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Table 1 Extracted functional interactions between manually annotated proteins

From: Network-driven analysis of human–Plasmodium falciparum interactome: processes for malaria drug discovery and extracting in silico targets

Interaction
source
Number of
Interactions
Number of proteins Number of reviewed proteins Number of pair-wise interactions between reviewed proteins References
A. Functional interactions between annotated Plasmodium falciparum proteins
 LaCount P. falciparum PPI 2864 1308 62 17 [35]
 Wuchty et al. in silico Plasmodium PPI (1) 19,979 2321 85 74 [31]
 Wuchty et al. experimental PPI (2) 1428 361 12 11 [32]
 Wuchty experimental P. falciparum PPI (3) 5458 1986 91 32 [33]
 Wuchty et al. experimental P. falciparum PPI (4) 4918 1872 81 15 [34]
 IntAct 2916 1343 67 26 [28]
 InterPro 1013 256 98 241 [26]
 Scored BLAST sequence similarity 1090 (BLAST) 163 130 231 [85]
 STRING 617 163 114 386 [86]
B. Functional interactions between annotated human proteins
 Reactome 79,619 8059 5029 19,736 [27]
 Score BLAST sequence similarity 3,807,888
(BLAST)
20,395 9611 143,533 [85]
 InterPro 2,646,550 35,928 17,797 231,799 [26]
 Bossi and Lerner 80,922 10,229 8416 54,238 [36]
 STRING 11,759,454 19,354 18,836 5,244,655 [86]
 IntAct 456,263 35,770 16,061 169,627 [28]