmodium Falciparum Nd
Senna occidentalis L Fabaceae [68] Mozambique And Portugal Roots N-Hexane Moderate 19.3 µg/ml IC50 Plasmodium falciparum 3D7 Nd
[26] Kenya Root Barks Methanol Moderate 18.8 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[69] D.R. Congo Leaves Petroleum Ether Very Good 1.5 µg/ml IC50 Plasmodium falciparum Nd
[67] D.R. Congo Leaves Ethanol, Methanol, Petroleum Ether, Chloroform Very Good  < 0.1—0.25 µg/ml IC50 Plasmodium falciparum Nd
Cassia siamea Fabaceae [70] Togo Leaves Water Good  < 7 µg/ml IC50 Plasmodium falciparum Nd
[27] Burkina Faso Leaves Crude Alkaloid Good 4–10 µg/ml IC50 Plasmodium falciparum W2 Nd
Cassia tora Fabaceae [23] Sudan Aerial parts Methanol Good 3.3–5.2 µg/ml IC50 Plasmodium falciparum 3D7, Dd2 No
Catha edulis Celastraceae [22] South Africa Roots Dichloromethane Very Good 0.68 µg/ml IC50 Plasmodium falciparum D10 Nd
Cedrelopsis grevei Rutaceae [71] Madagascar Leaves Water Moderate 17.5 mg/L IC50 Plasmodium falciparum Nd
Celtis integrifolia Cannabaceae [52] Burkina Faso Leaves Dichloromethane Very Good 3.7 µg/ml IC50 Plasmodiumfalciparum Yes (SI ≥ 0.5; HepG2 cells)
Centella asiatica Apiaceae [22] South Africa Leaves Dichloromethane/Methanol Good 8.3 µg/ml IC50 Plasmodium falciparum D10 Nd
[72] Kenya Root Barks Dichloromethane Moderate 14.9–15.4 µg/ml IC50 Plasmodium falciparum K1, NF54 Nd
Cephalanthus natalensis Rubiaceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 16.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Ceratotheca sesamoides Pedaliaceae [63] Senegal Leaves Petroleum ether Moderate 15–23 µg/ml IC50 Plasmodium falciparum FcM29, FcB1, Plasmodium vinckei petteri Yes (IC50 = 50 µg/ml; Vero cells)
Chrysophyllum perpulchrum Sapotaceae [43] Ivory Coast Stem Barks Ethanol Moderate 12.8 µg/ml IC50 Plasmodium falciparumFCB1 Nd
Cinchona succirubra Rubiaceae [73] S. Tome´ And Prı ´Ncipe Barks Petroleum Ether, Dichloromethane, Ethyl Acetate, Methanol Good  < 10 µg/ml IC50 Plasmodium falciparum3D7 And Dd2 Nd
Cinnamonum camphora Lauraceae [57] Ivory Coast Cortex Water Moderate 9.37–16.6 µg/ml IC50 Plasmodium falciparumFcb1 & F32 Nd
Cissampelos mucronata Menispermaceae [20] Tanzania Roots Ethyl Acetate Very Good 0.38 µg/ml IC50 Plasmodium falciparumK1 Nd
[26] Kenya Leaves Methanol Very Good 4.4 µg/ml IC50 Plasmodium falciparumD6, W2 Nd
Cissampelos pareira Menispermaceae [24] Kenya Root Barks Methanol Good 5.2–6.5 µg/ml C50 Plasmodium falciparumD6, W2 Nd
[74] Kenya Root Methanol Good 5.85–7.70 µg/ml IC50 Plasmodium falciparumNF54, ENT30 Nd
Cissus populnea Vitaceae [50] Nigeria Ns Methanol, Water, Butanol, Ethyl Acetate Moderate 15.81–19.91 µg/ml IC50 Plasmodium falciparum3D7, K1 Yes (SI ≥ 84, Mouse [NBMH])
Citropsis articulata Rutaceae [75] Uganda Root Barks Ethyl Acetate Nd nd Plasmodium falciparumFcb1 Nd
Clausena anisota Rutaceae [24] Kenya Stem Barks Methanol Good 8.4–9.2 µg/ml C50 Plasmodium falciparumD6, W2 Nd
[22] South Africa Twigs Dichloromethane/Methanol Moderate 18 µg/ml IC50 Plasmodium falciparumD10 Nd
Clematis brachiata Thunb Ranunculaceae [37] South Africa Roots Dichloromethane Good 5.36 µg/ml IC50 Plasmodium falciparumNF54 Nd
[21] Kenya Root Barks Methanol Very Good 4.15 µg/ml IC50 Plasmodium falciparumD6 No
Clerodendrum eriophyllum Lamiaceae [72] Kenya Root Barks Dichloromethane Very Good 2.7–5.3 µg/ml IC50 Plasmodium falciparumK1, NF54 Nd
[24] Kenya Leaves Methanol Very Good  < 1.8–3.9 µg/ml C50 Plasmodium falciparumD6, W2 Nd
Clerodendrum glabrum E. Mey Lamiaceae [37] South Africa Leaves Dicloromethane Good 8.89 µg/ml IC50 Plasmodium falciparumNF54 Nd
Clerodendrum glabrum var. glabrum Lamiaceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 19 µg/ml IC50 Plasmodium falciparumD10 Nd
Clerodendrum johnstonii Lamiaceae [24] Kenya Root Barks Methanol Good 8.5 µg/ml C50 Plasmodium falciparumD6, W2 Nd
Rotheca myricoides Lamiaceae [76] Kenya Root Barks Methanol Good 4.0—8.4 µg/ml IC50 Plasmodium falciparum(K39, ENT30, NF54, V1/S) Nd
[26] Kenya Root Barks Methanol Good 4.7–8.3 µg/ml IC50 Plasmodium falciparumD6, W2 Nd
[20] Tanzania Root Barks Ethyl Acetate Moderate 11 µg/ml IC50 Plasmodium falciparumK1 Nd
[72] Kenya Root Barks Dichloromethane Moderate 10.9–15.8 µg/ml IC50 Plasmodium falciparumK1, NF54 Nd
Clerodendrum rotundifolium Lamiaceae [24] Kenya Leaves Dichloromethane Good  < 3.9–15.7 µg/ml C50 Plasmodium falciparumD6, W2 Nd
[77] Uganda Leaves Ethyl Acetate Very Good 0.03–0.21 µg/ml IC50 Plasmodium falciparumNF54 & FCR3 Nd
Clutia abyssinica Peraceae [24] Kenya Leaves Methanol Moderate 7.8–11.3 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Clutia hirsuta Peraceae [22] South Africa Whole Plant Dichloromethane/Methanol Moderate 15 µg/ml IC50 Plasmodium falciparum D10 Nd
Clutia robusta Peraceae [24] Kenya Leaves Methanol Good 3.4–7.5 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Cochlospermum planchonii Bixaceae [78] Burkina Faso Rhizomes Methanol, Dichloromethane Gooda 2.4–11.5 μg/ml IC50 Plasmodium falciparum 3D7 Nd
[51] Ivory Coast Roots Methylene Chloride Very Good 4.4 µg/ml IC50 Plasmodium falciparum K1 No
Cochlospermum tinctorium Bixaceae [79] Burkina Faso Tubecles Ns Very Good 1–2 µg/ml IC50 Plasmodium falciparum Nd
[79] Burkina Faso Tubercles Water Very Good 0.4–1.56 µg/ml IC50 Plasmodium falciparum Fcbl And F32 Nd
Cola caricaefolia Malvaceae [48] Ivory Coast Leaves Pentane Moderate 11–16 µg/ml IC50 Plasmodium falciparum FCM29, CQ-S (Nigerian) No
Combretum collinum Combretaceae [52] Burkina Faso Leaves Dichloromethane Very Good 0.2 µg/ml IC50 Plasmodiumfalciparum Nd
Combretum micranthum Combretaceae [57] Ivory Coast Stem, Leaves Water Very Good 0.88–1.7 µg/ml IC50 Plasmodium falciparum Fcb1 & F32 Nd
Combretum psidioides subsp. Psilophyllum Combretaceae [20] Tanzania Root Barks Ethyl Acetate Good 6.5 µg/ml IC50 Plasmodium falciparum K1 Nd
Combretum zeyheri Combretaceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 15 µg/ml IC50 Plasmodium falciparum D10 Nd
Commiphora africana Burseraceae [24] Kenya Stem Barks Methanol Good 9.6–10.2 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Commiphora schimperi Burseraceae [26] Kenya Stem Barks Methanol Very Good 3.9–5.2 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[21] Kenya Inner Barks Methanol Very Good 4.63 µg/ml IC50 Plasmodium falciparum D6 No
Conyza albida Asteraceae [22] South Africa Whole Plant Dichloromethane/Methanol Very Good 2 µg/ml IC50 Plasmodium falciparum D10 Nd
Conyza podocephala Asteraceae [22] South Africa Whole Plant Dichloromethane/Methanol Good 6.8 µg/ml IC50 Plasmodium falciparum D10 Nd
Conyza scabrida Asteraceae [22] South Africa Flower Dichloromethane/Methanol Good 7.8 µg/ml IC50 Plasmodium falciparum D10 Nd
Copaifera religiosa Fabaceae [33] Gabon Leaves Dichloromethane Moderate 8.5–13.4 µg/ml IC50 Plasmodium falciparum FCB, 3D7 Yes (CC50 = 4.87 µg/ml; human embryonic lung cells [MRC-5])
Cordia myxa Boraginaceae [52] Burkina Faso Leaves Dichloromethane Good 6.2 µg/ml IC50 Plasmodiumfalciparum Yes (SI = 0.5–0.9; HrpG2 cells)
Coula edulis Olacaceae [80] Cameroon Stem Barks Methanol Good 5.79–13.8 µg/ml IC50 Plasmodium falciparum 3D7, DD2 No
Crossopteryx febrifuga Rubiaceae [27] Burkina Faso Leaves Crude Alkaloid Good 4–10 µg/ml IC50 Plasmodium falciparum W2 Nd
Crotalaria burkeana Fabaceae [22] South Africa Roots Dichloromethane Good 9.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Croton gratissimus var. subgratissimus Euphorbiaceae [22] South Africa Leaves Dichloromethane Very Good 3.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Croton lobatus Euphorbiaceae [65] Benin Roots Methanol Good 2.80–6.56 µg/ml IC50 Plasmodium falciparum 3D7 & K1 Nd
