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Table 1 Characteristics of the studies included in the systematic review and meta-analysis of the performance of RDT, microscopy, LAMP and PCR

From: Performance of rapid diagnostic tests, microscopy, loop-mediated isothermal amplification (LAMP) and PCR for malaria diagnosis in Ethiopia: a systematic review and meta-analysis

S.N Author/year Population Sample size TP FP FN TN Index
test
RDT target antigen Reference test
1 Hailu et al. (2014) Malaria suspected patients 398 201 4 0 193 RDT HRP-2 & Pv-pLDH Microscopy
2 Moges et al. (2012) Febrile patients 254 95 5 9 145 RDT HRP-2 and pan pLDH Microscopy
3 Eticha et al. (2020) Febrile patients 160 76 4 4 76 RDT HRP-2 and Pv-pLDH Microscopy
4 Woyessa et al. (2013a) Febrile patients (household survey) 796 79 24 8 693 RDT HRP-2 and Pv-pLDH Microscopy
5 Woyessa et al. (2013b) Febrile patients (Health center) 1598 375 208 17 1015 RDT HRP-2 and Pv-pLDH Microscopy
6 Tadesse et al. (2016) Febrile patients 374 265 2 7 100 RDT HRP-2 and pan pLDH Microscopy
7 Feleke et al. (2017) Febrile patients 320 40 3 1 276 RDT HRP-2 and pan pLDH Microscopy
8 Alemayehu et al. (2020a) Malaria suspected patients 406 103 20 4 279 RDT HRP-2 Microscopy
9 Alemyehu et al. (2020b) Malaria suspected 406 95 3 12 269 RDT PfLDH Microscopy
10 Golassa et al. (2015a) Asymptomatic individuals 1094 46 44 8 996 RDT HRP-2 & Pv-pLDH Microscopy
11 Tadesse et al. (2001) Febrile patients 100 45 4 5 46 RDT HRP-2 & Pv/Pf-pLDH Microscopy
12 Mohammed et al. (2012) Febrile patients 1293 111 8 7 32 RDT HRP-2 Microscopy
13 Mekonnen et al. (2010) Febrile patients 240 115 0 5 120 RDT HRP-2 & Pv-pLDH Microscopy
14 Bayisa et al. (2015) Febrile patients 384 97 11 10 266 RDT HRP-2 & Pv-pLDH Microscopy
15 Abebe et al. (2018) Febrile patients 417 149 2 7 259 RDT HRP-2 & pan pLDH Microscopy
16 Chanie et al. (2011) Febrile patients 1092 223 20 3 846 RDT HRP-2 & Pv-pLDH Microscopy
17 Sharew et al. (2009a) Febrile patients 668 158 25 1 484 RDT HRP-2 Microscopy
18 Sharew et al. (2009b) Febrile patients 668 314 17 2 335 RDT HRP-2 & Pv-pLDH Microscopy
19 Endeshaw et al. (2012) Febrile patients 1997 376 64 99 1454 RDT HRP-2 & pan pLDH Microscopy
20 Tekeste et al. (2012) Febrile patients 400 200 11 10 179 RDT HRP-2 Microscopy
21 Morankar e.al (2011) Febrile patients 929 40 5 3 881 RDT HRP-2 Microscopy
22 Tegegne et al. (2017a) Symptomatic and asymptomatic 330 31 0 5 294 RDT HRP-2 and pan pLDH Microscopy
23 Ashton et al. (2010a) Febrile patients 2383 526 190 26 1641 RDT HRP-2 and pan pLDH Microscopy
24 Beyene et al. (2016) Febrile patients 977 135 33 26 783 RDT HRP-2 and Pv/Pf-pLDH Microscopy
25 Ashton et al. (2010b) Febrile patients 2383 529 208 23 1623 RDT HRP-2 and pan pLDH Microscopy
26 Ashton et al. (2010c) Febrile patients 2383 525 194 27 1637 RDT HRP-2 & pan-aldolase Microscopy
27 Alemayehu et al. (2020c) Febrile patients 406 104 19 32 250 RDT HRP-2 PCR
28 Alemayehu et al. (2020d) Febrile patients 406 95 3 41 266 RDT PfLDH PCR
29 Golassa et al. (2015c) Febrile patients 94 61 18 8 7 RDT HRP-2 & Pv-pLDH PCR
30 Tegegne et al. (2017b) Symptomatic and asymptomatic 330 30 1 51 248 RDT HRP-2 and pan pLDH PCR
31 Getnet et al. (2015) Asymptomatic individuals 359 61 19 37 243 RDT HRP-2 and pan pLDH PCR
32 Golassa et al. (2013b) Clinical & sub-clinical patients 500 80 20 77 323 RDT HRP-2 and Pv-pLDH PCR
33 Alemu et al. (2014) Malaria suspected patients 297 183 5 39 75 Microscopy NA PCR
34 Alemayehu et al. (2020e) Malaria suspected patients 406 105 2 31 267 Microscopy NA PCR
35 Golossa et al. (2015b) Asymptomatic individuals 94 42 5 27 20 Microscopy NA PCR
36 Sema et al. (2015a) Febrile patients 82 30 0 1 51 Microscopy NA PCR
37 Golassa et al. (2013a) Clinical & sub-clinical patients 454 49 6 77 323 Microscopy NA PCR
38 Díaz et al. (2015) Malaria suspected patients 1209 604 23 184 398 Microscopy NA PCR
39 Girma et al. (2018b) Asymptomatic individuals 562 118 7 0 437 LAMP NA Microscopy
40 Sema et al. (2015c) Malaria suspected patients 82 30 8 0 44 LAMP NA Microscopy
41 Tegegneet al. (2017a) Symptomatic and asymptomatic 87 10 5 0 72 LAMP NA Microscopy
42 Girma et al. (2018a) Asymptomatic individuals 562 121 4 0 437 LAMP NA PCR
43 Sema et al. (2015b) Febrile patients 82 31 7 0 44 LAMP NA PCR
44 Tegegne et al. (2017b) Symptomatic and asymptomatic 87 10 5 0 72 LAMP NA PCR
45 Tadesse G. et al. (2020a) Symptomatic and asymptomatic 435 6 0 3 426 RDT NA LAMP
46 Tadesse G. et al. (2020b) Symptomatic and asymptomatic 435 5 0 4 426 Microscopy NA LAMP
  1. NA, not applicable; RDT, rapid diagnostic test; PCR: polymerase chain reaction; LAMP, loop-mediated isothermal amplification; TP, true positive; FP, false positive; FN, false negative; TN, true negative; HRP-2, histidine rich protein-2; Pv-pLDH, Plasmodium vivax-Plasmodium lactate dehydrogenase