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Table 1 Extracted functional interactions between manually annotated proteins

From: Network-driven analysis of human–Plasmodium falciparum interactome: processes for malaria drug discovery and extracting in silico targets

Interaction

source

Number of

Interactions

Number of proteins

Number of reviewed proteins

Number of pair-wise interactions between reviewed proteins

References

A. Functional interactions between annotated Plasmodium falciparum proteins

 LaCount P. falciparum PPI

2864

1308

62

17

[35]

 Wuchty et al. in silico Plasmodium PPI (1)

19,979

2321

85

74

[31]

 Wuchty et al. experimental PPI (2)

1428

361

12

11

[32]

 Wuchty experimental P. falciparum PPI (3)

5458

1986

91

32

[33]

 Wuchty et al. experimental P. falciparum PPI (4)

4918

1872

81

15

[34]

 IntAct

2916

1343

67

26

[28]

 InterPro

1013

256

98

241

[26]

 Scored BLAST sequence similarity

1090 (BLAST)

163

130

231

[85]

 STRING

617

163

114

386

[86]

B. Functional interactions between annotated human proteins

 Reactome

79,619

8059

5029

19,736

[27]

 Score BLAST sequence similarity

3,807,888

(BLAST)

20,395

9611

143,533

[85]

 InterPro

2,646,550

35,928

17,797

231,799

[26]

 Bossi and Lerner

80,922

10,229

8416

54,238

[36]

 STRING

11,759,454

19,354

18,836

5,244,655

[86]

 IntAct

456,263

35,770

16,061

169,627

[28]