Croton macrostachyus Euphorbiaceae [30] Kenya Leaves, Stems Dichloromethane Very Good 2.72 µg/ml IC50 Plasmodium falciparum W2, D6 Nd
Croton menghartii Euphorbiaceae [22] South Africa Leaves Dichloromethane/Methanol Very Good 1.7 µg/ml IC50 Plasmodium falciparum D10 Nd
Croton pseudopulchellus Euphorbiaceae [25] South Africa Stem Barks Chloroform Very Good 3.45 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) Nd
Croton zambesicus Euphorbiaceae [55] Cameroon Stem Barks Ethanol, Water, Dichloromethane, Methanol, Hexane Good 0.88–9.14 µg/ml IC50 Plasmodium falciparum W2 Nd
[34] Sudan Fruits Petroleum Ether/Chloroform Very Good  < 5 µg/ml IC50 Plasmodium falciparum Nd
Cryptolepis sanguinolenta Apocynaceae [81] Guinea-Bissau Leaves, Roots Ethanol, Chcl3, Chloroform Very Good 1.79 µg/ml IC50 Plasmodium falciparum K1, T996 Nd
[82] Ghana Roots Ethanol Very gooda 0.031 µg/ml IC50 Plasmodium falciparum K1, Plasmodium berghei Nd
[83] D.R. Congo Root barks Water, ethanol, chloroform Very good 27–41 ng/ml IC50 Plasmodium falciparum D6, K1, W2, Plasmodium berghei yoelii, Plasmodium berghei berghei Nd
[84] Ghana Roots Hexane, ethanol, dichloromethane Very gooda 0.2–0.6 μM IC50 Plasmodium vinckei petteri, Plasmodium berghei ANKA Nd
Cussonia spicata Thunb Araliaceae [22] South Africa Fruits Dichloromethane/Methanol Moderate 14 µg/ml IC50 Plasmodium falciparum D10 Nd
[37] South Africa Root Barks Dichloromethane Very Good 3.25 µg/ml IC50 Plasmodium falciparum NF54 Nd
Cussonia zimmermannii Araliaceae [20] Tanzania Root Barks Petroleum Ether Very Good 3.3 µg/ml IC50 Plasmodium falciparum K1 Nd
Cuviera longiflora Rubiaceae [80] Cameroon Leaves Dichloromethane/Methanol Moderate 13.91–20.24 µg/ml IC50 Plasmodium falciparum 3D7, DD2 No
Cyathala prostate Amaranthaceae [43] Ivory Coast Whole Plant Ethanol Moderate 12.4 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Cyathula schimperiana Amaranthaceae [24] Kenya Root Barks Methanol Moderate 5–17.6 µg/ml C50 Plasmodium falciparum D6, W2 Nd
Cymbopogon validus Poaceae [22] South Africa Whole Plant Dichloromethane/Methanol Good 5.8 µg/ml IC50 Plasmodium falciparum D10 Nd
Cyperus articulatus Cyperaceae [24] Kenya Tubers Methanol Good 4.8–8.7 µg/ml C50 Plasmodium falciparum D6, W2 Nd
[74] Kenya Rhizomes Methanol Good 4.84–8.68 µg/ml IC50 Plasmodium falciparum NF54, ENT30 Nd
Cyphostemma spp Vitaceae [86] Namibia Whole Plant Methanol Very Good 3.276 µg/ml IC50 Plasmodium falciparum 3D7 Nd
Dacryodes edulis Burseraceae [80] Cameroon Leaves Dichloromethane/Methanol Good 6.45–8.62 µg/ml IC50 Plasmodium falciparum 3D7, DD2 No
[85] Cameroon Root Barks Methylene Chloride/Methanol Very Good 0.37 µg/ml IC50 Plasmodiumfalciparum No
Dichapetalum guineense Dichapetalaceae [65] Benin Leaves Methanol Moderate 7.35- > 20 µg/ml IC50 Plasmodium falciparum 3D7 & K1 Nd
Dichrostachys cinerea Wight et Arn Fabaceae [37] South Africa Roots Dichloromethane Very Good 2.1 µg/ml IC50 Plasmodium falciparum NF54 Nd
Dicoma tomentosa Asteraceae [62] Burkina Faso Whole Plant Dichloromethane, Methanol Good 7.04–7.90 µg/ml IC50 Plasmodium falciparum 3D7 & W2 Nd
[87] Burkina Faso Whole plant Dichloromethane Very Good 1.9–3.4 µg/ml IC50 Plasmodium Falcipârum 3D7, W2, Plasmodium berghei Nd
Diospyros abysinica Ebenaceae [75] Uganda Leaves Ethyl Acetate Nd nd Plasmodium falciparum Fcb2 Nd
Diospyros mespiliformis Ebeneceae [86] Namibia Leaves, Roots Methanol Very Good 3.179–3.523 µg/ml IC50 Plasmodium falciparum 3D7 Nd
[37] South Africa Roots Dichloromethane Very Good 4.40 µg/ml IC50 Plasmodium falciparum NF54 Nd
Diospyros monbuttensis Ebenaceae [88] Nigeria Leaves Methanol Very Good 3.2 nM Plasmodium falciparum Nd
Dombeya shupangae Malvaceae [20] Tanzania Root Barks Ethyl Acetate Good 7.5 µg/ml IC50 Plasmodium falciparum K1 Nd
Dorstenia convexa Moraceae [56] Cameroon Twigs Ethanol, Water, Dichloromethane, Methanol, Hexane Good 0.28–8.95 µg/ml IC50 Plasmodium falciparum W2 Nd
Dorstenia klaineana Moraceae [33] Gabon Stems Methanol Moderate 16.7–17.0 µg/ml IC50 Plasmodium falciparum Fcbm, W2 Yes (SI = 16.2–28.89; human embryonic lung cells [MRC-5])
Dracaena cambodiana Asparagaceae [45] Cambodia Stems Dichloromethane Good 8.7 µg/ml IC50 Plasmodium falciparum W2 Nd
Drypetes natalensis Putranjivaceae [31] Tanzania Roots Ethanol Very Good 1.06 µg/ml IC50 Plasmodium falciparum K1 No
Ekebergia capensis Meliaceae [22] South Africa Fruits Dichloromethane/Methanol Moderate 10 µg/ml IC50 Plasmodium falciparum D10 Nd
[76] Kenya Stem Barks Chloroform Good 3.9—13.4 µg/ml IC50 Plasmodium falciparum K39, ENT30, NF54, V1/S Nd
[21] Kenya Inner Barks Methanol Very Good 3.97 µg/ml IC50 Plasmodium falciparum D6 No
[24] Kenya Stem Barks Methanol Moderate 10.5 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Elaeis guineensis Arecaceae [32] Ghana Leaves Ethanol Very Good 1.195 µg/ml IC50 Plasmodium falciparum 3D7 Nd
Elaeodendron buchananii Celastraceae [24] Kenya Stem Barks Methanol Moderate 17.1 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Enantia chlorantha Annonaceae [55] Cameroon Stem Barks Ethanol, Water, Dichloromethane, Methanol, Hexane Good 0.68–14.72 µg/ml IC50 Plasmodium falciparum W2 Nd
[40] DR Congo Stem Barks Water Good 7.77 µg/ml IC50 Plasmodium falciparum K1 Yes (CC50 = 3.0 µg/ml; human embryonic lung cells [MRC-5])
Entandrophragma angolense Meliaceae [89] Cameroon Stem Barks Dichloromethane/Methanol Moderate 18.4 µg/ml IC50 Plasmodium falciparum W2 Nd
Entandrophragma caudatum Meliaceae [25] South Africa Stem Barks Dichloromethane Very Good 2.9 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) No
Entandrophragma palustre Meliaceae [46] D.R. Congo Stem barks Methanol Moderate 15.84 µg/ml IC50 Plasmodium falciparum 3D7, W2, Plasmodium berghei berghei Nd
Erigeron floribundus Asteraceae [48] Ivory Coast Leaves Pentane Good 4.3-10 µg/ml IC50 Plasmodium falciparum FCM29, Plasmodium falciparum CQ-S (Nigerian) Nd
Erioglossum edule Sapindaceae [45] Cambodia Barks Dichloromethane Very Good 1.7 µg/ml IC50 Plasmodium falciparum W2 Nd
Erythrina abyssinica Fabaceae [75] Uganda Barks Ethyl Acetate Nd nd Plasmodium falciparum Fcb3 Nd
Erythrina lysistemon Fabaceae [25] South Africa Stem Barks Acetone Very Good 4.8 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) Nd
Erythrina sacleuxii Fabaceae [20] Tanzania Root Barks Ethyl Acetate Very Good 3.0 µg/ml IC50 Plasmodium falciparum K1 Nd
Erythrococca anomala Euphorbiaceae [43] Ivory Coast Leaves Ethanol Moderate 13.1 µg/dl IC50 Plasmodium falciparum FCB1 Nd
Euclea divinorum Ebenaceae [24] Kenya Root Barks Methanol Good 6.9–12.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Euclea natalensis Ebenaceae [22] South Africa Twigs Dichloromethane/Methanol Very Good 4.6 µg/ml IC50 Plasmodium falciparum D10 Nd
Eucomis autumnalis Asparagaceae [22] South Africa Bulbs Dichloromethane/Methanol Good 9.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Euphorbia hirta Euphorbiaceae [90] D.R. Congo Aerial Parts Methanol, Hexane: Ethyl Acetate Gooda 1.1—5.4 µg/ml IC50 Plasmodium falciparum No
[70] D.R. Congo Whole Plant Petroleum Ether Very Good 1.2 µg/ml IC50 Plasmodium falciparum Nd
Euphorbia tirucalli Euphorbiaceae [22] South Africa Leaves Dichloromethane Moderate 12 µg/ml IC50 Plasmodium falciparum D10 Nd
