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Table 1 Characteristics of the studies included in the systematic review and meta-analysis of the performance of RDT, microscopy, LAMP and PCR

From: Performance of rapid diagnostic tests, microscopy, loop-mediated isothermal amplification (LAMP) and PCR for malaria diagnosis in Ethiopia: a systematic review and meta-analysis

S.N

Author/year

Population

Sample size

TP

FP

FN

TN

Index

test

RDT target antigen

Reference test

1

Hailu et al. (2014)

Malaria suspected patients

398

201

4

0

193

RDT

HRP-2 & Pv-pLDH

Microscopy

2

Moges et al. (2012)

Febrile patients

254

95

5

9

145

RDT

HRP-2 and pan pLDH

Microscopy

3

Eticha et al. (2020)

Febrile patients

160

76

4

4

76

RDT

HRP-2 and Pv-pLDH

Microscopy

4

Woyessa et al. (2013a)

Febrile patients (household survey)

796

79

24

8

693

RDT

HRP-2 and Pv-pLDH

Microscopy

5

Woyessa et al. (2013b)

Febrile patients (Health center)

1598

375

208

17

1015

RDT

HRP-2 and Pv-pLDH

Microscopy

6

Tadesse et al. (2016)

Febrile patients

374

265

2

7

100

RDT

HRP-2 and pan pLDH

Microscopy

7

Feleke et al. (2017)

Febrile patients

320

40

3

1

276

RDT

HRP-2 and pan pLDH

Microscopy

8

Alemayehu et al. (2020a)

Malaria suspected patients

406

103

20

4

279

RDT

HRP-2

Microscopy

9

Alemyehu et al. (2020b)

Malaria suspected

406

95

3

12

269

RDT

PfLDH

Microscopy

10

Golassa et al. (2015a)

Asymptomatic individuals

1094

46

44

8

996

RDT

HRP-2 & Pv-pLDH

Microscopy

11

Tadesse et al. (2001)

Febrile patients

100

45

4

5

46

RDT

HRP-2 & Pv/Pf-pLDH

Microscopy

12

Mohammed et al. (2012)

Febrile patients

1293

111

8

7

32

RDT

HRP-2

Microscopy

13

Mekonnen et al. (2010)

Febrile patients

240

115

0

5

120

RDT

HRP-2 & Pv-pLDH

Microscopy

14

Bayisa et al. (2015)

Febrile patients

384

97

11

10

266

RDT

HRP-2 & Pv-pLDH

Microscopy

15

Abebe et al. (2018)

Febrile patients

417

149

2

7

259

RDT

HRP-2 & pan pLDH

Microscopy

16

Chanie et al. (2011)

Febrile patients

1092

223

20

3

846

RDT

HRP-2 & Pv-pLDH

Microscopy

17

Sharew et al. (2009a)

Febrile patients

668

158

25

1

484

RDT

HRP-2

Microscopy

18

Sharew et al. (2009b)

Febrile patients

668

314

17

2

335

RDT

HRP-2 & Pv-pLDH

Microscopy

19

Endeshaw et al. (2012)

Febrile patients

1997

376

64

99

1454

RDT

HRP-2 & pan pLDH

Microscopy

20

Tekeste et al. (2012)

Febrile patients

400

200

11

10

179

RDT

HRP-2

Microscopy

21

Morankar e.al (2011)

Febrile patients

929

40

5

3

881

RDT

HRP-2

Microscopy

22

Tegegne et al. (2017a)

Symptomatic and asymptomatic

330

31

0

5

294

RDT

HRP-2 and pan pLDH

Microscopy

23

Ashton et al. (2010a)

Febrile patients

2383

526

190

26

1641

RDT

HRP-2 and pan pLDH

Microscopy

24

Beyene et al. (2016)

Febrile patients

977

135

33

26

783

RDT

HRP-2 and Pv/Pf-pLDH

Microscopy

25

Ashton et al. (2010b)

Febrile patients

2383

529

208

23

1623

RDT

HRP-2 and pan pLDH

Microscopy

26

Ashton et al. (2010c)

Febrile patients

2383

525

194

27

1637

RDT

HRP-2 & pan-aldolase

Microscopy

27

Alemayehu et al. (2020c)

Febrile patients

406

104

19

32

250

RDT

HRP-2

PCR

28

Alemayehu et al. (2020d)

Febrile patients

406

95

3

41

266

RDT

PfLDH

PCR

29

Golassa et al. (2015c)

Febrile patients

94

61

18

8

7

RDT

HRP-2 & Pv-pLDH

PCR

30

Tegegne et al. (2017b)

Symptomatic and asymptomatic

330

30

1

51

248

RDT

HRP-2 and pan pLDH

PCR

31

Getnet et al. (2015)

Asymptomatic individuals

359

61

19

37

243

RDT

HRP-2 and pan pLDH

PCR

32

Golassa et al. (2013b)

Clinical & sub-clinical patients

500

80

20

77

323

RDT

HRP-2 and Pv-pLDH

PCR

33

Alemu et al. (2014)

Malaria suspected patients

297

183

5

39

75

Microscopy

NA

PCR

34

Alemayehu et al. (2020e)

Malaria suspected patients

406

105

2

31

267

Microscopy

NA

PCR

35

Golossa et al. (2015b)

Asymptomatic individuals

94

42

5

27

20

Microscopy

NA

PCR

36

Sema et al. (2015a)

Febrile patients

82

30

0

1

51

Microscopy

NA

PCR

37

Golassa et al. (2013a)

Clinical & sub-clinical patients

454

49

6

77

323

Microscopy

NA

PCR

38

Díaz et al. (2015)

Malaria suspected patients

1209

604

23

184

398

Microscopy

NA

PCR

39

Girma et al. (2018b)

Asymptomatic individuals

562

118

7

0

437

LAMP

NA

Microscopy

40

Sema et al. (2015c)

Malaria suspected patients

82

30

8

0

44

LAMP

NA

Microscopy

41

Tegegneet al. (2017a)

Symptomatic and asymptomatic

87

10

5

0

72

LAMP

NA

Microscopy

42

Girma et al. (2018a)

Asymptomatic individuals

562

121

4

0

437

LAMP

NA

PCR

43

Sema et al. (2015b)

Febrile patients

82

31

7

0

44

LAMP

NA

PCR

44

Tegegne et al. (2017b)

Symptomatic and asymptomatic

87

10

5

0

72

LAMP

NA

PCR

45

Tadesse G. et al. (2020a)

Symptomatic and asymptomatic

435

6

0

3

426

RDT

NA

LAMP

46

Tadesse G. et al. (2020b)

Symptomatic and asymptomatic

435

5

0

4

426

Microscopy

NA

LAMP

  1. NA, not applicable; RDT, rapid diagnostic test; PCR: polymerase chain reaction; LAMP, loop-mediated isothermal amplification; TP, true positive; FP, false positive; FN, false negative; TN, true negative; HRP-2, histidine rich protein-2; Pv-pLDH, Plasmodium vivax-Plasmodium lactate dehydrogenase