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Table 2 Distribution of FcγRIIa, FcγRIIIa and FcγRIIIb genotypes and alleles frequency in the different study groups

From: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

Genotypes Malaria-free controls (n = 200) Uncomplicated malaria (n = 218) Severe malaria (n = 182)
FcγRIIa
 R/R (%) 36 (18.0%) 33 (15.1%) 63 (34.6%)
 H/R (%) 104 (52.0%) 105 (48.2%) 94 (51.6%)
 H/H (%) 60 (30.0%) 80 (36.7%) 25 (13.7%)
 Allele frequency
  R allele 0.44 0.40 0.61
  H allele 0.56 0.60 0.39
  HWEa 0.44 0.87 0.28
FcγRIIIa
 F/F (%) 91 (45.5%) 85 (39.0%) 132 (72.5%)
 F/V (%) 80 (40.0%) 105 (48.2%) 43 (23.6%)
 V/V (%) 29 (14.5%) 28 (12.8%) 7 (3.8%)
 Allele frequency
  F allele 0.65 0.63 0.84
  V allele 0.35 0.37 0.16
  HWEa 0.10 0.62 0.15
FcγRIIIb
 NA1/NA1 (%) 34 (17.0%) 33 (15.1%) 18 (9.9%)
 NA1/NA2 (%) 92 (46.0%) 105 (48.2%) 70 (38.5%)
 NA2/NA2 (%) 74 (37.0%) 80 (36.7%) 94 (51.6%)
 Allele frequency
  NA1 allele 0.6 0.39 0.29
  NA2 allele 0.4 0.61 0.71
  HWEa 0.56 0.88 0.36
  1. aIf < 0.05—not consistent with Hardy–Weinberg equilibrium “HWE”