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Fig. 3 | Malaria Journal

Fig. 3

From: Transcriptome-based analysis of blood samples reveals elevation of DNA damage response, neutrophil degranulation, cancer and neurodegenerative pathways in Plasmodium falciparum patients

Fig. 3

Differential expression analysis between CM and NCM reveals NF-kappaB signalling, immune response, response to herbicide and neutrophil activation amongst GO terms overrepresented in up-regulated genes whereas myeloid cell homeostasis, regulation of axon diameter, haemopoiesis were amongst GO terms highly expressed in downregulated genes. a Most significant GO terms elevated in genes up-regulated between CM and NCM. b Most significant GO terms elevated in genes down-regulated between CM and NCM. c Hierarchical cluster analysis and heatmap of genes up-regulated (ratio > 2, p < 0.05) and down-regulated (ratio < 0.5, p < 0.05) between CM and NCM. The cluster of genes up-regulated in CM is marked with red shading, the cluster of down-regulated genes with green shading. The genes associated with both clusters are listed in d. IL18R1 among the up-regulated genes is indicative of the involvement of IL18-signalling

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Malaria Journal

ISSN: 1475-2875

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