Fig. 8

The origin of IgM⁺ atypical MBCs revealed by comparison of BCR repertoires between B cell subsets. A Similarity in B cell repertoires between IgM⁺ atypical MBCs at the time point indicated on the x-axis and other IgM⁺ B cell subsets as indicated above the graph at each of the three time points, resulting in three data points per child. Similarity between repertoires was calculated as the Morisita-Horn (MH) index, which ranges between a score of 0 (completely dissimilar) and 1 (identical). The non-parametric paired Wilcoxon signed-rank test was used to test for statically significant differences in MH-index between pairs of B cell subsets for both children combined. B Changes in BCR repertoire similarities within IgM⁺ B cell subsets. The graphs show the MH-index between cells present at the first time point and cells present at each of the three time points. The average difference in MH-index for cells at the second and third time point is indicated. C Similarity in B cell repertoires between IgG⁺ atypical MBCs at the time point indicated on the x-axis and other IgG⁺ B cell subsets as indicated above the graph at each of the three time points, resulting in three data points per child, as in panel A. D Changes in BCR repertoire similarities within IgG⁺ B cell subsets, as in panel B. Data for child with cohort ID 3289 is shown in orange, while data for child with cohort ID 3421 is shown in blue