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Table 4 Shortest paths linking O00206 (TLR4) and parasite hub nodes within the host–pathogen unified functional network

From: Network-driven analysis of human–Plasmodium falciparum interactome: processes for malaria drug discovery and extracting in silico targets

Host candidate key protein Mediator Mediator gene name [OMIM ID] Mediator description Parasite candidate key protein Potential parasite adaptive biological process
A. Shortest paths linking O00206 and C6KTB7 (SET1) nodes within the host–pathogen unified functional network
 O00206 Q9BYH8 NFKBIZ [MIM: 608004] NF-kappa-B inhibitor zeta C6KTB7 Inflammatory response; T cell receptor signalling pathway
 O00206 Q05823 RNASEL [MIM: 180435] 2-5A-dependent ribonuclease C6KTB7 Interferon alpha/beta signalling, positive regulation of transcription by RNA polymerase II
 O00206 Q5S007 LRRK2 [MIM: 609007] Leucine-rich repeat serine/threonine-protein kinase 2 C6KTB7 Activation of MAPK activity;
 O00206 Q38SD2 LRRK1 [MIM: 610986] Leucine-rich repeat serine/threonine-protein kinase 1 C6KTB7 Positive regulation of intracellular signal transduction
 O00206 O75762 TRPA1 [MIM: 604775] Transient receptor potential cation channel subfamily A member 1 C6KTB7 Cell surface receptor signalling pathway
 O00206 Q96HA7 TONSL [MIM: 604546] Tonsoku-like protein C6KTB7 Cytoplasmic sequestering of transcription factor
 O00206 Q00653 NFKB2 [MIM: 164012] Nuclear factor NF-kappa-B p100 subunit C6KTB7 Inflammatory response; innate immune response; NIK/NF-kappaB signalling; negative regulation of transcription by RNA polymerase II
 O00206 P25963 NFKBIA [MIM: 164008] NF-kappa-B inhibitor alpha C6KTB7 Positive regulation of inflammatory response; apoptotic process; I-kappaB kinase/NF-kappaB signalling
 O00206 P46531 NOTCH1 [MIM: 190198] Neurogenic locus notch homolog protein 1 C6KTB7 Immune response
 O00206 P20749 BCL3 [MIM: 109560] B-cell lymphoma 3 protein C6KTB7 Regulation of apoptotic process; regulation of interferon-gamma production; T-helper 1 type immune response; positive regulation of interferon-gamma production
 O00206 P42771 CDKN2A [MIM: 600160] Cyclin-dependent kinase inhibitor 2A C6KTB7 Apoptotic process;
 O00206 Q8NI38 NFKBID [MIM: 618887] NF-kappa-B inhibitor delta C6KTB7 Inflammatory response; innate immune response;
 O00206 P19838 NFKB1 [MIM: 164011] Nuclear factor NF-kappa-B p105 subunit C6KTB7 Apoptotic process; inflammatory response; innate immune response; regulation of transcription by RNA polymerase II
 O00206 Q8NDB2 BANK1 [MIM: 610292] B-cell scaffold protein with ankyrin repeats C6KTB7 B cell activation; positive regulation of interleukin-6 production
 O00206 Q15653 NFKBIB [MIM: 604495] NF-kappa-B inhibitor beta C6KTB7 Signal transduction
B. Shortest paths linking O00206 and C6KTD2 within the host–pathogen unified functional network
 O00206 Q13114 TRAF3 [MIM: 601896] TNF receptor-associated factor 3 C6KTD2 Apoptotic process; innate immune response; toll-like receptor signalling pathway; regulation of interferon-beta production; positive regulation of JNK cascade;
 O00206 Q86WT6 TRIM69 [MIM: 616017] E3 ubiquitin-protein ligase TRIM69 C6KTD2 Apoptotic process
 O00206 Q12933 TRAF2 [MIM: 601895] TNF receptor-associated factor 2 C6KTD2 Positive regulation of JNK cascade; apoptotic process;
 O00206 Q9UPN9 TRIM33 [MIM: 605769] E3 ubiquitin-protein ligase TRIM33 C6KTD2 Negative regulation of transcription by RNA polymerase II;
 O00206 P55895 RAG2 [MIM: 179616] V(D)J recombination-activating protein 2 C6KTD2 B cell homeostatic proliferation;
