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Table 2 Summary table of studies examining placental malaria and low birth weight infants

From: The impact of malaria during pregnancy on low birth weight in East-Africa: a topical review

Authors Country Study design (year) Sample size Treatment; frequency Method for determining malaria infection Results/comment
Kalinjuma et al. [18] Dar-es-Salaam, Tanzania Cohort study (2010–2013) 1115 SPa;
Start in 2nd trimester, then with every ANC visit
Polymerase chain reaction of parasite DNA; quantification of parasites in blood smear; histology of placental tissue PMb was not significantly associated with LBWc
Kapisi et al. [4] Tororo, Uganda Cohort study (2014) 282 SP;
Start in 2nd trimester, then given every 8th week
Quantification of parasites in blood smear; histology of placental tissue Malaria burden during pregnancy—> PM—> risk of LBW (trends, not significant)
Mohammed et al. [19] Central Sudan Case–control study (2010) 174 No information given Polymerase chain reaction of parasite DNA; quantification of parasites in blood smear; histology of placental tissue Submicroscopic malaria infection during pregnancy—> significantly higher risk of having a LBW delivery
Dong et al. [20] Tanzania Cohort study (2002–2005) 882 No information given Quantification of parasites in blood- and placental smear CXCL9d was significantly associated with LBW among malaria-infected primigravidae
  1. aSulfadoxine-pyrimethamine, bPlacental malaria, cLow birth weight, dCXC ligand 9. Note, all papers used the WHO definition of LBW (birth weight < 2.5 kg)