Fadogia agrestis Rubiaceae [27] Burkina Faso Leaves Crude Alkaloid Good 4–10 µg/ml IC50 Plasmodium falciparum W2 Nd
Fagara macrophylla Rutaceae [28] Ivory Coast Stem Barks Ethanol Very Good 2.3 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain No
Fagaropsis angolensis Rutaceae [24] Kenya Stem Barks Methanol Good 4.2–6.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Fagraea fragrans Gentianaceae [45] Cambodia Stems Dichloromethane Moderate 12.8 µg/ml IC50 Plasmodium falciparum W2 Nd
Ficus capraefolia Moraceae [52] Burkina Faso Leaves Dichloromethane Very Good 1.8 µg/ml IC50 Plasmodium falciparum Yes (SI = 0.4; HepG2 cells)
Ficus platyhylla Moraceae [50] Nigeria Ns Methanol, Water, Butanol, Ethyl Acetate Moderate 13.77–15.28 µg/ml IC50 Plasmodium falciparum 3D7, K1 Yes (SI ≥ 77; mouse [NBMH])
Ficus sur Moraceae [24] Kenya Stem Barks Methanol Moderate 8.5–15.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[76] Kenya Stem Barks Chloroform, Hexane Moderate 9.0–19.2 µg/ml IC50 Plasmodium falciparum K39 (CQ-S), ENT30, NF54, V1/S Nd
Ficus thonningii Moraceae [29] Republic Of Congo Leaves Methanol, Ethanol Good 9.61 µg/ml IC50 Plasmodium falciparum No
[50] Nigeria Ns Methanol, Water, Butanol, Ethyl Acetate Moderate 14.09–25.06 µg/ml IC50 Plasmodium falciparum 3D7, K1 Yes (SI ≥ 103; mouse [NBMH])
Ficus sycomorus Moraceae [27] Burkina Faso Leaves Crude Alkaloid Good 4–10 µg/ml IC50 Plasmodium falciparum W2 Nd
Flueggea virosa Phyllanthaceae [91] Comoros Leaves Water/Methanol Very Good 2 µg/ml IC50 Plasmodium falciparum W2 No
[26] Kenya Stem Barks Methanol Very Good 2.2–3.6 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[22] South Africa Leaves, Twigs Water Moderate 11.4 µg/ml IC50 Plasmodium falciparum D10 Nd
Fuerstia africana Lamiaceae [92] Rwanda Leaves, Stems Methanol Good 4.1–6.9 µg/ml IC50 Plasmodium falciparum 3D7, W2 Yes (SI = 1.9; human normal foetal lung fibroblast [WI-38)
[21] Kenya Leaves Methanol Very Good 3.76 µg/ml IC50 Plasmodium falciparum D6 No
[24] Kenya Whole Plant Methanol Very Good 0.9–2.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Funtumia elastica Apocynaceae [43] Ivory Coast Stem Barks Ethanol Very Good 3.6 µg/ml IC50 Plasmodium falciparum FCB1 Nd
[28] Ivory Coast Stem Barks Ethanol Very Good 3.3 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain No
Funtumia latifolia Apocynaceae [75] Uganda Leaves Ethyl Acetate Nd nd Plasmodium falciparum Fcb4 Nd
Garcinia kola Clusiaceae [67] D.R. Congo Seeds Ethanol, Methanol, Petroleum Ether, Chloroform Good 1.02—15.75 µg/ml IC50 Plasmodium falciparum Nd
[69] D.R. Congo Stem Barks Petroleum Ether Very Good 1.6 µg/ml IC50 Plasmodium falciparum Nd
Gardenia lutea Rubiaceae [23] Sudan Leaves Methanol Good 3.3–5.2 µg/ml IC50 Plasmodium falciparum 3D7, Dd2 No
Gardenia sokotensis Rubiaceae [62] Burkina Faso Leaves Dichloromethane Moderate 14.01 µg/ml IC50 Plasmodium falciparum 3D7 & W2 Nd
Glinus oppositifolius Molluginaceae [93] Mali Aerial parts Chloroform Moderate 15.52–18.70 µg/ml IC50 Plasmodium falciparum W2 & 3D7 No
Gloriosa superba Colchicaceae [22] South Africa Whole plant Dichloromethane/Methanol Moderate 17 µg/ml IC50 Plasmodium falciparum D10 Nd
Gnidia cuneata Thymelaeaceae [22] South Africa Stems Dichloromethane Moderate 15.9 µg/ml IC50 Plasmodium falciparum D10 Nd
Gnidia kraussiana var. kraussiana Thymelaeaceae [22] South Africa Leaves, Twigs Dichloromethane/Methanol Moderate 10.8 µg/ml IC50 Plasmodium falciparum D10 Nd
Gomphrena celosioides Amaranthaceae [65] Benin Aerial Parts Methanol Good 4.26–14.97 µg/ml IC50 Plasmodium falciparum 3D7 & K1 Nd
[70] Togo Aerial Parts Water Moderate  < 15 µg/ml IC50 Plasmodium falciparum Nd
[20] Tanzania Whole plant Ethyl Acetate Moderate 15 µg/ml IC50 Plasmodium falciparum K1 Nd
Guiera senegalensis Combretaceae [57] Ivory Coast Stem, Leave Water Good 0.79–7.03 µg/ml IC50 Plasmodium falciparum Fcb1 & F32 Nd
[94] Mali Roots Chloroform Very Gooda  < 4 µg/ml IC50 Plasmodium falciparum Nd
Gutenbergia cordifolia Asteraceae [21] Kenya Leaves Methanol Very Good 4.40 µg/ml IC50 Plasmodium falciparum D6 No
Gynandropsis gynandra Cleomaceae [20] Tanzania Roots Ethyl Acetate Moderate 14 µg/ml IC50 Plasmodium falciparum K1 Nd
H. suaveolens Lamiaceae [53] Nigeria Leaves Petroleum Ether Very Good 2.54 µg/ml IC50 Plasmodium falciparum D10 Nd
Haplophyllum tuberculatum Rutaceae [23] Sudan Aerial Parts Methanol Very Good 1.2–1.5 µg/ml IC50 Plasmodium falciparum 3D7, Dd2 No
Harrisonia abyssinica Rutaceae [58] Sudan Stem Barks Methanol Good 4.7–10 µg/ml IC50 Plasmodium falciparum 3D7, Dd3 Nd
[72] Kenya Stem Barks Dichloromethane Good 4.4–5.6 µg/ml IC50 Plasmodium falciparum K1, NF54 Nd
[26] Kenya Root Barks Methanol Good 7.8–11.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[95] Kenya Barks/Roots/Stem Water Very Good 1.0 µg/ml IC50 Plasmodium Knowlesi Nd
Harrisonia perforata Rutaceae [45] Cambodia StemS Dichloromethane Good 6.0 µg/ml IC50 Plasmodium falciparum W2 Nd
Harungana madagascariensis Hypericaceae [40] D.R.Congo Stem Barks Water Good 9.64 µg/ml IC50 Plasmodium falciparum K1 No
[20] Tanzania Roots Ethyl Acetate Very Good 4.0 µg/ml IC50 Plasmodium falciparum K1 Nd
Helichrysum gymnocephalum Asteraceae [96] Madagascar Leaves Essential Oil In Active 25 mg/l Plasmodium falciparum Fcb1 Nd
Helichrysum cymosum Asteraceae [97] South Africa Leaves Water, Essential Oil Very Gooda 1.25 µg/ml IC50 Plasmodium falciparum FCR-3 Yes
Helichrysum nudifolium Asteraceae [22] South Africa Whole plant Dichloromethane/Methanol Good 6.8 µg/ml IC50 Plasmodium falciparum D10 Nd
Hermannia depressa Malvaceae [22] South Africa Whole plant Dichloromethane/Methanol Good 6.9 µg/ml IC50 Plasmodium falciparum D10 Nd
Hexalobus crispiflorus Annonaceae [98] Cameroon Stem Barks Water Very Gooda 2.0 µg/ml IC50 Plasmodium falciparum W6 Nd
Hippobromus pauciflorus Sapindaceae [22] South Africa Twigs Dichloromethane/Methanol Good 5.9 µg/ml IC50 Plasmodium falciparum D10 Nd
Holarrhena floribunda Apocynaceae [99] Cameroon Stem Barkss Water, Ethanol Good 1.02 − 18.53 μg/mL IC50 Plasmodium falciparum W2,D6, FCR-3, 3D7 Nd
Hoslundia opposita Lamiaceae [20] Tanzania Root Barks Petroleum Ether Moderate 10 µg/ml IC50 Plasmodium falciparum K1 Nd
[26] Kenya Leaves Methanol Moderate 15.2–25.6 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[75] Uganda Leaves Ethyl Acetate Nd nd Plasmodium falciparum Fcb5 Nd
Hunteria eburnea Apocynaceae [43] Ivory Coast Stem Barks Ethanol Very Good 2.2 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Hybanthus enneaspermus Violaceae [65] Benin Aerial Parts Methanol Moderate 2.57- > 20 µg/ml IC50 Plasmodium falciparum 3D7 & K1 Nd
Hymenocardia acida Phyllanthaceae [51] Ivory Coast Leaves Methylene Chloride Good 6.9 µg/ml IC50 Plasmodium falciparum K1 Yes (SI = 6–10; rat skeletal muscle myoblast [L6])
Hypericum aethiopicum Hypericaceae [22] South Africa Leaves/Flowers Dichloromethane/Methanol Very Good 1.4 µg/ml IC50 Plasmodium falciparum D10 Nd
Hypericum lanceolatum Hypericaceae [80] Cameroon Stem Barks Methanol, N-Hexane, Ethyl Acetate, N-Butanol Very Good 3.98 µg/ml IC50 Plasmodium falciparum W2, SHF4 Nd
Hypoestes forskaolii Acanthaceae [24] Kenya Root Barks Methanol Good 4.3–6.7 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Hyptis pectinata Lamiaceae [22] South Africa Leaves, Stem, Flower Dichloromethane/Methanol Moderate 17.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Icacina senegalensis Icacinaceae [100] Senegal Leaves Methanol Good 4.7–8 µg/ml IC50 Plasmodium falciparum 3D7, 7G8 No
