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Table 2 Distribution of FcγRIIa, FcγRIIIa and FcγRIIIb genotypes and alleles frequency in the different study groups

From: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

Genotypes

Malaria-free controls (n = 200)

Uncomplicated malaria (n = 218)

Severe malaria (n = 182)

FcγRIIa

 R/R (%)

36 (18.0%)

33 (15.1%)

63 (34.6%)

 H/R (%)

104 (52.0%)

105 (48.2%)

94 (51.6%)

 H/H (%)

60 (30.0%)

80 (36.7%)

25 (13.7%)

 Allele frequency

  R allele

0.44

0.40

0.61

  H allele

0.56

0.60

0.39

  HWEa

0.44

0.87

0.28

FcγRIIIa

 F/F (%)

91 (45.5%)

85 (39.0%)

132 (72.5%)

 F/V (%)

80 (40.0%)

105 (48.2%)

43 (23.6%)

 V/V (%)

29 (14.5%)

28 (12.8%)

7 (3.8%)

 Allele frequency

  F allele

0.65

0.63

0.84

  V allele

0.35

0.37

0.16

  HWEa

0.10

0.62

0.15

FcγRIIIb

 NA1/NA1 (%)

34 (17.0%)

33 (15.1%)

18 (9.9%)

 NA1/NA2 (%)

92 (46.0%)

105 (48.2%)

70 (38.5%)

 NA2/NA2 (%)

74 (37.0%)

80 (36.7%)

94 (51.6%)

 Allele frequency

  NA1 allele

0.6

0.39

0.29

  NA2 allele

0.4

0.61

0.71

  HWEa

0.56

0.88

0.36

  1. aIf < 0.05—not consistent with Hardy–Weinberg equilibrium “HWE”