Genetic variation of Plasmodium falciparum histidine-rich protein 2 and 3 in Assosa zone, Ethiopia: its impact on the performance of malaria rapid diagnostic tests

Table 4 Frequency of PfHRP2 sequence groups based on the Baker’s model and PfHRP2 RDT results (n = 48)

Group	Frequency (N = 48)	Prediction of PfHRP2 RDT Positivity	Microscopy > 250 parasite/µl
Group	No (%)	No (%)	No (%)
A	11 (22.9)	8 (72.7)	8 (100)
B	26 (54.2)	19 (73.1)	14 (73.7)
C	10 (20.8)	7 (70.0)	6 (85.7)
I	1 (2.1)	1 (100)	1 (100)

PfHRP2 sequence isolates were classified into four groups according to the frequency number of types 2 × type 7 repeats: group A (≥ 100, very sensitive), group B (50–99, sensitive), group C (< 43, non-sensitive) and group I (44–49, borderline) as describe previously (Baker et al. [8])

ISSN: 1475-2875