Isolona hexaloba Annonaceae [40] D.R. Congo Root Barks Water Moderate 15.28 µg/ml IC50 Plasmodium falciparum K1 No
Khaya grandifoliola Meliaceae [101] Cameroon Barks, Seeds Methanol-Methylene Chloride Gooda 1.25—9.63 μg/ml IC50 Plasmodium falciparum W2 Nd
Khaya senegalensis Meliaceae [50] Nigeria Ns Methanol, Water, Butanol, Ethyl Acetate Moderate 15.46–28.12 µg/ml IC50 Plasmodium falciparum 3D7, K1 Yes (SI ≥ 69; mouse [NBMH])
Kigelia africana Bignoniaceae [24] Kenya Leaves Methanol Moderate 15.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[80] Cameroon Stem Barks Ethyl Acetate Moderate 11.15 μg/mL IC50 Plasmodium falciparum W2 No
Kirkia wilmsii Kirkiaceae [22] South Africa Leaves Dichloromethane/Methanol Very Good 3.7 µg/ml IC50 Plasmodium falciparum D10 Nd
Kniphofia foliosa Xanthorrhoeaceae [102] Ethiopia Roots Dichloromethane Very Good 3.8 µg/mL ED50 Plasmodium falciparum 3D7 No
Landolphia lanceolata Apocynaceae [103] Congo Brazzaville Roots Dichloromethane Moderate 11 µg/ml IC50 Plasmodium falciparum Fcm29-Cameroon Nd
Lannea edulis Anacardiaceae [20] Kenya Whole Plant Ethyl Acetate Moderate 17 µg/ml IC50 Plasmodium falciparum K1 Nd
Lantana camara Verbenaceae [22] South Africa Leaves, Twigs Dichloromethane/Methanol Moderate 11 µg/ml IC50 Plasmodium falciparum D10 Nd
Leonotis mollissima Lamiaceae [20] Tanzania Leaves Ethyl Acetate Good 9 µg/ml IC50 Plasmodium falciparum K1 Nd
Leonotis africana Lamiaceae [33] Gabon Stems Dichloromethane Moderate 15.2–27.1 µg/ml IC50 Plasmodium falciparum Fcbm W2 Yes (SI = 6.07–6.82; human embryonic lung cells [MRC-5])
Leonotis leonurus Lamiaceae [22] South Africa Leaves, Twigs Dichloromethane/Methanol Good 5.4 µg/ml IC50 Plasmodium falciparum D10 Nd
Leonotis nepetifolia Lamiaceae [22] South Africa Whole Plant Dichloromethane/Methanol Moderate 15 µg/ml IC50 Plasmodium falciparum D10 Nd
Leonotis ocymifolia Lamiaceae [22] South Africa Leaves Dichloromethane/Methanol Good 6.1 µg/ml IC50 Plasmodium falciparum D10 Nd
Leptadenia madagascariensis Apocynaceae [91] Comoros Ns Dichloromethane Good 9 µg/ml IC50 Plasmodium falciparum W2 No
Leucas calostachys Lamiaceae [95] Kenya Whole Plant Water Very Good 0.79 µg/ml IC50 Plasmodium Knowlesi Nd
Leucas martinicensis Lamiaceae [22] South Africa Whole Plant Dichloromethane/Methanol Moderate 13.3 µg/ml IC50 Plasmodium falciparum D10 Nd
Lippia javanica Verbenaceae [24] Kenya Root Barks Methanol Good 5.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[104] Kenya Roots Dichloromethane/Ethyl Acetate Moderate 16.7—19.2 µg/ml IC50 Plasmodium falciparum K39, V1/S Nd
[22] South Africa Roots Dichloromethane Very Good 3.8 µg/ml IC50 Plasmodium falciparum D10 Nd
[25] South Africa Leaves Acetone Very Good 4.26 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) Nd
Lippia multiflora Verbenaceae [57] Ivory Coast Leaves Water Very Good 1.18—2.34 µg/ml IC50 Plasmodium falciparum Fcb1 & F32 Nd
Lophira lanceolata Ochnaceae [52] Burkina Faso Leaves Dichloromethane Very Good 4.7 µg/ml IC50 Plasmodium falciparum Nd
Ludwigia erecta Onagraceae [24] Kenya Whole plant Methanol Very Good 0.9–1.6 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Macrostylis squarrosa Rutaceae [22] South Africa Stems Dichloromethane/Methanol Moderate 16 µg/ml IC50 Plasmodium falciparum D10 Nd
Maesa lanceolata Primulaceae [22] South Africa Twigs Dichloromethane/Methanol Good 5.9 µg/ml IC50 Plasmodium falciparum D10 Nd
Markhamia lutea Bignognaceae [76] Uganda Leaves Ethyl Acetate Nd Nd Plasmodium falciparum Fcb6 Nd
Maytenus heterophylla Celastraceae [24] Kenya Root barks Methanol Very Good 1.8–3.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Maytenus obtusifolia Celastraceae [24] Kenya Root barks Methanol Good  < 1.9–5.8 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Maytenus putterlickioides Celastraceae [26] Kenya Root Barks Methanol Good 4.4–10.2 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Maytenus senegalensis Celastraceae [58] Sudan Stem barks Methanol Nd 3.9–10 µg/ml IC50 Plasmodium falciparum 3D7, Dd9 Nd
[26] Kenya Root barks Methanol Good 4.7–9.8 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[22] South Africa Roots Dichloromethane Moderate 15.5 µg/ml IC50 Plasmodium falciparum D10 Nd
[20] Tanzania Stem barks Ethyl Acetate Very Good 0.16 µg/ml IC50 Plasmodium falciparum K1 Nd
[31] Tanzania Roots Ethanol Very Good 2.05 µg/ml IC50 Plasmodium falciparum K1 No
Maytenus undata Celastraceae [26] Kenya Leaves Water Very Good 0.95–1.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Melia azedarach Meliaceae [46] D.R. Congo Leaves Dichloromethane Moderate 19.14 µg/ml IC50 Plasmodium falciparum 3D7, W2, Plasmodium berghei berghei Nd
Microdesmis keayana Pandaceae [51] Ivory Coast Leaves Methylene Chloride Moderate 12.2 µg/ml IC50 Plasmodium falciparum K1 No
Microglossa pyrifolia Asteraceae [24] Kenya Leaves Methanol Moderate 10.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[77] Uganda Leaves Ethyl Acetate Very Good 0.03–0.05 µg/ml IC50 Plasmodium falciparum NF54 & FCR3 Nd
[92] Rwanda Leaves Dichloromethane Very Good 1.5–2.4 µg/ml IC50 Plasmodium falciparum 3D7, W2 Yes (SI = 3.2; human normal foetal lungfibroblast [WI-38])
Mikania cordata Compositae [20] Tanzania Leaves Ethyl Acetate Moderate 14 µg/ml IC50 Plasmodium falciparum K1 Nd
Millettia zechiana Fabaceae [28] Ivory Coast Stem Barks Ethanol Moderate 16.1 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain Nd
[43] Ivory Coast Stem Barks Ethanol Moderate 14.1 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Momordica balsamina Cucurbitaceae [22] South Africa Stems Dichloromethane/Methanol Good 5.3 µg/ml IC50 Plasmodium falciparum D10 Nd
[68] Mozambique Aerial Parts Ns Very Gooda 1 μM Plasmodium berghei, Plasmodium falciparum Nd
Momordica charantia Cucurbitaceae [88] Nigeria Leaves Methanol Very Good 12.5 nM Plasmodium falciparum Nd
Momordica foetida Cucurbitaceae [77] Uganda Leaves Water Good 0.35–6.16 µg/ml IC50 Plasmodium falciparum NF54 & FCR3 Nd
Monodora myristica Annonaceae [33] Gabon Stem Methanol Good 5.5–6.1 µg/ml IC50 Plasmodium falciparum Fcbm W2 No
[49] Cameroon Leaves Methanol Good 9.03 µg/ml IC50 Plasmodium falciparum W2 Nd
Morinda lucida Rubiaceae [74] S. Tome´ And Prı ´Ncipe Barks Ethanol Good  < 10 µg/ml IC50 Plasmodium falciparum 3D7 and Dd2 Nd
[88] Nigeria Leaves Methanol Very Good 25 nM Plasmodium falciparum Nd
[53] Nigeria Roots Dichloromethane Moderate 13.37 µg/ml IC50 Plasmodium falciparum D10 Nd
Morinda morindoides Rubiaceae [43] Ivory Coast Leaves Ethanol Good 9.8 µg/ml IC50 Plasmodium falciparum FCB1 Nd
[28] Ivory Coast Leaves Ethanol Moderate 11.6 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain Nd
Moringa oleifera Moringaceae [26] Kenya Leaves Methanol Moderate 9.8 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Motandra guineensis Apocynaceae [43] Ivory Coast Leaves Ethanol Moderate 16.3 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Mundulea sericea Fabaceae [86] Namibia Leaves, Shoots Methanol Very Good 3.279–3.352 µg/ml IC50 Plasmodium falciparum 3D7 Nd
Mitragyna inermis Rubiaceae [93] Mali Leaves Chloroform Very Good 4.36–4.82 µg/ml IC50 Plasmodium falciparum W2 & 3D7 No
Nauclea latifolia Rubiaceae [93] Mali Barks Chloroform Good 5.36–6.2 µg/ml IC50 Plasmodium falciparum W2 & 3D7 Yes (IC50 = 50 µg/ml; BALB/C mouse)
[28] Ivory Coast Barks Ethanol Good 8.9 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain No
