Table 4 Shortest paths linking O00206 (TLR4) and parasite hub nodes within the host–pathogen unified functional network
Host candidate key protein | Mediator | Mediator gene name [OMIM ID] | Mediator description | Parasite candidate key protein | Potential parasite adaptive biological process |
|---|---|---|---|---|---|
A. Shortest paths linking O00206 and C6KTB7 (SET1) nodes within the host–pathogen unified functional network | |||||
 O00206 | Q9BYH8 | NFKBIZ [MIM: 608004] | NF-kappa-B inhibitor zeta | C6KTB7 | Inflammatory response; T cell receptor signalling pathway |
 O00206 | Q05823 | RNASEL [MIM: 180435] | 2-5A-dependent ribonuclease | C6KTB7 | Interferon alpha/beta signalling, positive regulation of transcription by RNA polymerase II |
 O00206 | Q5S007 | LRRK2 [MIM: 609007] | Leucine-rich repeat serine/threonine-protein kinase 2 | C6KTB7 | Activation of MAPK activity; |
 O00206 | Q38SD2 | LRRK1 [MIM: 610986] | Leucine-rich repeat serine/threonine-protein kinase 1 | C6KTB7 | Positive regulation of intracellular signal transduction |
 O00206 | O75762 | TRPA1 [MIM: 604775] | Transient receptor potential cation channel subfamily A member 1 | C6KTB7 | Cell surface receptor signalling pathway |
 O00206 | Q96HA7 | TONSL [MIM: 604546] | Tonsoku-like protein | C6KTB7 | Cytoplasmic sequestering of transcription factor |
 O00206 | Q00653 | NFKB2 [MIM: 164012] | Nuclear factor NF-kappa-B p100 subunit | C6KTB7 | Inflammatory response; innate immune response; NIK/NF-kappaB signalling; negative regulation of transcription by RNA polymerase II |
 O00206 | P25963 | NFKBIA [MIM: 164008] | NF-kappa-B inhibitor alpha | C6KTB7 | Positive regulation of inflammatory response; apoptotic process; I-kappaB kinase/NF-kappaB signalling |
 O00206 | P46531 | NOTCH1 [MIM: 190198] | Neurogenic locus notch homolog protein 1 | C6KTB7 | Immune response |
 O00206 | P20749 | BCL3 [MIM: 109560] | B-cell lymphoma 3 protein | C6KTB7 | Regulation of apoptotic process; regulation of interferon-gamma production; T-helper 1 type immune response; positive regulation of interferon-gamma production |
 O00206 | P42771 | CDKN2A [MIM: 600160] | Cyclin-dependent kinase inhibitor 2A | C6KTB7 | Apoptotic process; |
 O00206 | Q8NI38 | NFKBID [MIM: 618887] | NF-kappa-B inhibitor delta | C6KTB7 | Inflammatory response; innate immune response; |
 O00206 | P19838 | NFKB1 [MIM: 164011] | Nuclear factor NF-kappa-B p105 subunit | C6KTB7 | Apoptotic process; inflammatory response; innate immune response; regulation of transcription by RNA polymerase II |
 O00206 | Q8NDB2 | BANK1 [MIM: 610292] | B-cell scaffold protein with ankyrin repeats | C6KTB7 | B cell activation; positive regulation of interleukin-6 production |
 O00206 | Q15653 | NFKBIB [MIM: 604495] | NF-kappa-B inhibitor beta | C6KTB7 | Signal transduction |
B. Shortest paths linking O00206 and C6KTD2 within the host–pathogen unified functional network | |||||
 O00206 | Q13114 | TRAF3 [MIM: 601896] | TNF receptor-associated factor 3 | C6KTD2 | Apoptotic process; innate immune response; toll-like receptor signalling pathway; regulation of interferon-beta production; positive regulation of JNK cascade; |
 O00206 | Q86WT6 | TRIM69 [MIM: 616017] | E3 ubiquitin-protein ligase TRIM69 | C6KTD2 | Apoptotic process |
 O00206 | Q12933 | TRAF2 [MIM: 601895] | TNF receptor-associated factor 2 | C6KTD2 | Positive regulation of JNK cascade; apoptotic process; |
 O00206 | Q9UPN9 | TRIM33 [MIM: 605769] | E3 ubiquitin-protein ligase TRIM33 | C6KTD2 | Negative regulation of transcription by RNA polymerase II; |
 O00206 | P55895 | RAG2 [MIM: 179616] | V(D)J recombination-activating protein 2 | C6KTD2 | B cell homeostatic proliferation; |
 O00206 | O75626 | PRDM1 [MIM: 603423] | PR domain zinc finger protein 1 | C6KTD2 | Adaptive immune response; innate immune response; negative regulation of transcription by RNA polymerase II; |
