Table 3 Statistically significant biological processes and enriched pathways of key human malaria-associated genes inferred from gene ontology and KEGG database

Enriched biological process

 Go:0042346

Positive regulation of nfkappab import into nucleus

2.00161e−05

0.00432

 Go:0045348

Positive regulation of mhc

Class ii biosynthetic process

2.40637e−06

0.00052

 Go:0032689

Negative regulation of

Interferon-gamma production

3.10034e−05

0.00670

 Go:0007157

Heterophilic cell–cell adhesion

Via plasma membrane cell adhesion molecules

0.00012

0.02714

 Go:2000352

Negative regulation of endothelial

Cell apoptotic process

2.70760e−05

0.00585

 Go:0032715

Negative regulation of interleukin-6 production

8.99764e−08

1.9434e-05

 Go:2000343

Positive regulation of chemokine (c-x-c motif) ligand

1.68841e−05

0.00364

 Go:0032729

Positive regulation of

Interferon-gamma production

0.00012

0.02713

  Go:0070374

Positive regulation of erk1

And erk2 cascade

2.8883e−05

0.00623

 Go:0050830

Defence response to gram-positive bacterium

2.65221e−05

0.00572

 Go:0034116

Positive regulation of heterotypic cell–cell adhesion

1.68841e−05

0.00364

 Go:0044130

Negative regulation of

Growth of symbiont in host

6.07930e−06

0.00131

 Go:0030198

Extracellular matrix organization

5.39819e−05

0.01166

 Go:0045416

Positive regulation of

Interleukin-8 biosynthetic process

2.40637e−06

0.00051

 Go:0032755

Positive regulation of

Interleukin-6 production

0.00016

0.03562

 Go:0002740

Negative regulation of cytokine

Secretion involved in immune response

1.00303e−06

0.00021

 Go:0045429

Positive regulation of nitric

Oxide biosynthetic process

1.23374e−07

2.665e−05

 Go:0043032

Positive regulation of

Macrophage activation

1.02165e−05

0.00220

 Go:1904999

Positive regulation of leukocyte

Adhesion to arterial endothelial

Cell

2.00663e−07

4.3343e−05

 Go:0031663

Lipopolysaccharide mediated

Signalling pathway

2.42641e−08

5.2410e−06

 Go:1904707

Positive regulation of vascular

Smooth muscle cell proliferation

0.00016

0.03663

 Go:0032800

Receptor biosynthetic process

6.68766e−07

0.00014

 Go:1900227

Positive regulation of nlrp3 inflammasome complex assembly

2.70759e−05

0.00584

A. Enriched pathway

 Kegg pathway id

Kegg-pathway-name

P-value

Adjusted p-value

 Hsa05144

Malaria

0.0

0.0

 Hsa05310

Asthma

6.52960e−07

7.966e−05

 Hsa04145

Phagosome

1.46003e−06

0.00017

 Hsa05146

Amoebiasis

0.00014

0.01745

 Hsa04640

Hematopoietic cell lineage

1.70661e−06

0.00020

 Hsa05330

Allograft rejection

3.03329e−06

0.00037

 Hsa05133

Pertussis

8.77858e−06

0.00107

 Hsa04940

Type i diabetes mellitus

9.00124e−05

0.01098

 Hsa05162

Measles

8.93218e−05

0.0108

 Hsa04650

Natural killer cell mediated cytotoxicity

0.00014

0.01724

 Hsa04657

Il—17 signalling pathway

0.00037

0.04624

 Hsa05152

Tuberculosis

1.92895e−10

2.35332e−08

 Hsa05150

Staphylococcus aureus infection

4.40440e−08

5.37336e−06

 Hsa05142

Chagas disease (american trypanosomiasis)

7.77032e−05

0.00947

 Hsa05143

African trypanosomiasis

7.32790e−10

8.9400e-08

 Hsa05140

Leishmaniasis

1.16192e−11

1.41754e−09

 Hsa05321

Inflammatory bowel disease (ibd)

9.68744e−08

1.18186e−05

 Hsa05322

Systemic lupus erythematosus

3.51918e−05

0.00429

 Hsa05323

Rheumatoid arthritis

0.00027

0.03331

 Hsa05320

Autoimmune thyroid disease

9.62632e−06

0.00117

 Hsa05332

Graft—versus—host disease

0.00010

0.01229