[106] Ivory Coast Roots, Stem Water Good 0.6–7.5 µg/ml IC50 Plasmodium falciparum Fcb1- Colombian And Nigerian Strains Nd
[43] Ivory Coast Root Barks Ethanol Good 7.3 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Nauclea pobeguinii Rubiaceae [107] D.R.Congo Stem Barks Ethanol In Active 32 µg/ml IC50 Plasmodium falciparum, Plasmodium yeolii, Plasmodium berghei No
Neoboutonia glabrescens Euphorbiaceae [55] Cameroon Leaves Ethanol, Water, Dichloromethane, Methanol, Hexane Good 7.56 µg/ml IC50 Plasmodium falciparum W2 Nd
Neorautanenia mitis Fabaceae [31] Tanzania Tubers Ethanol Very Good 1.58 µg/ml IC50 Plasmodium falciparum K1 No
Newbouldia laevis Bignognaceae [108] Togo Leaves Ethanol Moderate 12.6 µg/ml IC50 Plasmodium falciparum Nd
[109] Nigeria Leaves Water Moderate 19.5 µg/ml IC50 Plasmodium falciparum Nd
[53] Nigeria Roots Dichloromethane Good 5.00 µg/ml IC50 Plasmodium falciparum D10 Nd
Ocimum americana Lamiaceae [24] Kenya Whole Plant Methanol Moderate 8.9–12.1 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[22] South Africa Whole Plant Dichloromethane/Methanol Very Good 4.2 µg/ml IC50 Plasmodium falciparum D10 Nd
Ocimum basilicum Lamiaceae [159] D.R. Congo Leaves Ethanol, Methanol, Petroleum Ether, Chloroform Good  < 0.35–18 µg/ml IC50 Plasmodium falciparum Nd
[26] Kenya Leaves Methanol Moderate 16.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Ocimum gratissimum Lamiaceae [30] Kenya Leaves, Twigs Dichloromethane Good 8.616 µg/ml IC50 Plasmodium falciparum W2, D6 Nd
[40] DR Congo Leaves Water Good 7.25 µg/ml IC50 Plasmodium falciparum K1 No
[26] Kenya Leaves Methanol Good 5.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Ocimum kilimandscharicum Lamiaceae [30] Kenya Leaves, Twigs Dichloromethane Very Good 0.843–1.547 µg/ml IC50 Plasmodium falciparum W2, D6 Nd
Olax gambecola Olacaceae [43] Ivory Coast Whole Plant Ethanol Good 5.2 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Olea europaea Oleaceae [24] Kenya Stem Barks Methanol Moderate 17.3 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[21] Kenya Inner Barks Methanol Good 9.48 µg/ml IC50 Plasmodium falciparum D6 No
[22] South Africa Leaves Dichloromethane/Methanol Moderate 12 µg/ml IC50 Plasmodium falciparum D10 Nd
Opilia celtidifolia Opiliaceae [52] Burkina Faso Leaves Dichloromethane Very Good 2.8 µg/ml IC50 Plasmodium falciparum Yes (SI = 0.4; HepG2 cells)
Ormocarpum trachycarpum Fabaceae [77] Kenya Stem Barks Dichloromethane/Ethyl Acetate Moderate 17.5—19.6 µg/ml IC50 Plasmodium falciparum K39, V1/S Nd
Osteospermum imbricatum Asteraceae [22] South Africa Stems Dichloromethane/Methanol Good 7.3 µg/ml IC50 Plasmodium falciparum D10 Nd
Phyllanthus amarus Phyllanthaceae [53] Nigeria Leaves Petroleum Ether Very Good 4.99 µg/ml IC50 Plasmodium falciparum D10 Nd
Pachypodanthium confine Annonaceae [98] Cameroon Stem Barks Water Moderatea 16.6 µg/ml IC50 Plasmodium falciparum W3 Nd
Pappea capensis Eckl.& Zeyh Sapindaceae [37] South Africa Twigs Dichloromethane Good 5.47 µg/ml IC50 Plasmodium falciparum NF54 Nd
Parinari curatellifolia Chrysobalanaceae [22] South Africa Roots Dichloromethane Good 5.3 µg/ml IC50 Plasmodium falciparum D10 Nd
[24] Kenya Root Barks Methanol Good 3.9–7.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[37] South Africa Stem Barks Dichloromethane Good 6.99 µg/ml IC50 Plasmodium falciparum NF54 Nd
Parinari excelsa Chrysobalanaceae [20] Tanzania Stem Barks Ethyl Acetate Moderate 10 µg/ml IC50 Plasmodium falciparum K1 Nd
[75] Uganda Barks Ethyl Acetate Nd Nd Plasmodium falciparum Fcb7 Nd
Parkinsonia aculeata Fabaceae [22] South Africa Twigs Dichloromethane/Methanol Good 9 µg/ml IC50 Plasmodium falciparum D10 Nd
Pavetta corymbosa Rubiaceae [65] Benin Aerial parts Methanol Moderate 5.54–20 µg/ml IC50 Plasmodium falciparum 3D7 & K1 Nd
[110] Togo Aerial parts Methanol Very Good 2.042 µg/ml IC50 Plasmodium falciparum Nd
[110] Togo Aerial part Methanol Very Good 2.042 µg/ml IC50 Plasmodium falciparum Nd
Pavetta crassipes Rubiaceae [27] Burkina Faso Leaves Crude Alkaloid Very Good  < 4 µg/ml IC50 Plasmodium falciparum W2 Nd
[71] Togo Aerial parts Water Good  < 7 µg/ml IC50 Plasmodium falciparum Nd
Pelargonium alchemilloides Geraniaceae [22] South Africa Whole plant Dichloromethane/Methanol Moderate 15 µg/ml IC50 Plasmodium falciparum D10 Nd
Pentas lanceolata Rubiaceae [21] Kenya Root barks Methanol Good 5.15 µg/ml IC50 Plasmodium falciparum D6 No
Pentas longiflora Rubiaceae [26] Kenya Root barks Methanol Moderate 13.3 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Pentzia globosa Asteraceae [22] South Africa Roots Dichloromethane Good 8 µg/ml IC50 Plasmodium falciparum D10 Nd
Phyllanthus amarus Phyllanthaceae [111] Ghana Whole Plant Ethanol Moderate 11.7 µg/ml IC50 Plasmodium falciparum Dd2 No
Phyllanthus fraternus Phyllanthaceae [112] Ghana Whole plant Methanol Very Good 0.44 µg/ml IC50 Plasmodium falciparum 3D7, W2 No
Phyllanthus muellerianus Phyllanthaceae [28] Ivory Coast Leaves Ethanol Good 9.4 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain No
[43] Ivory Coast Leaves Ethanol Moderate 10.3 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Phyllanthus niruri Phyllanthaceae [69] D.R.Congo Whole Plant Petroleum Ether Very Good 1.3 µg/ml IC50 Plasmodium falciparum Nd
Phyllanthus urinaria Phyllanthaceae [45] Cambodia Whole Plant Water Very Good 2.4 µg/ml IC50 Plasmodium falciparum W2 Nd
Physalis angulata Solanaceae [28] Ivory Coast Whole Plant Ethanol Good 7.9 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain Nd
[43] Ivory Coast Whole Plant Ethanol Good 7.9 µg/ml IC50 Plasmodium falciparum FCB1 Nd
[44] D.R. Congo Leaves Methanolic and dichloromethane Very good 1.27 µg/ml IC50 Plasmodium falciparum 3D7, W2, Plasmodium berghei berghei No
Picralima nitida Apocynaceae [53] Nigeria Roots Ethanol Good 6.29 µg/ml IC50 Plasmodium falciparum D10 Nd
[113] Nigeria Stems Methanol Good 6.0–6.3 µg/ml IC50 Plasmodium falciparum D6, W2 No
[89] Cameroon Seeds Methanol Moderate 10.9 µg/ml IC50 Plasmodium falciparum W2 Nd
[114] Ivory Coast Root, Stem Barks Ans Fruit Rins Ns Very Good 0.188–1.581 μg/ml IC50 Plasmodium falciparum Nd
Piper capense Piperaceae [91] Comoros Ns Dichloromethane Good 7 µg/ml IC50 Plasmodium falciparum W2 No
Piptadeniastrum africanum Leguminosae [40] D.R. Congo Stem Barks Water Good 6.11 µg/ml IC50 Plasmodium falciparum K1 Yes (SI = 1.4–1.5; human embryonic lung cells [MRC-5])
[40] D.R.Congo Stem Barks Water Good 6.11 µg/ml IC50 Plasmodium falciparum K1 No
Piptostigma calophyllum Annonaceae [49] Cameroon Leaves Methanol Good 6.72 µg/ml IC50 Plasmodium falciparum W2 Nd
Pittosporum viridiflorum Pittosporaceae [24] Kenya Leaves Methanol Moderate 17.6–18.9 µg/ml iC50 Plasmodium falciparum D6, W2 Nd
[22] South Africa Whole Plant Dichloromethane Very Good 3 µg/ml IC50 Plasmodium falciparum D10 Nd
Plumbago zeylanica Plumbaginaceae [22] South Africa Leaves Dichloromethane Very Good 3 µg/ml IC50 Plasmodium falciparum D10 Nd
Podocarpus latifolius Podocarpaceae [21] Kenya Root Barks Methanol Good 6.43 µg/ml IC50 Plasmodium falciparum D6 No
Pollichia campestris Caryophyllaceae [22] South Africa Twigs Dichloromethane/Methanol Good 6.8 µg/ml IC50 Plasmodium falciparum D10 Nd
Polyalthia longifolia Annonaceae [115] Ghana Stem Barks Ethanol, N-Hexane,Dichloromethane, Ethyl Acetate, Methanol-Ethyl Acetate Gooda 3–6 µg/ml IC50 Plasmodium falciparum K1 No
[116] Ghana Stem Barks Methanol, Chloroform, Cyclohexane, Ethyl Acetate Gooda 4.53–10.17 µM IC50 Plasmodium falciparum 3D8 Nd