 O00206 | Q96CA5 | BIRC7 [MIM: 605737] | Baculoviral IAP repeat-containing protein 7 | C6KTD2 | Apoptotic process |
 O00206 | Q8NHM5 | KDM2B [MIM: 609078] | Lysine-specific demethylase 2B | C6KTD2 | Negative regulation of transcription by RNA polymerase II; apoptotic process; |
 O00206 | Q9BUZ4 | TRAF4 [MIM: 602464] | TNF receptor-associated factor 4 | C6KTD2 | Apoptotic process; regulation of I-kappaB kinase/NF-kappaB signalling; |
 O00206 | Q96P53 | WDFY2 [MIM: 610418] | WD repeat and FYVE domain-containing protein 2 | C6KTD2 | Positive regulation of protein phosphorylation |
 O00206 | P15918 | RAG1 [MIM: 179615] | V(D)J recombination-activating protein 1 | C6KTD2 | adaptive immune response; immune response; |
 O00206 | P19474 | TRIM21 [MIM: 109092] | E3 ubiquitin-protein ligase TRIM21 | C6KTD2 | Innate immune response; response to interferon-gamma |
 O00206 | Q9Y4K3 | TRAF6 [MIM: 602355] | TNF receptor-associated factor 6 | C6KTD2 | Activation of MAPK activity; positive regulation of JNK cascade; apoptotic process; toll-like receptor signalling pathway; regulation of transcription by RNA polymerase II |
 O00206 | Q6PCT2 | FBXL19 [MIM: 609085] | F-box/LRR-repeat protein 19 | C6KTD2 | Post-translational protein modification |
 O00206 | Q14258 | TRIM25 [MIM: 600453] | E3 ubiquitin/ISG15 ligase TRIM25 | C6KTD2 | Innate immune response; |
 O00206 | Q9UNE7 | STUB1 [MIM: 607207] | E3 ubiquitin-protein ligase CHIP | C6KTD2 | Protein ubiquitination |
 O00206 | Q15075 | EEA1 [MIM: 605070] | Early endosome antigen 1 | C6KTD2 | Endocytosis |
 O00206 | Q8IWB7 | WDFY1 [MIM: 618080] | WD repeat and FYVE domain-containing protein 1 | C6KTD2 | Positive regulation of toll-like receptor 3 and 4 signalling pathway |
 O00206 | Q09472 | EP300 [MIM: 602700] | Histone acetyltransferase p300 | C6KTD2 | Apoptotic process; positive regulation of NIK/NF-kappaB signalling |
 O00206 | Q8IYM9 | TRIM22 [MIM: 606559] | E3 ubiquitin-protein ligase TRIM22 | C6KTD2 | positive regulation of I-kappaB kinase/NF-kappaB signalling |
 O00206 | Q9Y2K7 | KDM2A [MIM: 605657] | Lysine-specific demethylase 2A | C6KTD2 | Histone H3-K36 demethylation |
 O00206 | Q9NQV6 | PRDM10 [MIM: 618319] | PR domain zinc finger protein 10 | C6KTD2 | Positive regulation of transcription by RNA polymerase II |
 O00206 | Q92793 | CREBBP [MIM: 600140] | CREB-binding protein | C6KTD2 | Positive regulation of transcription by RNA polymerase II; apoptotic process |
 O00206 | Q6UWE0 | LRSAM1 [MIM: 610933] | E3 ubiquitin-protein ligase LRSAM1 | C6KTD2 | Ubiquitin-dependent endocytosis; |
 O00206 | Q8WVD3 | RNF138 [MIM: 616319] | E3 ubiquitin-protein ligase RNF138 | C6KTD2 | Protein ubiquitination |
 O00206 | Q8TCQ1 | MARCHF1 [MIM: 613331] | E3 ubiquitin-protein ligase MARCHF1 | C6KTD2 | Immune response |
 O00206 | Q6Q0C0 | TRAF7 [MIM: 606692] | E3 ubiquitin-protein ligase TRAF7 | C6KTD2 | Apoptotic process; positive regulation of MAPK cascade |
 O00206 | O00463 | TRAF5 [MIM: 602356] | TNF receptor-associated factor 5 | C6KTD2 | Apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signalling; positive regulation of JNK cascade; |
 O00206 | Q13233 | MAP3K1 [MIM: 600982] | Mitogen-activated protein kinase kinase kinase 1 | C6KTD2 | Activation of protein kinase activity |
 O00206 | P98170 | XIAP [MIM: 300079] | E3 ubiquitin-protein ligase XIAP | C6KTD2 | Regulation of innate immune response; regulation of inflammatory response; apoptic process |
 O00206 | Q6ZMZ0 | RNF19B [MIM: 610872] | E3 ubiquitin-protein ligase RNF19B | C6KTD2 | Adaptive immune response |
 O00206 | O14964 | HGS [MIM: 604375] | Hepatocyte growth factor-regulated tyrosine kinase substrate | C6KTD2 | Regulation of MAP kinase activity; positive regulation of gene expression |
 O00206 | Q9NWF9 | RNF216 [MIM:] | E3 ubiquitin-protein ligase RNF216 | C6KTD2 | Apoptotic process |