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Table 6 Logistic regression analysis of individual carrying FcγRIIa, FcγRIIIa, FcγRIIIb genotypes in relation of the levels specific IgG subclasses associated with uncomplicated compared to severe malaria

From: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

FcγRs genotype s

Antimalrial IgG-AMA-1 subclasses

Genotypes

Adjusted ORa (95% CI)

P value

FcgRIIa

IgG1

R/R131

2.3 (1.4–3.4)

0.485

H/R131

1

 

H/H131

0.3 (0.2–0.6)

< 0.001

IgG2

R/R131

3.7 (2.0–6.7)

< 0.001

H/R131

1

 

H/H131

0.5 (0.3–0.8)

0.006

IgG3

R/R131

0.4 (0.2–0.6)

< 0.001

H/R131

1

 

H/H131

1.4 (0.8–2.3)

0.28

IgG4

R/R131

3.2 (1.8–5.7)

< 0.001

H/R131

1

 

H/H131

0.5 (0.3–0.8)

0.006

FcγRIIIa

IgG1

F/F

0.8 (0.5–1.2)

0.272

F/V

1

 

V/V

1.3 (0.8–2.2)

0.326

IgG2

F/F

3.9 (2.4–6.4)

< 0.001

F/V

1

 

V/V

0.4 (0.3–0.7)

0.002

IgG3

F/F

0.2 (0.1–0.4)

< 0.001

F/V

1

 

V/V

1.8 (0.9–3.7)

0.096

IgG4

F/F

3.2 (2.1–5.3)

< 0.001

F/V

1

 

V/V

0.4 (2.0–0.6)

< 0.001

FcγRIIIb

IgG1

NA1/NA1

1.3 (0.7–2.4)

0.47

NA1/NA2

1

 

NA2/NA2

0.9 (0.6–1.4)

0.71

IgG2

NA1/NA1

1.0 (0.6–1.9)

0.94

NA1/NA2

1

 

NA2/NA2

1.4 (0.9–2.1)

0.14

IgG3

NA1/NA1

0.9 (0.5–1.7)

0.72

NA1/NA2

1

 

NA2/NA2

0.9 (0.6–1.4)

0.71

IgG4

NA1/NA1

1.2 (0.6–2.2)

0.61

NA1/NA2

1

 

NA2/NA2

1.7 (1.1–2.7)

0.011

  1. aOR represent odds ratios while CI represents confidence intervals. “OR” adjusted with parasite density. Higher levels of antimalarial IgG subclasses among uncomplicated malaria patients were assigned 0 while higher levels antimalarial IgG subclasses among severe malaria patients were assigned 1 in the logistic regression analysis. OR above 1 represented value associated to higher levels antimalarial IgG subclasses among severe malaria patients while less than 1 value represented higher levels antimalarial IgG subclasses among uncomplicated malaria patients