Polyalthia oliveri Annonaceae [55] Cameroon Stem Barks Ethanol, Water, Dichloromethane, Methanol, Hexane Very Good 4.30 µg/ml IC50 Plasmodium falciparum W2 Nd
[49] Cameroon Stem Barks Methanol Very Good 3.43 µg/ml IC50 Plasmodium falciparum W2 Nd
Polyalthia suaveolens Annonaceae [49] Cameroon Twigs Methanol Very Good 3.23 µg/ml IC50 Plasmodium falciparum W2 Nd
Polygonatum verticillatum Asparagaceae [117] Kenya Rhizome N-Hexane, Chloroform Very Good 2.33—4.62 μg/ml IC50 Plasmodium
falciparum
No
Premna chrysoclada Lamiaceae [26] Kenya Leaves Methanol Moderate 11.1 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Prosopis africana Fabaceae [50] Nigeria Ns Methanol, Water, Butanol, Ethyl Acetate Moderate 14.97–15.28 µg/ml IC50 Plasmodium falciparum 3D7, K1 Yes (SI ≥ 99; mouse heart-derived cells [NBMH])
Prunus africana Rosaceae [24] Kenya Stem Barks Methanol Moderate 17.3 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Pseudospondias microcarpa Anacardiaceae [31] Tanzania Roots Ethanol Very Good 1.13 µg/ml IC50 Plasmodium falciparum K1 No
Psiadia punctulata Asteraceae [22] South Africa Twigs Dichloromethane Good 9 µg/ml IC50 Plasmodium falciparum D10 Nd
Psidium guajava Myrtaceae [40] DR Congo Leaves Water Good 5.46 µg/ml IC50 Plasmodium falciparum K1 No
[20] Tanzania Leaves Ethyl Acetate Moderate 10 µg/ml IC50 Plasmodium falciparum K1 Nd
Psorospermum senegalense Hypericaceae [63] Burkina Faso Leaves Dichloromethane Moderate 10.03 µg/ml IC50 Plasmodium falciparum 3D7 & W2 No
Ptaeroxylon obliquum Rutaceae [22] South Africa Stems Dichloromethane/Methanol Good 5.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Pterocarpus angolensis Fabaceae [22] South Africa Roots Dichloromethane Moderate 10.6 µg/ml IC50 Plasmodium falciparum D10 Nd
Pterocarpus erinaceus Fabaceae [118] Burkina Faso Leaves Ans Barks Ethanol, Chloroform Very Good 1.93 µg/ml IC50 Plasmodium falciparum 3D7 And Dd2 Nd
Pulicaria crispa Asteraceae [34] Sudan Whole Plant Petroleum Ether/Chloroform Very Good  < 5 µg/ml IC50 Plasmodium falciparum Nd
Pycnanthus angolensis Myristicaceae [28] Ivory Coast Stem Barks Ethanol Moderate 18.2 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain Nd
[74] S. Tome´ And Prı ´Ncipe Barks Ethanol Very Good  < 5 µg/ml IC50 Plasmodium falciparum 3D7 And Dd2 Nd
Pyrenacantha grandiflora Baill Icacinaceae [37] South Africa Roots Dichloromethane Good 5.82 µg/ml IC50 Plasmodium falciparum NF54 Nd
Quassia africana Simaroubaceae [103] Congo Brazzaville Leaves Water, Ethanol, Dichloromethane Very Good 0.1–2.2 µg/ml IC50 Plasmodium falciparum Fcm29-Cameroon Yes (IC50 = 6.7 µg/ml; KB cells)
[40] D.R. Congo Root Barks Water Very Good 0.46 µg/ml IC50 Plasmodium falciparum K1 No
Ranunculus multifidus Ranunculaceae [22] South Africa Whole Plant Dichloromethane/Methanol Very Good 2.3 µg/ml IC50 Plasmodium falciparum D10 Nd
Rauvolfia caffra Sond Apocynaceae [37] South Africa Roots Dichloromethane Very Good 2.13 µg/ml IC50 Plasmodium falciparum NF54 Nd
Rauvolfia nombasiana Apocynaceae [26] Kenya Root Barks Methanol Good 9.1 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Rauvolfia vomitoria Apocynaceae [53] Nigeria Roots Dichloromethane Very Good 4.78 µg/ml IC50 Plasmodium falciparum D10 Nd
[28] Ivory Coast Barks Ethanol Very Good 2.5 µg/ml IC50 Plasmodium falciparum Fcb1/Colombia Strain No
[43] Ivory Coast Root Barks Ethanol Very Good 2.5 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Rhamnus prinoides Rhamnaceae [77] Kenya Roots Methanol Moderate 15.1 µg/ml IC50 Plasmodium falciparum K39 (CQ-S), ENT30, NF54, V1/S Nd
[21] Kenya Root Barks Methanol Very Good 3.53 µg/ml IC50 Plasmodium falciparum D6 No
Rhizophora mucronata Rhizophoraceae [22] South Africa Twigs Dichloromethane/Methanol Good 5.6 µg/ml IC50 Plasmodium falciparum D10 Nd
Ricinus communis var. communis Euphorbiaceae [22] South Africa Stems Water Good 8.0 µg/ml IC50 Plasmodium falciparum D10 Nd
Rubia cordifolia Rubiaceae [95] Kenya Leaves/Seeds/Stems Methanol Very Good 1.20 µg/ml IC50 Plasmodium Knowlesi Nd
[24] Kenya Whole Plant Methanol Very Good  < 5 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Rumex abyssinicus Polygonaceae [92] Rwanda Roots Water Very Good 3.1–4.3 µg/ml IC50 Plasmodium falciparum 3D7, W2 Yes (SI = 3.1; human normal foetal lung fibroblast [WI-38])
Rumex crispus Polygonaceae [22] South Africa Roots Dichloromethane Moderate 14 µg/ml IC50 Plasmodium falciparum D10 Nd
Salacia madagascariensis Celastraceae [20] Tanzania Roots Petroleum Ether Very Good 0.8 µg/ml IC50 Plasmodium falciparum K1 Nd
Salvia africana-lutea Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Moderate 15.863 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
Salvia albicaulis Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Moderate 15.833 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
Salvia aurita Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Good 8.923 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
Salvia chamelaeagnea Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Good 8.713 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
Salvia dolomitica Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Good 7.623 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
Salvia garipensis Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Moderate 13.953 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
Salvia muirii Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Moderate 11.873 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
Salvia radula Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Very Good 3.913 µg/ml IC50 Plasmodium falciparum FCR-3 Yes (IC50 = 20.12 µg/ml; Kidney cells)
Salvia repens Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Good 8.253 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
[22] South Africa Whole Plant Dichloromethane/Methanol Moderate 10.8 µg/ml IC50 Plasmodium falciparum D10 Nd
Salvia runcinata Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Moderate 16.613 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
Salvia schlechteri Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Moderate 17.513 µg/ml IC50 Plasmodium falciparum FCR-3 Nd
Salvia stenophylla Lamiaceae [120] South Africa Aerial Parts Methanol/Chloroform Good 6.53 µg/ml IC50 Plasmodium falciparum FCR-3 Yes (IC50 = 12.12 µg/ml; Kidney cells)
Sonchus schweinfurthi Compositae [95] Kenya Barks/Roots Methanol Very Good 2.10 µg/ml IC50 Plasmodium Knowlesi Nd
Scaevola plumieri Goodeniaceae [22] South Africa Twigs Dichloromethane Moderate 11 µg/ml IC50 Plasmodium falciparum D10 Nd
Schefflera umbellifera Araliaceae [22] South Africa Leaves Dichloromethane/Methanol Very Good 3.7 µg/ml IC50 Plasmodium falciparum D10 Nd
Schizozygia coffaeoides Apocynaceae [26] Kenya Leaves Methanol Moderate 10.5 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Schkuhria pinnata Compositae [24] Kenya Whole Plant Methanol Good 1.3–6.8 µg/ml IC50 Plasmodium falciparumD6, W2 Nd
Schrankia leptocarpa Fabaceae [65] Benin Aerial Parts Methanol Moderate 3.38- > 20 µg/ml IC50 Plasmodium falciparum 3D7 & K1 Nd
Sclerocarya birrea Anacardiaceae [24] Kenya Stem Barks Methanol Moderate 5.9–24.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Secamone afzelii Apocynaceae [65] Benin Aerial Parts Methanol Moderate 6.48- > 20 µg/ml IC50 Plasmodium falciparum 3D7 & K1 Nd
Securidaca longipedunculata Polygalaceae [121] Mali Leaves Dichloromethane Good 6.9 µg/ml IC50 Plasmodium falciparum 3D7 Nd
