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Table 3 Association between individual FcγRIIa, FcγRIIIa and FcγRIIIb genotypes and severity of malaria

From: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

  UM versus MFC SM versus UM
Adjusteda OR (95% CI) P value Adjustedb OR (95% CI) P value
FcγRIIa
 R/R 1.39 (0.89–2.19) 0.15 2.132 (1.287–3.533) 0.003
 H/R 1.00   1.00  
 H/H 0.92 (0.62–1.36) 0.026 0.349 (0.206–0.592) < 0.001
FcγRIIIa
 F/F 1.95 (0.65–2.38) 0.79 11.51 (6.71–19.77) < 0.001
 F/V 1.00   1.00  
 V/V 1.72 (1.04–2.82) 0.13 0.20 (0.09–0.47) < 0.001
FcγRIIIb
 NA1/NA1 0.79 (0.48–1.30) 0.354 0.82 (0.43–1.57) 0.545
 NA1/NA2 1.00   1.00  
 NA2/NA2 1.24 (0.85–1.79) 0.263 1.76 (1.15–2.70) 0.009
  1. aOdds Ratio (OR) adjusted with sex and age
  2. bOdds Ratio (OR) adjusted with sex, age and Parasite density