FcγRs genotype s | Antimalrial IgG-AMA-1 subclasses | Genotypes | Adjusted ORa (95% CI) | P value |
---|---|---|---|---|
FcgRIIa | IgG1 | R/R131 | 2.3 (1.4–3.4) | 0.485 |
H/R131 | 1 | |||
H/H131 | 0.3 (0.2–0.6) | < 0.001 | ||
IgG2 | R/R131 | 3.7 (2.0–6.7) | < 0.001 | |
H/R131 | 1 | |||
H/H131 | 0.5 (0.3–0.8) | 0.006 | ||
IgG3 | R/R131 | 0.4 (0.2–0.6) | < 0.001 | |
H/R131 | 1 | |||
H/H131 | 1.4 (0.8–2.3) | 0.28 | ||
IgG4 | R/R131 | 3.2 (1.8–5.7) | < 0.001 | |
H/R131 | 1 | |||
H/H131 | 0.5 (0.3–0.8) | 0.006 | ||
FcγRIIIa | IgG1 | F/F | 0.8 (0.5–1.2) | 0.272 |
F/V | 1 | |||
V/V | 1.3 (0.8–2.2) | 0.326 | ||
IgG2 | F/F | 3.9 (2.4–6.4) | < 0.001 | |
F/V | 1 | |||
V/V | 0.4 (0.3–0.7) | 0.002 | ||
IgG3 | F/F | 0.2 (0.1–0.4) | < 0.001 | |
F/V | 1 | |||
V/V | 1.8 (0.9–3.7) | 0.096 | ||
IgG4 | F/F | 3.2 (2.1–5.3) | < 0.001 | |
F/V | 1 | |||
V/V | 0.4 (2.0–0.6) | < 0.001 | ||
FcγRIIIb | IgG1 | NA1/NA1 | 1.3 (0.7–2.4) | 0.47 |
NA1/NA2 | 1 | |||
NA2/NA2 | 0.9 (0.6–1.4) | 0.71 | ||
IgG2 | NA1/NA1 | 1.0 (0.6–1.9) | 0.94 | |
NA1/NA2 | 1 | |||
NA2/NA2 | 1.4 (0.9–2.1) | 0.14 | ||
IgG3 | NA1/NA1 | 0.9 (0.5–1.7) | 0.72 | |
NA1/NA2 | 1 | |||
NA2/NA2 | 0.9 (0.6–1.4) | 0.71 | ||
IgG4 | NA1/NA1 | 1.2 (0.6–2.2) | 0.61 | |
NA1/NA2 | 1 | |||
NA2/NA2 | 1.7 (1.1–2.7) | 0.011 |