Securinega virosa Phyllanthaceae [52] Burkina Faso Leaves Dichloromethane Good 7.1 µg/ml IC50 Plasmodium falciparum Nd
Senecio oxyriifolius Asteraceae [22] South Africa Whole plant Dichloromethane/Methanol Moderate 13 µg/ml IC50 Plasmodium falciparum D10 Nd
Senecio stuhlmannii Asteraceae [56] Uganda Shoots Ethyl Acetate Moderate 14.0–15.2 µg/ml IC50 Plasmodium falciparum D10, K1 Nd
Senna didymobotrya Fabaceae [22] South Africa Twigs Dichloromethane/Methanol Good 9.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Senna petersiana Fabaceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 13 µg/ml IC50 Plasmodium falciparum D10 Nd
[59] Malawi Leaves Methanol Very Good 2·67 µg/ml IC50 Plasmodium falciparum Vl/S Nd
Sericocomopsis hildebrandtii Amaranthaceae [21] Kenya Root Barks Methanol Very Good 3.78 µg/ml IC50 Plasmodium falciparum D6 No
Setaria megaphylla Poaceae [22] South Africa Whole plant Dichloromethane/Methanol Very Good 4.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Sida acuta Malvaceae [118] Burkina Faso Whole Plant Ethanol, Chloroform, Water Very Good 0.87–0.92 µg/ml IC50 Plasmodium falciparum 3D7 And Dd2 Nd
[38] Ivory Coast Ns Ethanol Good 3.9–5.4 µg/ml IC50 Plasmodium falciparum No
Solanum panduriforme Solanaceae [25] South Africa Leaves Acetone Very Good 3.62 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) Nd
Solanecio mannii Asteraceae [92] Rwanda Leaves Dichloromethane Moderate 12.7–18.2 µg/ml IC50 Plasmodium falciparum 3D7, W2 No
Spilanthes mauritiana Asteraceae [22] South Africa Stems Dichloromethane/Methanol Good 5.3 µg/ml IC50 Plasmodium falciparum D10 Nd
Staudtia gabonensis Myristicaceae [33] Gabon Stems Methanol Very Good 0.8 µg/ml IC50 Plasmodium falciparum Fcbm W2 No
Stephania abyssinica Menispermaceae [24] Kenya Root Barks Methanol Good 4.7–6.1 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Stephania rotunda Menispermaceae [45] Cambodia Tubers Dichloromethane Very Good 1.0 µg/ml IC50 Plasmodium falciparum W2 Nd
Struchium sparganophorum Asteraceae [73] S. Tome´ And Prı ´Ncipe Leaves Petroleum Ether Good  < 10 µg/ml IC50 Plasmodium falciparum 3D7 And Dd2 Nd
Strychnopsis thouarsii Menispermaceae [122] Madagascar Stem Barks Methanol Very Gooda 3.1—4.2 µM Plasmodium falciparum NF54, Plasmodium yoelli 265 BY No
Strychnos henningsii Loganiaceae [72] Kenya Twigs Methanol Moderate 14.6–17.9 µg/ml IC50 Plasmodium falciparum K1, NF54 Nd
Strychnos pungens Loganiaceae [22] South Africa Leaves Dichloromethane Moderate 12.6 µg/ml IC50 Plasmodium falciparum D10 Nd
Strychnos spinosa Loganiaceae [123] Senegal Leaves, Stem Methanol, Water Moderate 15 µg/ml IC50 Plasmodiumfalciparum Nd
Strychnos icaja Loganiaceae [46] D.R. congo Root barks Methanolic and dichloromethane Very good 0.69 µg/ml IC50 Plasmodium falciparum 3D7, W2, Plasmodium berghei berghei Nd
Suregada zanzibariensis Euphorbiaceae [26] Kenya Leaves Methanol Good 5.8–6.7 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[124] Kenya Leaves Methanol Very Good 1.82–4.66 µg/ml IC50 Plasmodium falciparum D6&W2 Nd
[124] Kenya Leaves Methanol Very Good 1.82–4.66 µg/ml IC50 Plasmodium falciparum D6, W2 No
Syzygium cordatum subsp. cordatum Myrtaceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 14.7 µg/ml IC50 Plasmodium falciparum D10 Nd
  [37] South Africa Leaves Dichloromethane Good 6.15 µg/ml IC50 Plasmodium falciparum NF54 Nd
Tabernaemontana elegans Apocynaceae [37] South Africa Roots Dichloromethane Very Good 0.33 µg/ml IC50 Plasmodium falciparum NF54 Nd
Tabernaemontana pachysiphon Apocynaceae [26] Kenya Flower Methanol Very Good 4.4–4.8 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Tagetes minuta Asteraceae [75] Uganda Leaves Ethyl Acetate Nd Nd Plasmodium falciparum Fcb8 Nd
Tamarindus indica Fabaceae [23] Sudan Stem Barks Methanol Moderate 10 µg/ml IC50 Plasmodium falciparum 3D7, Dd2 No
[110] Togo Fruits Water Very Good 4.786 µg/ml IC50 Plasmodium falciparum Nd
Tapinanthus dodoneifolius Loranthaceae [52] Burkina Faso Leaves Methanol Good 5.2 µg/ml IC50 Plasmodium falciparum Nd
Tarchonanthus camphoratus Asteraceae [22] South Africa Whole Plant Dichloromethane/Methanol Good 6 µg/ml IC50 Plasmodium falciparum D10 Nd
Teclea nobilis Rutaceae [24] Kenya Stem Barks Methanol Moderate 3.9–20.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[75] Uganda Barks Ethyl Acetate Nd Nd Plasmodium falciparum Fcb9 Nd
Tecoma capensis Bignoniaceae [22] South Africa Twigs Dichloromethane/Methanol Moderate 10.2 µg/ml IC50 Plasmodium falciparum D10 Nd
Tectona grandis Lamiaceae [112] Ghana Leaves Methanol Very Good 0.92 µg/ml IC50 Plasmodium falciparum 3D7, W2 No
Terminalia avicennioides Combretaceae [50] Nigeria Ns Methanol, Water, Butanol, Ethyl Acetate Moderate 12.28–14.09 µg/ml IC50 Plasmodium falciparum 3D7, K1 Yes (SI ≥ 114; mouse heart-derived cells [NBMH])
[52] Burkina Faso Leaves Methanol Very Good 1.9 µg/ml IC50 Plasmodium falciparum Nd
Terminalia glaucescens Combretaceae [39] Ivory Coast Stem, Leave Water, Ethanol, Pentane Very Good 2.34–4.83 µg/ml IC50 Plasmodium falciparum Fcm29, Fcb1, CQ-S (Nigerian) No
Terminalia ivorensis Combretaceae [32] Ghana Stem Barks Ethanol Good 6.949 µg/ml IC50 Plasmodium falciparum 3D7 Nd
[112] Ghana Leaves Methanol Good 5.70 µg/ml IC50 Plasmodium falciparum 3D7, W2 No
Terminalia macroptera Combretaceae [27] Burkina Faso Root Barks Water Very Good 1 µg/ml IC50 Plasmodium falciparum W2 Nd
Terminalia mollis Combretaceae [92] Rwanda Root Barks Methanol Moderate 11.7–26.3 µg/ml IC50 Plasmodium falciparum 3D7, W2 No
Terminalia spinosa Combretaceae [26] Kenya Stem Barks Methanol Good 7.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Tetracera poggei Gilg Dilleniaceae [69] DR Congo Leaves Petroleum Ether Very Good 1.7 µg/ml IC50 Plasmodium falciparum Nd
Tetrapleura tetraptera Fabaceae [33] Gabon Leaves Dichloromethane Moderate 10.1–13.0 µg/ml IC50 Plasmodium falciparum FCB, 3D7 No
Thalia geniculata Marantaceae [65] Benin Roots Methanol Moderate 2.83- > 20 µg/ml IC50 Plasmodium falciparum 3D7 & K1 Nd
Tinospora bakis Menispermaceae [34] Sudan Whole Plant Petroleum Ether/Chloroform Very Good  < 5 µg/ml IC50 Plasmodium falciparum Nd
Tithonia diversifolia Asteraceae [73] S. Tome´ And Prı ´Ncipe Aerial Parts Petroleum Ether, Dichloromethane Good  < 10 µg/ml IC50 Plasmodium falciparum 3D7 And Dd2 Nd
[92] Rwanda Flowers Dichloromethane Very Good 1.0–1.1 µg/ml IC50 Plasmodium falciparum 3D7, W2 No
Toddalia asiatica Rutaceae [26] Kenya Root Barks Methanol Good 6.82–13.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[125] Kenya Root Barks Dichloromethane + Methanol Very Gooda 9 – 100 ng/ml IC50 Plasmodium falciparum Nd
Trichilia emetica Meliaceae [121] Mali Leaves Dichloromethane Moderate 11.9 µg/ml IC50 Plasmodium falciparum 3D7 Nd
[58] Sudan Leaves Methanol Good 2.5–17.5 µg/ml IC50 Plasmodium falciparum 3D7, Dd6 Nd
[24] Kenya Stem Barks Methanol Moderate 13.3 µg/ml C50 Plasmodium falciparum D6, W2 Nd
[25] South Africa Stem Barks Acetone Very Good 3.29 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) Nd
[22] South Africa Leaves, Twigs Dichloromethane/Methanol Very Good 3.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Triclisia dictyophylla Menispermaceae [40] D.R. Congo Leaves Water Good 5.13 µg/ml IC50 Plasmodium falciparum K1 No
Tridax procumbens Asteraceae [22] South Africa Whole Plant Dichloromethane/Methanol Moderate 17 µg/ml IC50 Plasmodium falciparum D10 Nd
