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Table 3 Association between individual FcγRIIa, FcγRIIIa and FcγRIIIb genotypes and severity of malaria

From: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

 

UM versus MFC

SM versus UM

Adjusteda OR (95% CI)

P value

Adjustedb OR (95% CI)

P value

FcγRIIa

 R/R

1.39 (0.89–2.19)

0.15

2.132 (1.287–3.533)

0.003

 H/R

1.00

 

1.00

 

 H/H

0.92 (0.62–1.36)

0.026

0.349 (0.206–0.592)

< 0.001

FcγRIIIa

 F/F

1.95 (0.65–2.38)

0.79

11.51 (6.71–19.77)

< 0.001

 F/V

1.00

 

1.00

 

 V/V

1.72 (1.04–2.82)

0.13

0.20 (0.09–0.47)

< 0.001

FcγRIIIb

 NA1/NA1

0.79 (0.48–1.30)

0.354

0.82 (0.43–1.57)

0.545

 NA1/NA2

1.00

 

1.00

 

 NA2/NA2

1.24 (0.85–1.79)

0.263

1.76 (1.15–2.70)

0.009

  1. aOdds Ratio (OR) adjusted with sex and age
  2. bOdds Ratio (OR) adjusted with sex, age and Parasite density
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Malaria Journal

ISSN: 1475-2875

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