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Fig. 4 | Malaria Journal

Fig. 4

From: Transcriptome-based analysis of blood samples reveals elevation of DNA damage response, neutrophil degranulation, cancer and neurodegenerative pathways in Plasmodium falciparum patients

Fig. 4

Metascape analysis of genes differentially expressed between CM and NCM reveals protein interaction network and involvement of the transcription factors IRF1, STAT1/3, NFKB1 and RELA in the gene regulatory networks of the CM state. a Protein interaction network generated with Metascape from genes differentially expressed between CM and NCM. A central cluster is located around MMP8 and MMP8 which have been associated with CM by Polimeni and Prato, due to their potential to disrupt the subendothelial basement membrane and process and regulate cytokines [16]. Moreover, Polimeni and Prato propose that haemozoin promotes NF-kappaB-controlled gene expression of MMP9. b Heatmap of transcription factors generated with Metascape employing the TRRUST method using genes differentially expressed between CM and NCM. Graphics were created with Metascape (https://metascape.org/), [42]

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Malaria Journal

ISSN: 1475-2875

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