[26] Kenya Whole Plant Methanol Moderate 15.4 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Triumfetta welwitschii var. hirsuta Malvaceae [22] South Africa Leaves Dichloromethane/Methanol Very Good 3.6 µg/ml IC50 Plasmodium falciparum D10 Nd
Turraea floribunda Meliaceae [22] South Africa Leaves Dichloromethane/Methanol Good 8.8 µg/ml IC50 Plasmodium falciparum D10 Nd
[26] Kenya Stem Barks Methanol Good 5.5 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Turraea robusta Meliaceae [72] Kenya Root Barks Methanol Very Good 2.4–3.5 µg/ml IC50 Plasmodium falciparum K1, NF54 Nd
[24] Kenya Stem Barks Methanol Good 2.1–10.3 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Tylosema fassoglensis Fabaceae [30] Kenya Tubers Dichloromethane Very Good 0.77–0.896 µg/ml IC50 Plasmodium falciparum W2, D6 Nd
Uapaca paludosa Phyllanthaceae [103] Congo Brazzaville Barks Dichloromethane Good 8 µg/ml IC50 Plasmodium falciparum Fcm29-Cameroon Nd
Uvaria acuminata Annonaceae [26] Kenya Root Barks Methanol Good 6.9–8.9 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Uvaria scheffleri Annonaceae [26] Kenya Leaves Methanol Good 6.8 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Uvaria afzelii Annonaceae [48] Ivory Coast Roots Pentane Moderate 9–22 µg/ml IC50 Plasmodium falciparum FCM29, CQ-S (Nigerian) No
Uvariastrum zenkeri Annonaceae [49] Cameroon Twigs Ethanol Very Good 1.89 µg/ml IC50 Plasmodium falciparum W2 Nd
Uvariodendron molundense Annonaceae [49] Cameroon Twigs Methanol Very Good 4.79 µg/ml IC50 Plasmodium falciparum W2 Nd
Uvariopsis congolana Annonaceae [55] Cameroon Stems Ethanol, Water, Dichloromethane, Methanol, Hexane Very Good 4.47 µg/ml IC50 Plasmodium falciparum W2 Nd
Vangueria infausta Burch. subsp. Infausta Rubiaceae [37] South Africa Roots Dichloromethane Very Good 1.84 µg/ml IC50 Plasmodium falciparum NF54 Nd
Vepris lanceolata Rutaceae [20] Kenya Root Barks Ethyl Acetate Good 7.0 µg/ml IC50 Plasmodium falciparum K1 Nd
Vernonia amygdalina Asteraceae [74] S. Tome´ And Prı ´Ncipe Leaves Ethyl Acetate Moderate 10 µg/ml IC50 Plasmodium falciparum 3D7 And Dd2 Nd
[80] Cameroon Leaves Dichloromethane Moderate 8.72–11.27 µg/ml IC50 Plasmodium falciparum 3D7, DD2 No
[126] Nigeria Leaves Ethanol Good 9.83 µg/ml IC50 Plasmodium falciparum 3D7, NF-54 Yes (SI = 6.14; C-1008 kidney fibroblast
[26] Kenya Leaves Methanol Good 4.9–7.2 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
[127] Nigeria Leaves Ethanol Moderate 11.2 µg/ml IC50 Plasmodium falciparum Yes (LD50 = 1950 mg/kg; rat)
[69] D.R. Congo Leaves Petroleum Ether Very Good 2.5 µg/ml IC50 Plasmodium falciparum Nd
Vernonia brachycalyx Asteraceae [104] Kenya Leaves Dichloromethane/Ethyl Acetate Good 6.6—8.4 µg/ml IC50 Plasmodium falciparum K39, V1/S Nd
Vernonia cinerea Asteraceae [45] Cambodia Whole Plant Dichloromethane Moderate 18.3 µg/ml IC50 Plasmodium falciparum W2 Nd
Vernonia colorata Asteraceae [57] Ivory Coast Stems, Leaves Water Good 2.35–9.38 µg/ml IC50 Plasmodium falciparum Fcb1 & F32 Nd
[54] Zimbabwe Leaves Petrolether/Ethylacetate Moderate 12.1–17.8 µg/ml IC50 Plasmodium falciparum Pow, Dd2 Nd
[91] Comoros Roots Dichloromethane Very Good 3 µg/ml IC50 Plasmodium falciparum W2 No
[22] South Africa Leaves Dichloromethane/Methanol Very Good 4.7 µg/ml IC50 Plasmodium falciparum D10 Nd
Vernonia fastigiata Asteraceae [22] South Africa Leaves Dichloromethane/Methanol Moderate 10 µg/ml IC50 Plasmodium falciparum D10 Nd
Vernonia guineensis Asteraceae [128] Cameroon Leaves Dichloromethane Very Good 1.635—1.823 µg/ml IC50 Plasmodium falciparum No
Vernonia lasiopus Compositae [12] Kenya Leaves Chloroform, Ethylacetate, Methanol Very Good 1.0–3.2 µg/ml IC50 Plasmodium falciparum K39 (CQ-S), ENT30, NF54, V1/S Nd
[73] Kenya Root Barks Dichloromethane Very Good 4.7–4.9 µg/ml IC50 Plasmodium falciparum K1, NF54 Nd
Vernonia myriantha Asteraceae [22] South Africa Leaves Dichloromethane/Methanol Very Good 3 µg/ml IC50 Plasmodium falciparum D10 Nd
Vernonia oligocephala Asteraceae [22] South Africa Leaves Dichloromethane/Methanol Very Good 3.5 µg/ml IC50 Plasmodium falciparum D10 Nd
Vismia guineensis Hypericaceae [48] Ivory Coast Leaves Pentane Moderate 15–20 µg/ml IC50 Plasmodium falciparum FCM29, CQ-S (Nigerian) Nd
Warburgia ugandensis Canellaceae [72] Kenya Stem Barks Dichloromethane Very Good 1.4–2.2 µg/ml IC50 Plasmodium falciparum K1, NF54 Nd
[24] Kenya Root Barks Methanol Good 4.1–6.1 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Warburgia stuhlmannii Canellaceae [26] Kenya Stem Barks Methanol Very Good 1.8–2.3 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Ximenia americana Olacaceae [57] Ivory Coast Stem, Leave Water Very Good 0.6–2.6 µg/ml IC50 Plasmodium falciparum Fcb1 & F32 Nd
Xylopia aethiopica Annonaceae [98] Cameroon Stem Barks Water Moderatea 17.8 µg/ml IC50 Plasmodium falciparum W5 Nd
[49] Cameroon Leaves Methanol Very Good 3.75 µg/ml IC50 Plasmodium falciparum W2 Nd
Xylopia africana Annonaceae [49] Cameroon Stem Barks Methanol Very Good 1.07 µg/ml IC50 Plasmodium falciparum W2 Nd
Xylopia parviflora (A.Rich.)Benth.Oliv Annonaceae [37] South Africa Roots Dichloromethane Very Good 2.19 µg/ml IC50 Plasmodium falciparum NF54 Nd
[49] Cameroon Leaves Methanol Very Good 3.44 µg/ml IC50 Plasmodium falciparum W2 Nd
Xylopia phloiodora Annonaceae [98] Cameroon Stem Barks Water Moderatea 17.9 µg/ml IC50 Plasmodium falciparum W2 Nd
Xysmalobium undulatum Apocynaceae [22] South Africa Whole Plant Dichloromethane/Methanol Good 6 µg/ml IC50 Plasmodium falciparum D10 Nd
Zanthoxylum chalybeum Rutaceae [137] Kenya Root Barks Water Good 2.32–5.52 µg/ml IC50 Plasmodium falciparum NF54, ENT30 Nd
[77] Uganda Stem Barks Ethyl Acetate Very Good 0.57–3.21 µg/ml IC50 Plasmodium falciparum NF54 & FCR3 Nd
[92] Rwanda Root Barks Methanol Very Good 1.9–4.2 µg/ml IC50 Plasmodium falciparum 3D7, W2 No
[20] Tanzania Root Barks Ethyl Acetate Very Good 4.2 µg/ml IC50 Plasmodium falciparum K1 Nd
[26] Kenya Root Barks Methanol Very Good 2.9–3.7 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Zanthoxylum gilletii Rutaceae [43] Ivory Coast Stem Barks Ethanol Very Good 2.8 µg/ml IC50 Plasmodium falciparum FCB1 Nd
Zanthoxylum heitzii Rutaceae [129] Republic Of Congo Barkss Hexane Very Gooda 0.0089 µg/ml IC50 Plasmodium falciparum, Plasmodium berghei Nd
Zanthoxylum tsihanimposa Rutaceae [130] Madagascar Stem Barks Dichloromethane + Methanol Very Gooda 98.4 µM IC50 Plasmodium falciparum FCM29 Nd
Zanthoxylum usambarense Rutaceae [24] Kenya Root Barks Methanol Good 3.2–5.5 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Zea mays Poaceae [131] Nigeria Leaves Ethanol, ethyl acetate Good 3.69—9.31 µg/ml IC50 Plasmodium falciparum 3D7, INDO, Plasmodium berghei Nd
Zehreria scabra Cucurbitaceae [22] South Africa Whole Plant Dichloromethane/Methanol Good 5.6 µg/ml IC50 Plasmodium falciparum D10 Nd
[26] Kenya Whole Plant Methanol Good 9.8 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Ziziphus abyssica Rhamnaceae [24] Kenya Leaves Methanol Moderate 17.5 µg/ml IC50 Plasmodium falciparum D6, W2 Nd
Ziziphus mucronata Rhamnaceae [22] South Africa Leaves Dichloromethane Moderate 12 µg/ml IC50 Plasmodium falciparum D10 Nd
[25] South Africa Stem Barks Acetone Very Good 4.13 µg/ml IC50 Plasmodium falciparum UP1 (CQ-R) Nd
Ziziphus cambodiana Rhamnaceae [45] Cambodia Stems Dichloromethane Moderate 19.0 µg/ml IC50 Plasmodium falciparum W2 Nd
  1. Nd Not done, Ns Not specified, SI Selectivity index
  2. aActivity determined using pure compounds isolated from plant