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Table 1 Factors affecting inter-study comparability of human field studies of plasma EVs in malaria

From: Extracellular vesicles in malaria: an agglomeration of two decades of research

Plasmodium species Sample size EV isolation method EV analysis technique Plasma EVs analysed References
P. vivax 37 Medium speed centrifugation (14,000×g) FC LEVs, MEVs, REVs, PEVs, EEVs [17]
P. falciparum 250 Medium speed centrifugation (1500×g)a FC EEVs [32]
P. falciparum 146 Medium speed centrifugation (13,000×g)a FC LEVs, MEVs, REVs, PEVs, EEVs [33]
P. falciparum 128 High speed ultracentrifugation (100,000×g) FC REVs, PEVs, EEVs [34]
P. falciparum 128 High speed ultracentrifugation (100,000×g)a FC REVs, PEVs, EEVs [35]
P. falciparum, P. vivax, P. malariae 36 Medium speed centrifugation (13,000×g) FC REVs [36]
P. falciparum 434 Medium speed centrifugation (15,000×g) for mEVs;
High speed ultracentrifugation (100,000×g) for sEVs
FC
NTA
TEM
WBA
Total plasma EVs [42]
  1. FC flow cytometry, NTA Nanoparticle Tracking Analysis, TEM Transmission Electron Microscopy, WBA Western Blot Analysis; g- relative centrifugal forcea Indicates that the centrifugation speed was not clearly stated in the journal article