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Table 6 Logistic regression analysis of individual carrying FcγRIIa, FcγRIIIa, FcγRIIIb genotypes in relation of the levels specific IgG subclasses associated with uncomplicated compared to severe malaria

From: Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

FcγRs genotype s Antimalrial IgG-AMA-1 subclasses Genotypes Adjusted ORa (95% CI) P value
FcgRIIa IgG1 R/R131 2.3 (1.4–3.4) 0.485
H/R131 1  
H/H131 0.3 (0.2–0.6) < 0.001
IgG2 R/R131 3.7 (2.0–6.7) < 0.001
H/R131 1  
H/H131 0.5 (0.3–0.8) 0.006
IgG3 R/R131 0.4 (0.2–0.6) < 0.001
H/R131 1  
H/H131 1.4 (0.8–2.3) 0.28
IgG4 R/R131 3.2 (1.8–5.7) < 0.001
H/R131 1  
H/H131 0.5 (0.3–0.8) 0.006
FcγRIIIa IgG1 F/F 0.8 (0.5–1.2) 0.272
F/V 1  
V/V 1.3 (0.8–2.2) 0.326
IgG2 F/F 3.9 (2.4–6.4) < 0.001
F/V 1  
V/V 0.4 (0.3–0.7) 0.002
IgG3 F/F 0.2 (0.1–0.4) < 0.001
F/V 1  
V/V 1.8 (0.9–3.7) 0.096
IgG4 F/F 3.2 (2.1–5.3) < 0.001
F/V 1  
V/V 0.4 (2.0–0.6) < 0.001
FcγRIIIb IgG1 NA1/NA1 1.3 (0.7–2.4) 0.47
NA1/NA2 1  
NA2/NA2 0.9 (0.6–1.4) 0.71
IgG2 NA1/NA1 1.0 (0.6–1.9) 0.94
NA1/NA2 1  
NA2/NA2 1.4 (0.9–2.1) 0.14
IgG3 NA1/NA1 0.9 (0.5–1.7) 0.72
NA1/NA2 1  
NA2/NA2 0.9 (0.6–1.4) 0.71
IgG4 NA1/NA1 1.2 (0.6–2.2) 0.61
NA1/NA2 1  
NA2/NA2 1.7 (1.1–2.7) 0.011
  1. aOR represent odds ratios while CI represents confidence intervals. “OR” adjusted with parasite density. Higher levels of antimalarial IgG subclasses among uncomplicated malaria patients were assigned 0 while higher levels antimalarial IgG subclasses among severe malaria patients were assigned 1 in the logistic regression analysis. OR above 1 represented value associated to higher levels antimalarial IgG subclasses among severe malaria patients while less than 1 value represented higher levels antimalarial IgG subclasses among uncomplicated malaria patients