 O00206 O75626 PRDM1 [MIM: 603423] PR domain zinc finger protein 1 C6KTD2 Adaptive immune response; innate immune response; negative regulation of transcription by RNA polymerase II;
 O00206 Q96CA5 BIRC7 [MIM: 605737] Baculoviral IAP repeat-containing protein 7 C6KTD2 Apoptotic process
 O00206 Q8NHM5 KDM2B [MIM: 609078] Lysine-specific demethylase 2B C6KTD2 Negative regulation of transcription by RNA polymerase II; apoptotic process;
 O00206 Q9BUZ4 TRAF4 [MIM: 602464] TNF receptor-associated factor 4 C6KTD2 Apoptotic process; regulation of I-kappaB kinase/NF-kappaB signalling;
 O00206 Q96P53 WDFY2 [MIM: 610418] WD repeat and FYVE domain-containing protein 2 C6KTD2 Positive regulation of protein phosphorylation
 O00206 P15918 RAG1 [MIM: 179615] V(D)J recombination-activating protein 1 C6KTD2 adaptive immune response; immune response;
 O00206 P19474 TRIM21 [MIM: 109092] E3 ubiquitin-protein ligase TRIM21 C6KTD2 Innate immune response; response to interferon-gamma
 O00206 Q9Y4K3 TRAF6 [MIM: 602355] TNF receptor-associated factor 6 C6KTD2 Activation of MAPK activity; positive regulation of JNK cascade; apoptotic process; toll-like receptor signalling pathway; regulation of transcription by RNA polymerase II
 O00206 Q6PCT2 FBXL19 [MIM: 609085] F-box/LRR-repeat protein 19 C6KTD2 Post-translational protein modification
 O00206 Q14258 TRIM25 [MIM: 600453] E3 ubiquitin/ISG15 ligase TRIM25 C6KTD2 Innate immune response;
 O00206 Q9UNE7 STUB1 [MIM: 607207] E3 ubiquitin-protein ligase CHIP C6KTD2 Protein ubiquitination
 O00206 Q15075 EEA1 [MIM: 605070] Early endosome antigen 1 C6KTD2 Endocytosis
 O00206 Q8IWB7 WDFY1 [MIM: 618080] WD repeat and FYVE domain-containing protein 1 C6KTD2 Positive regulation of toll-like receptor 3 and 4 signalling pathway
 O00206 Q09472 EP300 [MIM: 602700] Histone acetyltransferase p300 C6KTD2 Apoptotic process; positive regulation of NIK/NF-kappaB signalling
 O00206 Q8IYM9 TRIM22 [MIM: 606559] E3 ubiquitin-protein ligase TRIM22 C6KTD2 positive regulation of I-kappaB kinase/NF-kappaB signalling
 O00206 Q9Y2K7 KDM2A [MIM: 605657] Lysine-specific demethylase 2A C6KTD2 Histone H3-K36 demethylation
 O00206 Q9NQV6 PRDM10 [MIM: 618319] PR domain zinc finger protein 10 C6KTD2 Positive regulation of transcription by RNA polymerase II
 O00206 Q92793 CREBBP [MIM: 600140] CREB-binding protein C6KTD2 Positive regulation of transcription by RNA polymerase II; apoptotic process
 O00206 Q6UWE0 LRSAM1 [MIM: 610933] E3 ubiquitin-protein ligase LRSAM1 C6KTD2 Ubiquitin-dependent endocytosis;
 O00206 Q8WVD3 RNF138 [MIM: 616319] E3 ubiquitin-protein ligase RNF138 C6KTD2 Protein ubiquitination
 O00206 Q8TCQ1 MARCHF1 [MIM: 613331] E3 ubiquitin-protein ligase MARCHF1 C6KTD2 Immune response
 O00206 Q6Q0C0 TRAF7 [MIM: 606692] E3 ubiquitin-protein ligase TRAF7 C6KTD2 Apoptotic process; positive regulation of MAPK cascade
 O00206 O00463 TRAF5 [MIM: 602356] TNF receptor-associated factor 5 C6KTD2 Apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signalling; positive regulation of JNK cascade;
 O00206 Q13233 MAP3K1 [MIM: 600982] Mitogen-activated protein kinase kinase kinase 1 C6KTD2 Activation of protein kinase activity
 O00206 P98170 XIAP [MIM: 300079] E3 ubiquitin-protein ligase XIAP C6KTD2 Regulation of innate immune response; regulation of inflammatory response; apoptic process
 O00206 Q6ZMZ0 RNF19B [MIM: 610872] E3 ubiquitin-protein ligase RNF19B C6KTD2 Adaptive immune response
 O00206 O14964 HGS [MIM: 604375] Hepatocyte growth factor-regulated tyrosine kinase substrate C6KTD2 Regulation of MAP kinase activity; positive regulation of gene expression
 O00206 Q9NWF9 RNF216 [MIM:] E3 ubiquitin-protein ligase RNF216 C6KTD2 Apoptotic process