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Fig. 1 | Malaria Journal

Fig. 1

From: Longitudinal analysis of FcRL5 expression and clonal relationships among classical and atypical memory B cells following malaria

Fig. 1

Summary of the current knowledge on the origin of and connections between classical and atypical MBCs. A Potential differentiation pathways of classical memory B cells (cMBCs) and atypical memory B cells (atMBCs). Upon antigen exposure, naïve B cells become activated and can differentiate into antibody-secreting cells (not shown) or classical MBCs. Atypical MBCs are detected after primary P. falciparum infection and may thus be derived from naïve B cells, either directly or through an intermediate cell type. It is not known whether classical MBCs can also differentiate into atypical MBCs after antigen exposure, and whether there is a difference in differentiation pathways between IgM+ and IgG+ atypical MBCs. Classical MBCs are defined by the expression of surface markers CD21 and CD27, while the majority of classical MBCs lack FcRL5. Atypical MBCs are defined by the absence of CD21 and CD27. Most atypical MBCs express FcRL5 and other markers described in the main text. B FcRL5 and FcRL5+ classical and atypical MBCs showed differences in their ability to differentiate into antibody-secreting cells when stimulated in vitro with soluble antigen and other stimuli. The relative number of antibody-secreting cells after stimulation is represented by the number of immunoglobulin molecules. These results suggest that FcRL5+ classical and atypical MBCs may be developmentally related

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