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Fig. 1 | Malaria Journal

Fig. 1

From: Application of dried blood spot sample pooling strategies for Plasmodium 18S rRNA biomarker testing to facilitate identification of infected persons in large-scale epidemiological studies

Fig. 1

Plasmodium 18S rRNA biomarker correlation between DBS samples and liquid samples. Serial dilutions of P. falciparum cultures containing 4 × 107, 5 × 105, 5 × 104, 5 × 103 and 5 × 102 parasites/mL and 1, 5, 10, 10, and 10 replicates were used to prepare DBS and liquid samples and tested by the standard assay (A, B). The correlation between liquid and DBS samples were > 0.96 (A). Bland–Altman plots displayed biases (DBS-liquid samples) < 0.4 log10 parasites/mL blood (B). Leftover clinical samples were collected from seven infected individuals throughout the course of their treatment to prepare DBS and liquid samples (C). Bland–Altman plots displayed biases close to 0.2 log10 parasites/mL blood. Pf P. falciparum, Pan pan-Plasmodium

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Malaria Journal

ISSN: 1475-2875

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