Fig. 2
Changes in FcRL5 expression in different B cell subsets after malaria. A Schematic overview of the medical history of the two 5-year old children included in this study. The three time points of sampling are indicated (circles with 0, 3, and 6 months). Both children had a positive blood smear without malaria in the 1.5 years prior to the first time point and an episode of uncomplicated malaria between the second and the third time point. B Expression of FcRL5 on the cell surface of naïve B cells (NBCs; CD21+CD27−), classical memory B cells (cMBCs, CD21+CD27+), activated memory B cells (actMBCs; CD21−CD27+), and atypical memory B cells (atMBCs; CD21−CD27−) after malaria. C The percentage of cells that are CD19hiFcRL5+ among unswitched (IgM+) and class-switched (IgG+) classical MBCs, activated MBCs, and atypical MBCs. D Changes in the percentage of CD19hiFcRL5+ cells among IgM+ and IgG+ classical MBCs, activated MBCs, and atypical MBCs during the malaria-free period (time points at 0 and 3 months) and the period with a malaria episode (3 to 6 months). Data points with a black outline show results for child with cohort ID 3289, while data points without an outline depict results for child with cohort ID 3421