Genetic variation of Plasmodium falciparum histidine-rich protein 2 and 3 in Assosa zone, Ethiopia: its impact on the performance of malaria rapid diagnostic tests

Table 2 Distribution of PfHRP2 and PfHRP3 Amino acids repeat in P. falciparum isolates in Assosa zone, Northwest Ethiopia

Type of repeat	Amino acid repeat sequence*	PfHRP2 (n = 48)		PfHRP3 (n = 88)
Type of repeat	Amino acid repeat sequence*	No (%)	Min to Max number	No (%)	Min to Max number
1	AHHAHHVAD	48 (100)	1–5	83 (94.3)	0–3
2	AHHAHHAAD	48 (100)	1–15	0 (0.0)	0
3	AHHAHHAAY	42 (87.5)	0–2	0 (0.0)	0
4	AHH	20 (41.7)	0–3	78 (88.6)	0–1
5	AHHAHHASD	36 (75.0)	0–1	0 (0.0)	0
6	AHHATD	46 (95.8)	0–6	0 (0.0)	0
7	AHHAAD	48 (100)	3–13	85 (96.6)	0–2
8	AHHAAY	44 (91.7)	0–2	0 (0.0)	0
9	AAY	0 (0.0)	0–0	0 (0.0)	0
10	AHHAAAHHATD	46 (95.8)	0–2	0 (0.0)	0
11	AHN	0 (0.0)	0–0	0 (0.0)	0
12	AHHAAAHHEAATH	5 (10.4)	0–1	0 (0.0)	0
13	AHHASD	5 (10.4)	0–1	0 (0.0)	0
14	AHHAHHATD	0 (0.0)	0	0 (0.0)	0
15	AHHAHHAAN	0 (0.0)	0–0	84 (95.5)	0–2
16	AHHAAN	0 (0.0)	0–0	88 (100)	7–16
17	AHHDG	0 (0.0)	0–0	88 (100)	1–8
18	AHHDD	0 (0.0)	0–0	87 (98.9)	0–4
19	AHHAA	0 (0.0)	0–0	0 (0.0)	0
20	SHHDD	0 (0.0)	0–0	87 (98.9)	0–2
21	AHHAHHATY	0 (0.0)	0–0	0 (0.0)	0
22	AHHAHHAGD	0 (0.0)	0–0	0 (0.0)	0
23	ARHAAD	0 (0.0)	0–0	0 (0.0)	0
24	AHHTHHAAD	0 (0.0)	0–0	0 (0.0)	0–0

*PfHRP2 and PfHRP3 amino acid repeat motif as describe by Baker et al. [11]
N: Total number of PfHRP2 and PfHRP3 amino acid sequence in P. falciparum isolates
Min: Minimum number of amino acid repeat, Max: maximum number of amino acid repeat

ISSN: 1475-2875